ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ β Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGM1: ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π»
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ Π½Π°: ΠΡΠ΅ΡΠΎΡΠ·Π½ΠΎΠΌ ΡΠΈΠΌΠΏΠΎΠ·ΠΈΡΠΌΠ΅ «ΠΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°. ΠΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΡ», ΠΠΎΡΠΊΠ²Π° 1985 — ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΠΈΡΡΠΎΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ» ΠΠΎΡΠΊΠ²Π°, 2004; ΠΡΠ΅ΡΠΎΡΠ·Π½ΡΠΉ ΡΠΈΠΌΠΏΠΎΠ·ΠΈΡΠΌ ΠΏΠΎ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΠ»ΠΌΠ°-ΠΡΠ°, 1987; ΠΡΠ΅ΡΠΎΡΠ·Π½ΠΎΠΉ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ», ΠΠ΅Π½ΠΈΠ½Π³ΡΠ°Π΄ 1987; ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- I. ΠΠΠΠΠΠΠΠ
- II. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- ΠΠ»Π°Π²Π° 1. ΠΠ»ΠΈΠΊΠΎΠ»ΠΈΠΏΠΈΠ΄Ρ ΠΈ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ ΠΊΠ°ΠΊ ΠΌΠ°ΡΠΊΠ΅ΡΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ ΠΠΈΡΠ‘Π
- ΠΠ»Π°Π²Π° 2. Π ΠΎΠ»Ρ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ² Π² ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡΡ
- 2. 1. ΠΠ»ΠΈΠΊΠΎΡΠΈΠ½Π°ΠΏΡ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 2. 2. ΠΠ»ΠΈΠΊΠΎΡΠΈΠ½Π°ΠΏΡ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 2. 3. ΠΠ»ΠΈΠΊΠΎΡΠΈΠ½Π°ΠΏΡ ΡΡΠ΅ΡΡΠ΅Π³ΠΎ ΡΠΈΠΏΠ°
- 2. 1. ΠΠ»ΠΈΠΊΠΎΡΠΈΠ½Π°ΠΏΡ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 3. 1. ΠΠΏΡΡ ΠΎΠ»Π΅Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Ρ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅
- 3. 2. ΠΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΎΠ²
- 3. 3. ΠΠ°ΡΠΎΠ³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ
- 3. 4. ΠΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ
- III. ΠΠΠ’ΠΠ ΠΠΠΠ« Π ΠΠΠ’ΠΠΠ«
- 4. 1. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ
- 4. 2. Π‘ΡΠ΅Π΄Ρ ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠ²Ρ
- 4. 2. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Ρ ΠΈ ΠΌΠΎΠ½ΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π½ΠΈΠΌ
- 4. 2. 2. 1. ΠΠΈΡΠ‘Π-1 ΠΈ Π΄ΡΡΠ³ΠΈΠ΅ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ
- 4. 2. 2. 2. ΠΡΠΈΡΡΠΊΠ° ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π»
- 4. 2. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Ρ ΠΈ ΠΌΠΎΠ½ΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π½ΠΈΠΌ
- 4. 3. 1. ΠΠ΅ΠΏΡΡΠΌΠΎΠΉ ΠΠ€Π
- 4. 3. 2. ΠΡΠΎΡΠ΅Π΄ΡΡΠ° ΠΏΡΡΠΌΠΎΠ³ΠΎ ΠΠ€Π
- 4. 3. 3. ΠΡΠΎΡΠ΅Π΄ΡΡΠ° «ΡΡΠ½Π΄Π²ΠΈΡ» ΠΠ€Π
- 4. 8. 1. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π»ΠΈΠ½ΠΈΠΈ
- 4. 8. 2. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ
- 4. 8. 3. Π‘Π±ΠΎΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ²
- 4. 8. 4. ΠΠΊΡΠ°ΡΠΊΠ° Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ²
- 5. 1. Π’Π΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΌΡΡΠ΅ΠΉ
- 5. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ
- 5. 3. Π’Π΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ€Π
- 5. 4. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π»
- 5. 4. 1. ΠΠ·ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ’
- 5. 4. 2. ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΠΠ’
- 5. 4. 3. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΠΠ’ ΠΏΡΠΎΡΠΈΠ² FucGM
- 5. 5. Π₯ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ
- 6. 1. ΠΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΠΈΡΠ‘Π-1 Π² ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
- 6. 1. 1. ΠΠ½Π°Π»ΠΈΠ· Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
- 6. 1. 2. ΠΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΠΈ Π΄ΡΡΠ³ΠΈΡ ΠΠΈΡΠ‘Π-1 ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ
- 6. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΈΡΠ‘Π1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
- 6. 2. 1. Π Π°Π΄ΠΈΠΎΠΈΠΌΠΌΡΠ½ΠΎΡ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΠΈΡΠ‘Π-1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ
- 6. 2. 2. Π€ΡΠΊΠΎΠ·ΠΈΠ»ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ
- 6. 3. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΠ€Π Ρ ΠΠΠ’ ΠΏΡΠΎΡΠΈΠ² Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π
- 6. 3. 1. ΠΠ½ΡΠΈΠ»ΠΈΠΏΠΈΠ΄Π½ΡΠ΅ ΠΈ Π°Π½ΡΠΈ-ΠΠΈΡΠ‘Π-1 Π°Π½ΡΠΈΡΠ΅Π»Π° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
- V. ΠΠΠ‘Π£ΠΠΠΠΠΠ
- VI. ΠΠ«ΠΠΠΠ«
ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ β Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGM1: ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΡΠ΅ΠΌΡ
.
Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΠΏΡΠΈΡΡΠ°Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ, Π·Π°Π½ΠΈΠΌΠ°ΡΡΠΈΡ ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΎΠΉ ΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ², ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°Π΅Ρ ΠΎΠ±ΡΠΈΡΠ½ΡΠΉ ΠΊΠ»Π°ΡΡ Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ — Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ². ΠΡΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½ΡΠ΅Ρ ΡΠΎ, ΡΡΠΎ ΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ ΡΠΎΡΡΠΎΡΡ ΠΈΠ· Π΄Π²ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² — ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈ Π½Π΅ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ.
ΠΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΡΡΠΈΠΌ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌ Π²ΡΠ·Π²Π°Π½ ΡΠ΅ΠΌ, ΡΡΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΈΡ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ² Π² ΡΠΊΠ°Π½ΡΡ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΈ ΡΠ΅Π»ΠΎΠ·Π΅ΠΊΠ° ΠΏΡΠΈ ΡΡΠ΄Π΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π² Ρ. Ρ. ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ (16), ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ (103). Π£ΡΠΏΠ΅ΡΠ½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ ΠΏΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΡΡΠ΅ΠΌ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠ½ΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ (11,12,13,36) ΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ (12 6,127,181) Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°ΠΌ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ (26) ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ.
ΠΠ°ΡΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΏΡΠΈΠ²Π»Π΅ΠΊ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡΡΠ³Π°Ρ Ρ ΠΌΠ°Π»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ — Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ Fuc GM1, ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠΉ Π² ΡΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (118).
ΠΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΠ»ΠΈ, ΡΡΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΡΠΎΠΌΡ Π°Π½ΡΠΈΠ³Π΅Π½Ρ ΠΏΠΎΠΌΠΎΠΆΠ΅Ρ ΠΈΠ·ΡΡΠΈΡΡ Π΅Π³ΠΎ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈ Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGMl ΠΈ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π½Π΅ΠΌΡ Π² ΡΠΊΠ°Π½ΡΡ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡΡ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ.
Π¦Π΅Π»Ρ ΠΈ Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ.
Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΊΠΌΠΌΡΠΊΠΎΡ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΡ ΠΎΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ ΠΏΡΡΠ΅ΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ Π1ΡΠ‘Π1, ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ² ΡΡΠΈΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ ΠΈ ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΠ΅ΠΌΡΡ ΠΈΠΌΠΈ Π°Π½ΡΠΈΡΠ΅Π». Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π±ΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ:
1.ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΡ ΠΠΠ’ ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ.
ΠΠΈΡΠΠ£Π.
2. Π¦ΠΈΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ² ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» .
3. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌ Π΄Π»Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠ΅ΠΊΡΠΈΠΈ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1 Π² ΡΠΊΠ°Π½ΡΡ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡΡ . ΠΡΠ΅Π½ΠΊΠ° ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΈΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ .
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΡΠ°Π±ΠΎΡΡ.
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΠΠ’ ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ ΠΠΈΡΠ‘Π1. Π‘ ΠΈΡ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΠΈΡΠ‘Π1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ.
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π» ΠΏΡΠΎΡΠΈΠ² Π’ΠΈΡΠ‘Π1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ .
Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΠΠ€Π ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΠ° Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΠ’ ΠΊ ΠΠΈΡΠ‘Π1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ.
Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΠ½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΠ€Π Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ² ΠΈ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΠΈΡΠ‘Π!
Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΌΠ΅ΡΠΎΠ΄ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΠΈΡΠ‘Π1. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΠΈΡΠ‘Π1 Π² ΡΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.
ΠΠ·ΡΡΠ΅Π½ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΠ½ΡΠΉ ΡΠΎΡΡΠ°Π² ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠ²ΡΠ·Ρ ΡΠ΅Π³ΡΠ΅Π³Π°ΡΠΈΠΈ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌ Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π».
Π’Π΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
ΠΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π΅Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠΉ ΡΠ°ΠΊΡ Π½Π°Π»ΠΈΡΠΈΡ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. Π’Π΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠΎΡΡΠΎΠΈΡ Π² ΡΠΎΠΌ, ΡΡΠΎ Π΄ΠΎ ΡΠΈΡ ΠΏΠΎΡ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ.
ΠΠΎΠ²ΡΠΌ ΡΠ°ΠΊΡΠΎΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π°Π½ΡΠΈΠ³Π΅Π½Π°ΠΌ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΌ ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΡΡ ΡΡΠΊΠΎΠ·Ρ, Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ 8 5 ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΠ²ΡΠ·Ρ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Ρ Π°Π½ΠΎΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΡΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, ΡΡΠΎ Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ (Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠΉ Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ) ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠΊΠΎΠ·ΠΈΠ»ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·.
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠΈ ΠΠΠ’ ΠΏΡΠΎΡΠΈΠ² ΠΠΈΡΠ‘Π1, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ ΡΠ»ΡΠΆΠΈΡΡ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠΌ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡΠΌΠΎΠ· Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ Π΄Π»Ρ ΠΈΡ ΠΏΠ°ΡΠΏΠΎΡΡΠΈΠ·Π°ΡΠΈΠΈ.
ΠΠΏΡΠΎΠ±Π°ΡΠΈΡ ΡΠ°Π±ΠΎΡΡ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ Π½Π°: ΠΡΠ΅ΡΠΎΡΠ·Π½ΠΎΠΌ ΡΠΈΠΌΠΏΠΎΠ·ΠΈΡΠΌΠ΅ «ΠΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°. ΠΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΡ», ΠΠΎΡΠΊΠ²Π° 1985 — ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΠΈΡΡΠΎΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ» ΠΠΎΡΠΊΠ²Π°, 2004; ΠΡΠ΅ΡΠΎΡΠ·Π½ΡΠΉ ΡΠΈΠΌΠΏΠΎΠ·ΠΈΡΠΌ ΠΏΠΎ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΠ»ΠΌΠ°-ΠΡΠ°, 1987; ΠΡΠ΅ΡΠΎΡΠ·Π½ΠΎΠΉ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ», ΠΠ΅Π½ΠΈΠ½Π³ΡΠ°Π΄ 1987; ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΠΈΡΡΠΎΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ», ΠΠΎΡΠΊΠ²Π°, 1988; XVIIIth Meeting of ISOBM, Abstr., Moskow, 1990;
Π Π°ΡΡΠΈΡΠ΅Π½Π½ΠΎΠΌ Π·Π°ΡΠ΅Π΄Π°Π½ΠΈΠΈ Π£ΡΠ΅Π½ΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΠ° ΠΠΠ ΠΠ§ Π ΠΠΠ, 2004 Π³.
ΠΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ.
ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Ρ Π² 12 ΠΏΠ΅ΡΠ°ΡΠ½ΡΡ ΡΠ°Π±ΠΎΡΠ°Ρ .
Π‘ΡΡΡΠΊΡΡΡΠ° Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ.
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· ΡΠ»Π΅Π΄ΡΡΡΠΈΡ ΡΠ°Π·Π΄Π΅Π»ΠΎΠ²: Π²Π²Π΅Π΄Π΅Π½ΠΈΡ, ΠΎΠ±Π·ΠΎΡΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ (3 Π³Π»Π°Π²Ρ), ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ (1 Π³Π»Π°Π²Π°), ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ (2 Π³Π»Π°Π²Ρ), ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², Π²ΡΠ²ΠΎΠ΄Ρ ΠΈ ΡΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ. ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ Π½Π°ΠΏΠΈΡΠ°Π½Π° Π½Π° ΡΡΡΡΠΊΠΎΠΌ ΡΠ·ΡΠΊΠ΅, Π½Π° 156 ΡΡΡΠ°Π½ΠΈΡΠ°Ρ ΠΌΠ°ΡΠΈΠ½ΠΎΠΏΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΊΡΡΠ° ΠΈ ΠΈΠ»Π»ΡΡΡΡΠΈΡΠΎΠ²Π°Π½Π° 31 ΡΠΈΡΡΠ½ΠΊΠΎΠΌ ΠΈ 5 ΡΠ°Π±Π»ΠΈΡΠ°ΠΌΠΈ. Π£ΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 190 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², ΠΈΠ· Π½ΠΈΡ 10 ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΈ 180 ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΡ .
II. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«.
ΠΡΠ²ΠΎΠ΄Ρ.
1. Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΠ½ΠΎΠΉ Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΠ·Π΄Π°Π½Ρ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΡ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΏΡΠΎΡΠΈΠ² Π³Π»ΠΈΠΊΠΎΠ»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° — Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1.
2. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΊΠ°ΡΠΈΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΈΠ΅Π»ΠΎΠΌΡ Π»ΠΈΠ½ΠΈΠΈ Π ΠΠ₯Π±Π. ΠΠ΄8.653 ΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠ΅ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΠΈ ΠΏΠ°ΡΠΏΠΎΡΡΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΠ½ΡΠ΅ ΠΊΠ»ΠΎΠ½Ρ.
3. ΠΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ°Π²ΡΠΎΡΠ°Π΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠΎΠ½ΠΊΠΎΡΠ»ΠΎΠΉΠ½ΡΡ ΠΏΠ»Π°ΡΡΠΈΠ½Π°Ρ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π», ΡΠ΅Π°Π³ΠΈΡΡΡΡΠΈΡ Ρ ΠΠΈΡΠ‘Π1 ΠΈ Π½Π΅ Π΄Π°ΡΡΠΈΡ ΠΏΠ΅ΡΠ΅ΠΊΡΠ΅ΡΡΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Ρ ΡΠΈΡΠΎΠΊΠΎΠΉ ΠΏΠ°Π½Π΅Π»ΡΡ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ², Π² Ρ. Ρ. Ρ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠΌ Π‘Π1 — ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠΌ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ . ΠΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ ΠΏΠΎ Π°ΡΡΠΈΠ½Π½ΠΎΡΡΠΈ ΠΈ ΠΊΠ»Π°ΡΡΠΎΠ²ΠΎΠΉ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ½ΠΎΡΡΠΈ (1Π΄Π‘Π).
4. Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΎΠ½ΠΊΠΎΡΠ»ΠΎΠΉΠ½ΠΎΠΉ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ°Π²ΡΠΎΡΠ°Π΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΠΈΡΠ‘Π1 Π² ΡΠΊΡΡΡΠ°ΠΊΡΠ°Ρ ΡΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ Π²ΠΎ Π²ΡΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ ΡΠ»ΡΡΠ°ΡΡ ΠΈ Π΅Π³ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π² ΡΠΊΠ°Π½ΡΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ Π»Π΅Π³ΠΊΠΈΡ ΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΈΡ .
5. Π ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ ΠΏΡΠΈΡΡΡΡΡΠ²ΡΠ΅Ρ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ ΠΠΈΡΠ‘Π1.
6. ΠΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠ΅ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ ΠΊΡΠΈΠΎΡΡΠ°ΡΠ½ΡΡ ΡΡΠ΅Π·ΠΎΠ² ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1 Π² 85% ΠΈΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠ°Π½Π½ΡΠΉ Π°Π½ΡΠΈΠ³Π΅Π½ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ Π² ΡΠΊΠ°Π½ΡΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ Π»Π΅Π³ΠΊΠΈΡ , Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ΅ Π»Π΅Π³ΠΊΠΈΡ ΠΈ ΠΎΠΏΡΡ ΠΎΠ»ΡΡ Π΄ΡΡΠ³ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ.
7. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1 ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ.
8. ΠΡΡΠΎΠΊΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΠΊΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΏΡΠΎΡΠΈΠ² Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° ΠΠΈΡΠ‘Π1 ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ².
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