Π”ΠΈΠΏΠ»ΠΎΠΌΡ‹, курсовыС, Ρ€Π΅Ρ„Π΅Ρ€Π°Ρ‚Ρ‹, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Ρ‹Π΅...
Брочная ΠΏΠΎΠΌΠΎΡ‰ΡŒ Π² ΡƒΡ‡Ρ‘Π±Π΅

ЭкспрСссия ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… β€” Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGM1: иммуноморфологичСскоС ΠΈ иммунохимичСскоС исслСдованиС с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π»

Π”ΠΈΡΡΠ΅Ρ€Ρ‚Π°Ρ†ΠΈΡΠŸΠΎΠΌΠΎΡ‰ΡŒ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈΠ£Π·Π½Π°Ρ‚ΡŒ ΡΡ‚ΠΎΠΈΠΌΠΎΡΡ‚ΡŒΠΌΠΎΠ΅ΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹

ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ диссСртации Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ‹ Π½Π°: Π’ΡΠ΅ΡΠΎΡŽΠ·Π½ΠΎΠΌ симпозиумС «ΠšΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ основы ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°. Π“ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌΡ‹», Москва 1985 — ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы соврСмСнной гистопатологии» Москва, 2004; Π’ΡΠ΅ΡΠΎΡŽΠ·Π½Ρ‹ΠΉ симпозиум ΠΏΠΎ Π±ΠΈΠΎΡ…ΠΈΠΌΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², Алма-Ата, 1987; Π’ΡΠ΅ΡΠΎΡŽΠ·Π½ΠΎΠΉ Π½Π°ΡƒΡ‡Π½ΠΎΠΉ ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы Π±ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ», Π›Π΅Π½ΠΈΠ½Π³Ρ€Π°Π΄ 1987; ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы соврСмСнной… Π§ΠΈΡ‚Π°Ρ‚ΡŒ Π΅Ρ‰Ρ‘ >

Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅

  • I. Π’Π’Π•Π”Π•ΠΠ˜Π•
  • II. ΠžΠ‘Π—ΠžΠ  Π›Π˜Π’Π•Π ΠΠ’Π£Π Π«
  • Π“Π»Π°Π²Π° 1. Π“Π»ΠΈΠΊΠΎΠ»ΠΈΠΏΠΈΠ΄Ρ‹ ΠΈ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡŠΡŽΠ³Π°Ρ‚Ρ‹ ΠΊΠ°ΠΊ ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Ρ‹ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π“Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ Π“ΠΈΡΠ‘Πœ
  • Π“Π»Π°Π²Π° 2. Роль Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ² Π² ΠΌΠ΅ΠΆΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… взаимодСйствиях
    • 2. 1. Гликосинапс ΠΏΠ΅Ρ€Π²ΠΎΠ³ΠΎ Ρ‚ΠΈΠΏΠ°
      • 2. 2. Гликосинапс Π²Ρ‚ΠΎΡ€ΠΎΠ³ΠΎ Ρ‚ΠΈΠΏΠ°
      • 2. 3. Гликосинапс Ρ‚Ρ€Π΅Ρ‚ΡŒΠ΅Π³ΠΎ Ρ‚ΠΈΠΏΠ°
  • Π“Π»Π°Π²Π° 3. ΠœΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° для диагностики ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 3. 1. ΠžΠΏΡƒΡ…ΠΎΠ»Π΅Π°ΡΡΠΎΡ†ΠΈΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Ρ‹ Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅
    • 3. 2. Локализация ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈ ΠΌΠ΅Ρ‚астазов
    • 3. 3. ΠŸΠ°Ρ‚ΠΎΠ³ΠΈΡΡ‚ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠ°Ρ диагностика ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • 3. 4. Π˜ΠΌΠΌΡƒΠ½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΡ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ
    • III. ΠœΠΠ’Π•Π Π˜ΠΠ›Π« И ΠœΠ•Π’ΠžΠ”Π«
  • Π“Π»Π°Π²Π° 4.
    • 4. 1. ΠšΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ
    • 4. 2. Π‘Ρ€Π΅Π΄Ρ‹ ΠΈ Ρ€Π΅Π°ΠΊΡ‚ΠΈΠ²Ρ‹
      • 4. 2. 2. АнтигСны ΠΈ ΠΌΠΎΠ½ΠΎΡΠΏΠ΅Ρ†ΠΈΡ„ичСскиС Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΊ Π½ΠΈΠΌ
        • 4. 2. 2. 1. Π“ΠΈΡΠ‘Πœ-1 ΠΈ Π΄Ρ€ΡƒΠ³ΠΈΠ΅ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ‹
        • 4. 2. 2. 2. ΠžΡ‡ΠΈΡΡ‚ΠΊΠ° ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π»
    • 4. 3. ΠŸΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° ΠΈΠΌΠΌΡƒΠ½ΠΎΡ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° (ИЀА)
      • 4. 3. 1. НСпрямой ИЀА
      • 4. 3. 2. ΠŸΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° прямого ИЀА
      • 4. 3. 3. ΠŸΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π° «ΡΡΠ½Π΄Π²ΠΈΡ‡» ИЀА
    • 4. 4. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ константы связывания МАВ
    • 4. 5. Π˜Π·ΠΎΡ‚ΠΈΠΏΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ МАВ
    • 4. 6. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ
    • 4. 7. РадиоиммунологичСскоС выявлСниС Π³Π»ΠΈΠΊΠΎΠ»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° Π½Π° Ρ‚онкослойных пластинах
    • 4. 8. Π₯ромосомный Π°Π½Π°Π»ΠΈΠ· Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ ΠΏΡ€ΠΎΡ‚ΠΈΠ² FucGM
      • 4. 8. 1. Π˜ΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Π½Ρ‹Π΅ ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π»ΠΈΠ½ΠΈΠΈ
      • 4. 8. 2. ΠšΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ
      • 4. 8. 3. Π‘Π±ΠΎΡ€ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ ΠΈ ΠΏΡ€ΠΈΠ³ΠΎΡ‚ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ хромосомных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ²
      • 4. 8. 4. ΠžΠΊΡ€Π°ΡΠΊΠ° хромосомных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ²
    • 4. 9. Π˜ΠΌΠΌΡƒΠ½ΠΎΠΌΠΎΡ€Ρ„ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΠ΅ исслСдования
    • 4. 10. БтатистичСская ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ²
    • IV. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ собствСнных исслСдований
  • Π“Π»Π°Π²Π° 5. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ МАВ ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGMl
    • 5. 1. ВСстированиС ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π²Π΅Ρ‚Π° ΠΌΡ‹ΡˆΠ΅ΠΉ
    • 5. 2. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ
    • 5. 3. ВСстированиС ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ИЀА
    • 5. 4. Π₯арактСристика ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π»
      • 5. 4. 1. Π˜Π·ΠΎΡ‚ΠΈΠΏΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ МАВ
      • 5. 4. 2. Π˜Π·ΠΌΠ΅Ρ€Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ МАВ
      • 5. 4. 3. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ спСцифичности МАВ ΠΏΡ€ΠΎΡ‚ΠΈΠ² FucGM
    • 5. 5. Π₯ромосомный Π°Π½Π°Π»ΠΈΠ· Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ
  • Π“Π»Π°Π²Π°. Π±. ВыявлСниС Π“ΠΈΡΠ‘Πœ-1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ Ρ‚канях онкологичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…
    • 6. 1. ВыявлСниС Π“ΠΈΡΠ‘Πœ-1 Π² ΠΎΠΏΡƒΡ…олях Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
      • 6. 1. 1. Анализ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π½ΠΎΠ³ΠΎ состава ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
      • 6. 1. 2. Π˜ΠΌΠΌΡƒΠ½ΠΎΡ„Π»ΡƒΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠ΅ исслСдованиС ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈ Π΄Ρ€ΡƒΠ³ΠΈΡ… Π“ΠΈΡΠ‘Πœ-1 содСрТащих Ρ‚ΠΊΠ°Π½Π΅ΠΉ
    • 6. 2. ИсслСдованиС Π“ΠΈΡΠ‘Πœ1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
      • 6. 2. 1. РадиоиммунохроматографичСский Π°Π½Π°Π»ΠΈΠ· Π•ΠΈΡΠ‘Πœ-1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ…
      • 6. 2. 2. ЀукозилтрансфСразная Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ сывороток Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ…
    • 6. 3. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ ИЀА с ΠœΠΠ’ ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π“ΠΈΡΠ‘Πœ
      • 6. 3. 1. АнтилипидныС ΠΈ Π°Π½Ρ‚ΠΈ-Π“ΠΈΡΠ‘Πœ-1 Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
    • V. ΠžΠ‘Π‘Π£Π–Π”Π•ΠΠ˜Π•
    • VI. Π’Π«Π’ΠžΠ”Π«

ЭкспрСссия ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… β€” Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGM1: иммуноморфологичСскоС ΠΈ иммунохимичСскоС исслСдованиС с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» (Ρ€Π΅Ρ„Π΅Ρ€Π°Ρ‚, курсовая, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Π°Ρ)

ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Ρ‚Π΅ΠΌΡ‹

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Π’ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ‹ ΠΏΡ€ΠΈΡΡ‚Π°Π»ΡŒΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ исслСдоватСлСй, Π·Π°Π½ΠΈΠΌΠ°ΡŽΡ‰ΠΈΡ…ΡΡ молСкулярной диагностикой ΠΈ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠ΅ΠΉ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… патологичСских процСссов, ΠΏΡ€ΠΈΠ²Π»Π΅ΠΊΠ°Π΅Ρ‚ ΠΎΠ±ΡˆΠΈΡ€Π½Ρ‹ΠΉ класс химичСских соСдинСний — Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡŒΡŽΠ³Π°Ρ‚ΠΎΠ². Π­Ρ‚ΠΈ соСдинСния ΠΎΠ±ΡŠΠ΅Π΄ΠΈΠ½ΡΠ΅Ρ‚ Ρ‚ΠΎ, Ρ‡Ρ‚ΠΎ ΠΈΡ… ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»Ρ‹ состоят ΠΈΠ· Π΄Π²ΡƒΡ… ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠ² — ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈ Π½Π΅ΡƒΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ.

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΡΡ‚ΠΈΠΌ вСщСствам Π²Ρ‹Π·Π²Π°Π½ Ρ‚Π΅ΠΌ, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΈΡ… ΠΏΡ€ΠΈΡΡƒΡ‚ствиС Π² ΠΊΠ°Ρ‡Π΅ΡΡ‚Π²Π΅ спСцифичСских Π°Π½Ρ‚ΠΈΠ³Π΅Π½ΠΎΠ² Π² Ρ‚канях ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΡ… Тидкостях ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Ρ… ΠΈ Ρ‡Π΅Π»ΠΎΠ·Π΅ΠΊΠ° ΠΏΡ€ΠΈ рядС Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π² Ρ‚. Ρ‡. онкологичСских (16), соматичСских (103). Π£ΡΠΏΠ΅ΡˆΠ½Ρ‹Π΅ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΏΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΡŽ диагностичСских систСм Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ моноспСцифичСских (11,12,13,36) ΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… (12 6,127,181) Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΊ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡŒΡŽΠ³Π°Ρ‚Π°ΠΌ ΠΈ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½ΠΈΡŽ Ρ‚Π°ΠΊΠΈΡ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» Π² ΠΊΠ»ΠΈΠ½ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅ (26) ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΏΠ΅Ρ€ΡΠΏΠ΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ этого направлСния исслСдований.

НашС Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΏΡ€ΠΈΠ²Π»Π΅ΠΊ Π³Π»ΠΈΠΊΠΎΠΊΠΎΠ½ΡŒΡŽΠ³Π°Ρ‚ с ΠΌΠ°Π»ΠΎ исслСдованными свойствами — Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ Fuc GM1, ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½Ρ‹ΠΉ Π² Ρ‚ΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (118).

ΠœΡ‹ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΠ»ΠΈ, Ρ‡Ρ‚ΠΎ созданиС ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΊ ΡΡ‚ΠΎΠΌΡƒ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Ρƒ ΠΏΠΎΠΌΠΎΠΆΠ΅Ρ‚ ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ Π΅Π³ΠΎ свойства ΠΈ Π΄Π°ΡΡ‚ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚ΡŒ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° FucGMl ΠΈ Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΊ Π½Π΅ΠΌΡƒ Π² Ρ‚канях ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΡ… Тидкостях Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ.

ЦСль ΠΈ Π·Π°Π΄Π°Ρ‡ΠΈ исслСдований.

ЦСлью исслСдования являлось кммукохроматографичСсхоС ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΡ…имичСскоС ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ экспрСссии ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… ΠΏΡƒΡ‚Π΅ΠΌ получСния Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ, ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρƒ Π•1сБМ1, ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ свойств этих Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ ΠΈ ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΠ΅ΠΌΡ‹Ρ… ΠΈΠΌΠΈ Π°Π½Ρ‚ΠΈΡ‚Π΅Π». Π’ ΡΠ²ΡΠ·ΠΈ с ΡΡ‚ΠΈΠΌ Π±Ρ‹Π»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ Π·Π°Π΄Π°Ρ‡ΠΈ исслСдования:

1.ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ, ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… МАВ ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρƒ.

Π•ΠΈΡΠžΠ£Π˜.

2. ЦитогСнСтичСская характСристика Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ свойств ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» .

3. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» тСст-систСм для ΠΈΠΌΠΌΡƒΠ½ΠΎΠ΄Π΅Ρ‚Π΅ΠΊΡ†ΠΈΠΈ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π“ΠΈΡΠ‘Πœ1 Π² Ρ‚канях ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈΡ… Тидкостях. ΠžΡ†Π΅Π½ΠΊΠ° пСрспСктивы ΠΈΡ… ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… исслСдованиях.

Научная Π½ΠΎΠ²ΠΈΠ·Π½Π° Ρ€Π°Π±ΠΎΡ‚Ρ‹.

Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ МАВ ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρƒ Π“ΠΈΡΠ‘Πœ1. Π‘ ΠΈΡ… ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ Π“ΠΈΡΠ‘Πœ1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ.

Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π•’исБМ1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ онкологичСских Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ….

Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° ИЀА тСст-систСма для опрСдСлСния ΠΠ’ ΠΊ Π•ΠΈΡΠ‘М1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ.

Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° модСльная систСма ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ ИЀА для выявлСния Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ² ΠΈ, Π² Ρ‡Π°ΡΡ‚ности, Π“ΠΈΡΠ‘Πœ!

Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ ΠΌΠ΅Ρ‚ΠΎΠ΄ иммунофлуорСсцСнтного ΠΎΠΊΡ€Π°ΡˆΠΈΠ²Π°Π½ΠΈΡ Ρ‚ΠΊΠ°Π½Π΅ΠΉ для выявлСния Π“ΠΈΡΠ‘Πœ1. Показана экспрСссия Π“ΠΈΡΠ‘Πœ1 Π² Ρ‚ΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°.

Π˜Π·ΡƒΡ‡Π΅Π½ хромосомный состав ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ. Показана связь сСгрСгации хромосом с ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ активности ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π».

ВСорСтичСская ΠΈ ΠΏΡ€Π°ΠΊΡ‚ичСская Ρ†Π΅Π½Π½ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ исслСдования.

ΠŸΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΈΠ°Π»ΡŒΠ½ΠΎΠ΅ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π΅Ρ‚ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Π½Ρ‹ΠΉ Ρ„Π°ΠΊΡ‚ наличия Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π•ΠΈΡΠ‘Πœ1 Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. ВСорСтичСская Ρ†Π΅Π½Π½ΠΎΡΡ‚ΡŒ этого наблюдСния состоит Π² Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ Π΄ΠΎ ΡΠΈΡ… ΠΏΠΎΡ€ нСизвСстны спСцифичСскиС ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Ρ‹ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ.

Новым Ρ„Π°ΠΊΡ‚ΠΎΠΌ являСтся ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΈΠ΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΊ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π°ΠΌ, содСрТащим Ρ‚Π΅Ρ€ΠΌΠΈΠ½Π°Π»ΡŒΠ½ΡƒΡŽ Ρ„ΡƒΠΊΠΎΠ·Ρƒ, Π² ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ 8 5 обслСдованных онкологичСских ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ². Π­Ρ‚ΠΎ ΡƒΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ Π½Π° ΡΠ²ΡΠ·ΡŒ злокачСствСнной трансформации с Π°Π½ΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌ Ρ„ΡƒΠΊΠΎΠ·ΠΈΠ»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, Ρ‡Ρ‚ΠΎ Π² ΡΠ²ΠΎΡŽ ΠΎΡ‡Π΅Ρ€Π΅Π΄ΡŒ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ обусловлСно ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ активности (Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ связанной с ΠΌΡƒΡ‚ациями) спСцифичСских фукозилтрансфСраз.

ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ Ρ†Π΅Π½Π½ΠΎΡΡ‚ΡŒ Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π·Π°ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ΡΡ Π² ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠΈ МАВ ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π•ΠΈΡΠ‘Πœ1, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΌΠΎΠ³ΡƒΡ‚ ΡΠ»ΡƒΠΆΠΈΡ‚ΡŒ инструмСнтом для создания сСрологичСских ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΠΌΠΎΡ€Ρ„ологичСских диагностикумоз для выявлСния ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π½Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ для ΠΈΡ… ΠΏΠ°ΡΠΏΠΎΡ€Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ.

Апробация Ρ€Π°Π±ΠΎΡ‚Ρ‹.

ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ диссСртации Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ‹ Π½Π°: Π’ΡΠ΅ΡΠΎΡŽΠ·Π½ΠΎΠΌ симпозиумС «ΠšΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ основы ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΈΡ‚Π΅Ρ‚Π°. Π“ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌΡ‹», Москва 1985 — ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы соврСмСнной гистопатологии» Москва, 2004; Π’ΡΠ΅ΡΠΎΡŽΠ·Π½Ρ‹ΠΉ симпозиум ΠΏΠΎ Π±ΠΈΠΎΡ…ΠΈΠΌΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², Алма-Ата, 1987; Π’ΡΠ΅ΡΠΎΡŽΠ·Π½ΠΎΠΉ Π½Π°ΡƒΡ‡Π½ΠΎΠΉ ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы Π±ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ», Π›Π΅Π½ΠΈΠ½Π³Ρ€Π°Π΄ 1987; ΠΊΠΎΠ½Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΈ «ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ вопросы соврСмСнной гистопатологии», Москва, 1988; XVIIIth Meeting of ISOBM, Abstr., Moskow, 1990;

Π Π°ΡΡˆΠΈΡ€Π΅Π½Π½ΠΎΠΌ засСдании Π£Ρ‡Π΅Π½ΠΎΠ³ΠΎ совСта НИИ ΠœΠ§ РАМН, 2004 Π³.

ΠŸΡƒΠ±Π»ΠΈΠΊΠ°Ρ†ΠΈΠΈ.

ΠžΡΠ½ΠΎΠ²Π½Ρ‹Π΅ полоТСния диссСртации ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Ρ‹ Π² 12 ΠΏΠ΅Ρ‡Π°Ρ‚Π½Ρ‹Ρ… Ρ€Π°Π±ΠΎΡ‚Π°Ρ….

Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Π° диссСртации.

ДиссСртация состоит ΠΈΠ· ΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΡ… Ρ€Π°Π·Π΄Π΅Π»ΠΎΠ²: ввСдСния, ΠΎΠ±Π·ΠΎΡ€Π° Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ (3 Π³Π»Π°Π²Ρ‹), ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ (1 Π³Π»Π°Π²Π°), Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ собствСнных исслСдований (2 Π³Π»Π°Π²Ρ‹), обсуТдСниС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ², Π²Ρ‹Π²ΠΎΠ΄Ρ‹ ΠΈ ΡΠΏΠΈΡΠΎΠΊ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹. ДиссСртация написана Π½Π° Ρ€ΡƒΡΡΠΊΠΎΠΌ языкС, Π½Π° 156 страницах машинописного тСкста ΠΈ ΠΈΠ»Π»ΡŽΡΡ‚Ρ€ΠΈΡ€ΠΎΠ²Π°Π½Π° 31 рисунком ΠΈ 5 Ρ‚Π°Π±Π»ΠΈΡ†Π°ΠΌΠΈ. Π£ΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ содСрТит 190 источников, ΠΈΠ· Π½ΠΈΡ… 10 отСчСствСнных ΠΈ 180 иностранных.

II. ΠžΠ‘Π—ΠžΠ  Π›Π˜Π’Π•Π ΠΠ’Π£Π Π«.

Π’Ρ‹Π²ΠΎΠ΄Ρ‹.

1. Π‘ ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌΠ½ΠΎΠΉ Π±ΠΈΠΎΡ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ созданы Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌΡ‹, ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π³Π»ΠΈΠΊΠΎΠ»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° — Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π“ΠΈΡΠ‘Πœ1.

2. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ кариотипирования ΠΊΠ»Π΅Ρ‚ΠΎΠΊ ΠΌΠΈΠ΅Π»ΠΎΠΌΡ‹ Π»ΠΈΠ½ΠΈΠΈ Π Π—Π₯Π±Π—. Ад8.653 ΠΈ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌ Π²ΠΏΠ΅Ρ€Π²Ρ‹Π΅ описаны ΠΌΠ°Ρ€ΠΊΠ΅Ρ€Π½Ρ‹Π΅ хромосомы, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΠ΅ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΈ ΠΏΠ°ΡΠΏΠΎΡ€Ρ‚ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠΌΠ½Ρ‹Π΅ ΠΊΠ»ΠΎΠ½Ρ‹.

3. ΠœΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ Ρ‚Π²Π΅Ρ€Π΄ΠΎΡ„Π°Π·Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡƒΠ½ΠΎΡ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΠ°Π²Ρ‚ΠΎΡ€Π°Π΄ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ Π½Π° Ρ‚онкослойных пластинах продСмонстрирована высокая ΡΠΏΠ΅Ρ†ΠΈΡ„ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π», Ρ€Π΅Π°Π³ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… с Π•ΠΈΡΠ‘М1 ΠΈ Π½Π΅ Π΄Π°ΡŽΡ‰ΠΈΡ… пСрСкрСстной Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ с ΡˆΠΈΡ€ΠΎΠΊΠΎΠΉ панСлью Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ², Π² Ρ‚. Ρ‡. с Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠΌ БМ1 — ΡƒΠ½ΠΈΠ²Π΅Ρ€ΡΠ°Π»ΡŒΠ½Ρ‹ΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠΌ ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Ρ‹ ΠΊΠ»Π΅Ρ‚ΠΎΠΊ ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡ‚Π°ΡŽΡ‰ΠΈΡ…. ΠœΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΎΡ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΠΎΠ²Π°Π½Ρ‹ ΠΏΠΎ Π°Ρ„финности ΠΈ ΠΊΠ»Π°ΡΡΠΎΠ²ΠΎΠΉ принадлСТности (1Π΄Π‘Π—).

4. Π‘ΠΎΡ‡Π΅Ρ‚Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² тонкослойной Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ ΠΈ ΠΈΠΌΠΌΡƒΠ½ΠΎΠ°Π²Ρ‚ΠΎΡ€Π°Π΄ΠΈΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ присутствиС Π°Π½Ρ‚ΠΈΠ³Π΅Π½Π° Π“ΠΈΡΠ‘Πœ1 Π² ΡΠΊΡΡ‚Ρ€Π°ΠΊΡ‚Π°Ρ… Ρ‚ΠΊΠ°Π½ΠΈ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… Π²ΠΎ Π²ΡΠ΅Ρ… исслСдованных случаях ΠΈ Π΅Π³ΠΎ отсутствиС Π² Ρ‚канях Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… Π»Π΅Π³ΠΊΠΈΡ… ΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°Ρ€Ρ†ΠΈΠ½ΠΎΠΌΡ‹ Π»Π΅Π³ΠΊΠΈΡ….

5. Π’ ΡΡ‹Π²ΠΎΡ€ΠΎΡ‚ΠΊΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΌ Ρ€Π°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΈΡ… присутствуСт Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ Π“ΠΈΡΠ‘Πœ1.

6. Π˜ΠΌΠΌΡƒΠ½ΠΎΡ„Π»ΡƒΠΎΡ€Π΅ΡΡ†Π΅Π½Ρ‚Π½ΠΎΠ΅ ΠΎΠΊΡ€Π°ΡˆΠΈΠ²Π°Π½ΠΈΠ΅ криостатных срСзов ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ² ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… продСмонстрировало ΡΠΊΡΠΏΡ€Π΅ΡΡΠΈΡŽ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π“ΠΈΡΠ‘Πœ1 Π² 85% ислСдований. Π”Π°Π½Π½Ρ‹ΠΉ Π°Π½Ρ‚ΠΈΠ³Π΅Π½ Π½Π΅ Π²Ρ‹ΡΠ²Π»Π΅Π½ Π² Ρ‚канях Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… Π»Π΅Π³ΠΊΠΈΡ…, Π°Π΄Π΅Π½ΠΎΠΊΠ°Ρ€Ρ†ΠΈΠ½ΠΎΠΌΠ΅ Π»Π΅Π³ΠΊΠΈΡ… ΠΈ ΠΎΠΏΡƒΡ…олях Π΄Ρ€ΡƒΠ³ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ.

7. Показана Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ выявлСния экспрСссии Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π•ΠΈΡΠ‘Πœ1 ΠΈΠ½Ρ‚Π΅Π³Ρ€ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΡƒΡŽ ΠΌΠ΅ΠΌΠ±Ρ€Π°Π½Ρƒ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π½ΠΎΠΉ модСльной систСмы.

8. ВысокоспСцифичСкиС ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π° Π•ΠΈΡΠ‘Πœ1 ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ для Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ тСст-систСм Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡ‚ΠΈΠΊΠ΅ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° Π»Π΅Π³ΠΊΠΈΡ… ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ иммунотоксичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ².

ΠŸΠΎΠΊΠ°Π·Π°Ρ‚ΡŒ вСсь тСкст

Бписок Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹

  1. Н. Π€. Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Π° ΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ². //НСйрохимия.-198 9.-Π’.8.-№ 3.-Π‘.433−451.
  2. М.Π . ИзмСнСния ΠΎΡ€Π³Π°Π½Π° зрСния Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ ΠΏΡ€ΠΈ ΠΎΠ±Ρ‰ΠΈΡ… заболСваниях КОЀ.-2001.-Π’.2.- № 4.-Π‘.14−24.
  3. Π­. Π’. Π“Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ‹ ΠΈ Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΊ Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π°ΠΌ сыворотки ΠΊΡ€ΠΎΠ²ΠΈ.//Биохимия-1992.-Π’.57.~ № 7.-Π‘.1004−1010.
  4. Π­. Π’. Π“Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Π½Ρ‹ΠΉ «ΡˆΠ΅Π΄Π΄ΠΈΠ½Π³» ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΠΊ.//ДАН.-198 3.-Π’.271.-№ 6.-Π‘.1511−1513.
  5. Π­. Π’., Π’Π΅ΠΊΠΈΠ΅Π²Π° Π•. А., ЛСмСновская А. Π€., Π‘ΠΎΠΌΠΎΠ²Π° О. Π“., Π‘Π΅Ρ€Π³Π΅Π»ΡŒΡΠΎΠ½ Π›. Π”. Π“Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄Ρ‹ GM3 ΠΈ GD3 Π² ΠΎΠΏΡƒΡ…олях ΠΆΠ΅Π»ΡƒΠ΄ΠΊΠ° ΠΈ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°.//Биохимия.-1995.-№ 3.-Π‘.560−564.
  6. О.Π€., ΠΡ€ΠΊΠ°Π΄ΡŒΠ΅Π² Π’. Π’. Π‘ΠΎΠ²Ρ€Π΅ΠΌΠ΅Π½Π½Ρ‹Π΅ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΠΈ Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… алкогольной Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡ‚ΡŒΡŽ.//Π–ΡƒΡ€Π½Π°Π» «ΠŸΡΠΈΡ…иатрия ΠΈ ΠΏΡΠΈΡ…офармакотСрапия». -2003.-Π’.05.-№ 4.-Π‘.7−9.
  7. .Π‘., Аврова Н. Π€., Π’Π°Π½ΡŒΠΊΠΎ Π›. Π’., Зарайский Π•.И.,. ΠΈ Π΄Ρ€. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… Π°Π½Ρ‚ΠΈΡ‚Π΅Π» ΠΏΡ€ΠΎΡ‚ΠΈΠ² Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Π³Π°Π½Π³Π»ΠΈΠΎΠ·ΠΈΠ΄ΠΎΠ².//Π‘ΡŽΠ»Π»Π΅Ρ‚Π΅Π½ΡŒ ΡΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹.-1986.-№ 1.-Π‘.66−68.
  8. Abbadi М El, Seyfried Π’ N, Yates A J, Orosz Π‘ and Lee ΠœΠ‘. Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse. //British Journal of Cancer.-2001.-V.85-P.285−292.
  9. Acquotti D. fie Sonnino S. Use of nuclear magnetic resonance spectroscopy in evaluation of ganglioside structure, conformation and dynamics.//Method Enzyology.-2000.-V.312.-P.247−272.
  10. Bassi Rosaria, Viani Paola, Tettamanti Guido, Riboni Laura. Effect of GM3 ganglioside on endothelin-mediated signal transduction in C6 glioma cells- Joint Symposia I.B.C.S.Y.// Biochemical S.-2000.-P.101−104 .
  11. Bast R.C. Editorial: Progress in radioimmunotherapy. //New Engl.J.Med.-1993.-P.1266.
  12. Bast R.C., De Fabritiis, Lipton J.. Elimination of malignant clonogenic cells from human bone marrow using multiple monoclonal antibodies and complement// Cancer Res.-1985.-V.45.-P.499−503.
  13. Bast R.C., Feeney M., Lazarus H.. Reactivity of a monoclonal antibody with human ovarian carcinoma. //J. Clin. Invest.-198l.-V.68.-№ 5.-P.1331−1337.
  14. Bernardi A., Arosio D. and Sonnino S. Mimicking gangliosides by design: mimics of GM1 headgroup. //Neurochem.-2002.-V.27.-P.539−545.
  15. Bernardi A., Carrettoni L., Grosso Ciponte A., Monti D. and Sonnino S. Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety.//Bioorg.-2000.-Med. Chem. Letters.-V.10.-P.2197−2200.
  16. Brocca P., Bernardi A., Raimondi, L. and Sonnino, S. Modeling Ganglioside Headgroups by Conformational Analysis and Molecular Dynamics.//Glycoconjugate J.-2000.-V.17.-P.289−299.
  17. Brockhaus M., Magnani J.C., Blaszczyk M., Stepkevski Z., Koprowski H., Karlsson K.A., Larsson G., Ginsburg V. Monoclonal antibodies directed against the human Le blood group antigen.//Biol. Chem.-V.256.-P.12 223−13 225.
  18. Brockhausen I., Lehotay M., Yang J.-M. et.al. Glycoprotein biosynthesis in porcine aortic endothelial cells and changes in the apoptotic cell population. //Glycobiology.-2002.-V.12(1).-P.33−45.
  19. Carey D. Cancer Therapy Despite Therapeutic Benefit -Physicians and patients alike are the accumulation of certain fats (gangliosides) in the brain and othertishue.//Cancer. -2004.-3(30).-P.125−136.
  20. Chen X.-P., Enioutina E.Y. and Daynis R.A. The control of IL-4 gene expression in activated murine T lymphocytes: a novel rol for neu-1 sialidase.// J. Immunol.-1997.-V.158.-P.3070−3080.
  21. Cheresh D.A., Honsir C. J., Statfileno L. K et.al. Disialoganglioside G03 on human melanoma serves as a relevant targets antigen for monoclonal antibody-mediated tumor cytolys is.//PNAS USA.-1985.- V.82.-P.5155−5159.
  22. Chia D., Terasari P.I., Suyama N. et.al.Use of monoclonal antibodies to sialylated Le and sialylated Le for serological tests of cancer.//Cancer Res.-1985.-V.45.-P.435−437.
  23. Chigorno, V., Palestini, P., Sciannamblo, M. T et.al. Evidence that ganglioside domains are distinct from and caveolae in MDCK and human fibroblast cells in culture. //Eur. J. Biochem.- 2000.-V.267.-P.4187−4197.
  24. Coombes R.Ch., Buckeman R., Ferrester J.A. et. al//. In vitro and in vivo effects of a monoclonal antibody-toxin conjugate for use in autologous bone marrow transplantation for patients with breast cancer. //Cancer Res.-1986.- V.46.-P.4217−4220.
  25. Delvillano B, Zuzawski W. The carboghydrat antigenic determinant 19−9 (CA 19−9):a monoclonal antibody defined tumor marker.//Immunodiagnostika.-1983.-P.269−282.
  26. Dettke M., PΓ‘ G.-lfi, and Loibner H. Activation-dependent expression of the blood grouprelated Lewis Y antigen on peripheral blood granulocytes J. Leukoc.//Biol.-2000.-V.68.-№ 4.-P.511−514.
  27. Dippold W.G., Dienes H.P., Knuth A. Immunohistochemical localization of ganglioside GD3 in human malignant melanoma, epithelial tumors, and normal tissues. //Cancer Res.-1985.-V.45.-P.3699−3705.
  28. Dippold W.G., Knuth A, Buschenfeide K. Ynhibition of Human melanoma Cell Growth in vitro by monoclonal anti-GD3-ganglioside antibody.//Cancer Research.- 1984.-V.44.-P.806−810.
  29. Dohi-T, Hashiguchi-M. Fucosyltransferase producing sialyl Le (a) and sialyl Le (x) carbohydrate antigen in gastrointestinal cancer.//Nippon-Rinsho.-1995.-V.53.-№ 7.-P.1781−1785.
  30. Douillard J.Y., Lehur P.A., Aillet G. Immunohistochemical antigenic expression and in vivo tumor uptake of monoclonal antibodies with specificity for tumors of the gastrointestinal tract. //Cancer Res.-1986.-V.46.-P.4221−4224.
  31. Drivsholm L. Vangsted A. PallesenT. Fucosyl-GMl in small-cell lung cancer. A comparison with the tumour marker neuron-specific enolase. //Ann-Oncol.-1994.-V.5.-№ 7.-P.623−626.
  32. Engval E., Porlman P. Enzyme-linked immunosorbent assay (ELISA), quantitative assay for immunoglobulin G.//Immunochem.-1971.-V.8.-P.871−874.
  33. Epenetos A.A., Kosmas C. Monoclonal antibodies for imaging and theray. //Brit.I.Cancer.-198 9.-V.59.-№ 2.-P.152−155.
  34. Fazecas de St. Groth, S., Scheidegger D. Production of monoclonal antibody. Strategy and tactics. //Immunol. Meth.-1980.-V.35.-P.1−21.
  35. Feld K., Gerrit D., Sacman N. Prognostic factors for small cell carcinoma of the lung. Evr. J. Clin. //Oncol.- 1988.-V.42.-P.353−355.
  36. Fredman P., Brezicka THolmgrenJ. Binding specificity of monoclonal antibodies to ganglioside, FucGMl.//Biochimica et Biophysica acta.-1986.-V.875.-P.316−323.
  37. Fucushi V, Hakomori S, Nudelman E, Cochran N.
  38. Novel fucolipids accumulating in human adenocarcinoma. 11
  39. Selective isolation of hibridoma antibodies thatdifferentially recognize mono, di and tri fucosylated type2 chain. J.//Biol. Chem.-1984.-V.259.-№ 7.-P.4681−4685.
  40. Fukushi J., Nudelman E., Levery S.B. Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6). //Biol. Chem.-1984.-V.259.-P.10 511−10 517.
  41. Guegan C. and Przedborski S. Programmed cell death in amyotrophic lateral sclerosis.//J. Clin. Invest.-January 15, 2003.-V.111.-«2.-P.153−161.
  42. Hakomori S. Glycosylation defining cancer malignancy: New wine in an old bottle. //PNAS.-2002.-V.99.- № 16.-P.10 231−10 233.
  43. Hakomori S. Glycosylation defining cancer malignancy.//J. Biol. Chem.-2002.-V.259.-P.4672−4680.
  44. Hakomori S. Gangliozids configuration durind cancermalignancy: New wine in an old bottle.//J. Natl. Cancer Inst.-2002.-V.71.-P.231−251.
  45. Hakomori S. Tumor-associated glycolipid antigens detined by monoclonal antibodies.//Bull Canar.-1983.-V.70.- № 2.-P.118−126.
  46. Hakomori S.-i. Inaugural Article: The glycosynapse. //PNAS.-2002.-V.99.-β„–l.-P.225 -232.
  47. Hakomori S.I. Tumor-associated glycolipid their metabolism and organization. //Chemistry and Physics of lipids.-1986.-V.42.-P.209−231.
  48. Hakomori S. Glycosylation defining cancer malignancy: New wine in an old bottle. //PNAS.-2002.-V.99.-β„–.16.-P.10 231−10 233.
  49. Hakomori S-I., Kannagi R. Glycosphingolipids as tumor-associated and differentiation markers.//"J. Nat. Cancer Inst.».-1983.-V.71.-№ 2.-P.231−251.
  50. Hakomori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. //Adv. Cancer Res.-1989.-V.52.-P.257−331
  51. Hakomori S. Kannagi R. Glycoshingolipids as tumor-associated and differentiation markers.//J. Natl. Cancer Inst.-1983.-V.71.-P.231−251.
  52. Hanai N.. Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung.//Cancer Res.-1986.-V.46.-P.4438−44 43.
  53. Hayashi I., Amano H., Yoshida S.et.al. Suppressed Angiogenesis in Kininogen-Deficiencies Lab.//Invest.-2002.-V.82.-№ 7.-P.871−880.
  54. Herr Ingrid, Debatin B. Cellular Klaus-Michael stress response and apoptosis in cancer therapy.//Blood.- 2001.-V.98.-P.2603−2614.
  55. Hiraishi K, Suzuki K, Hakomori S and Adachi M Le (y). Antigen expression is correlated with apoptosis (programmed cell death).//Glycobiology.-1993.-V.3.1. P.381−390.
  56. Hiraiwa N. Gangliosides and sialoglycoproteins carrying a rare blood group antigen determinant, Cad, associated with human cancers as detected by specific monoclonal antibodies.//Cancer Res.-1990.-V.50.-P.5497−5503.
  57. Hirashima, G. High idiotypic connectivity of the VH7183-encoded antibodies directed to a murine embryonic carbohydrate antigen, Lewis Y, as ascertained by syngenic anti-idiotype monoclonal antibodies.//J. Immunol.-1990.- V.145.-P.224−232.
  58. Hirota M., Fukushima K., Terasaki P.J.. Detection of tumor-associated antigens in the sera of lung cancer patients by three monoclonal antibodies. //Cancer Res.1985.-V.45.-P.6453−64 56.
  59. Houghton A.N., Scheinberg D.A. A Heteroclitic Peptide Vaccine Induces CD8+ T-Cell Responses to CD20.//Seminars in Oncology.-1986.-V.13.-№ 2.-P.165−179.
  60. Houghton A.N. Gangliosides in the oncological studies.//Oncology.-1985.-V.12.-№ 3.-P.24.
  61. Iliopoulos D., Ernst C., Steplewski Z. Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3gangliosides.//Journal Of The National Cancer Institute.-2004.-V.81.-P.440−444.
  62. Inaudi P., Pasqui G., Torre G.C. et.al. CA 125 and CA 19−9 in peritoneal, cyst and amniotic fluids.//Med. Oncol, and Tumor Abarmacofher.-1988.- V.5.- № 4.-P.233−238.
  63. Irie R.F., Morton D.L. Regression of cutaneous metastatic melanoma by intralesional injection with human monoclonal antibody to ganglioside GD2 //Proc. Natl. Acad. Sci. US.-1986.-V.83.-№ 22.-P.8 694−8698.
  64. Iwai K., Ishikura H., Kaji M.,. Importance of E-selectin (ELAM-1) and sialyl Lewis A in the adhesion of pancreatic carcinoma cells to activated endothelium.//Int. J. Cancer.-1993.- V.54.-P.972−977.
  65. Kanda N., Nakai K., and Watanabe S. Gangliosides GDlb, GTlb, and GQlb Suppress the Growth of Human Melanoma by Inhibiting Interleukin-8 Production: the Inhibition of Adenylate Cyclase.//J. Invest. Dermatol.-2001.-V.117.-№ 2.-P.284−293.
  66. Kaneko T. Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y. //J. Biochem.-1993.-V.113.-P.114−117.
  67. Kawashima I. H. Ozawa, M. Kotani. Characterizationof ganglioside expression in human melanoma cells: Immunological and biochemical analysis.//J.Biochem.-1993.-V.114.-P.186−193.
  68. Kawashima I. Immunocytochemical analysis of gangliosides in rat primary cerebellar cultures using specific monoclonal antibodies.//Brain Res.-1996,-V.732.-P.75−86.
  69. Kawashima I. Identification of HLA-A3-restricted Cytotoxic T Lymphocyte Epitopes from Carcinoembryonic Antigen and HER-2/neu by Primary in Vitro Immunization with Peptide-pulsed Dendritic Cells.//J.Biochem.-1993.-V.114.-P.186−193.
  70. Kawashima I. Ganglioside in human melanoma cells.//J.Biochem.-1992.-V.113.-P.123−125.
  71. Kawashima I. Telomerase-Specific Replication-Selective Virotherapy for Human Cancer.//Brain Res.-1996.-V.732.-P. 75−86.
  72. Kohler G., Milstein C. Continious cultures of fused cells secreting antibody of predefined specificity. //Nature.-1975.-V.256.- № 55.- P.495−497.
  73. Koprowski H., Steplewski Z., Mitchel K et. al Colorectal carcinoma antigens detected by hybridoma antibodies.//Cell Genet.- 1979.-V.5.-P.957−972.
  74. Kotani M. Developmental changes of ganglioside expressions in postnatal rat cerebellar cortex.//Brain Res.-1995.-V.700.-P.40−58.
  75. Kotani M. Generation of one set of monoclonal antibodies specific for a-pathway ganglio-series gangliosides.//Biochim. Biophys. Acta.-1992.- V.1117.-P.97−103.
  76. Kotani M, Hosoya H, Kubo H, et.al.Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts.//CellStruct.Funct.-l994,Apr.-V.19(2).-P.81.
  77. Kotani M, Kawashiraa I, Ozawa H et.al.Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodies.// Glycobiology.-1993- V.3.-P.137−146.
  78. Kotani K., Kotani K., Hara K., et.al.Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase.// Biochemical and Biophysical Research Communications.-1995 .-V.208.- P.735−741.
  79. KotaniY., Matsuda S., Sakanaka, M.et.al. Prosaposin facilitates sciatic nerve regeneration in vivo.// J. Neurochem.-1996.-V.66.-P.2019−2025.
  80. Kotani, M. Immunohistocehmical localization of minor gangliosides in the rat central nervous system. //Glycobiology.-1994.-V.4.-P.855−8 65
  81. Kubo, H. Differential distribution of ganglioside GM1 and sulfatide during the development of Xenopus embryos.//Develop.Growth.Differ.-1995.-V.37.-P.243−255.
  82. Larson S.M. Radiolabeled monoclonal anti-tumor antibodies in diagnosis and therapy, nucl. //Med.-1985.-V.26-P.538−545
  83. Leahy J.L. Vanderkerkhove K. M. Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion. // Endocrinology.-1990 .-V.126, N3.-P.1593−1598
  84. Ledermann J. A., Begent R.H.J., Keep P.A. et.al. The human antibody response to radiolarelled antibodies for tunour therapy. //6th Int. Congr. Immunol., Toronto, 1. July 6−11, 1986.-P.545.
  85. Loberto N, Prioni S, Ottico E. et.al. The adesion protein TAG-1 has a ganglioside environment in the sphingolipid enriched membrane domains of neuronal cells in culture. //J. Neurochem.- 2003.- V.85.-P.224−233.
  86. MΓΌ J., Burg M., MΓΆ B, et.al. Preferential binding of the anticancer drug rViscumin (recombinant mistletoe lectin) to terminally 2−6-sialylated neolacto-series gangliosides.//Glycobiology Abstracts: Müathing.-2001.-V.8.-P.485
  87. Marechal F., Berthiot G., Deltour G. Sezam levels of CA-50, CA-125, CA15.3, enolas and carcino-embryonic antigen in non neoplastic diseases of the lung. //Anticancer Res.- 1988.-V.8, № 4.-P.677−680.
  88. Martino S, Cavalieri C., Emiliani C. et.al. Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from a Tay-Sachs disease animal model. //Neurochem. Res.- 2002.-V.2.-P.793−800.
  89. Martino S, Emiliani C, Tancini B. et.al. Absence of metabolic cross-correction in Tay-Sachs cells: implications for gene therapy.//J Biol Chem.- 2002.-V.277.- P.20 177−20 184.
  90. Masserini M, Palestini P, Pitto M, Chigorno V and Sonnino S Preparation and use of liposomes for the study of sphingolipid segregation in membrane model systems. //Methods in Molecular Biology.-2002.-V.199.-P.17−27.
  91. Masserini M., Ravasi D. and Sonnino S. Role of glycosphingolipids in formation and function of membrane microdomains. //Trends Glycosc. Glycotech.- 2001.-V.13.-P.239−250.
  92. Maura N. Dickler, Govindaswami Ragupathi, Nancy X. Liu et.al. Grant Immunogenicity of a Fucosyl-GMl
  93. Keyhole Limpet Hemocyanin Conjugate Vaccine in Patients with Small Cell Lung. //Cancer Clinical Cancer Research.- October 1999.- V.5.- P.2773−2779
  94. Mauri L, Prioni S, Loberto N. et.al. Synthesis of radioactive and photoactivable ganglioside derivatives for the study of ganglioside-protein interactions. //Glycoconjugate J.- 2003.- in press.
  95. Mauri L, Valsecchi M, Casellato R. et.al. Procedure for the separation of the GM2 ganglioside species with different ceramide structures by flash reversed-phase silica gel liquid chromatography. //J. Chromatog B.- 2003.- in press.
  96. Miljan E. A., Meuillet E. J., Mania-Farnell B. et.al. Interaction of the Extracellular Domain of the Epidermal Growth Factor Receptor with Gangliosides. //J. Biol. Chem.- March 22, 2002.- V.277,№ 12.-P.10 108 -10 113.
  97. Minasian-LM, Yao-TJ, Steffens-TA. et.al.A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma. //Cancer.-1995 May 1.- V.75,№ 9.- P.2251−2257.
  98. Miyake M.. Generation of two murine monoclonal antibodies that can discriminate N-acetyl neuraminic acid residues of GM2 ganglioside. //Cancer Res.- 1988.-V.48.- P.6154−6160.
  99. Miyake M Adachi M, Taki T, et.al.Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer.// Cancer Research.- 2002 .-V.56.- .P.1751−1755.
  100. Miyake M. The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors.//Cancer.-1990.- V.65.-P.499−505.
  101. Miyake Y., Nakamura S., Kozutsumi Y. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2.//J. Biol. Chem.-1996.-V.271.-P.1255−1257.
  102. Mulchine J.L., Cuttitta F., Bibro M. Identification of vasoactive nonpeptidic positive and negative modulators of adrenomedullin using a neutralizing antibody-based screening strategy.//J. Immunol.- 1983.- V. 131.- P.497−502.
  103. Munck-Wikland E., Kuylenstierna R., Wahren B. Prognostic and predictive markers for cancer and dysplasias of the head and neck //Cancer.- 1988.-V. 62.-P.2281−2286.
  104. NaKane P, Hiroshi Nakane- Francis JHeis et.al. Gene Transfer of Endothelial Nitric Oxide Synthase Reduces Angiotensin II-Induced Endothelial Dysfunction Hypertension. // J. Biol. Chem.- 2000.-V.35.-595.-P.7−9.
  105. Nakane P.K., Kawaoi A. Enzyme-labeled antibodies preparation and application for the localization of antigens.//J.Histochem.Cytochem.-1974.-V.22.-P.1084−1091.
  106. Nilsson 0., Brezicka T., Holmgren. Detection of gangliosideantigen associated with small cell. carcinomas using monoclonal antibodies directed agaj Fucosyl-GMl.//Cancer Research.-1986.-V.48.-P.14 03−14 07.
  107. Nojiri Hisao, PhD, Yamana Hideaki, MD, Shirouzu Genzan, MD. et.al. Glycotherapy for cancer: remodeling of ganglioside pattern as an effective approach for cancer therapy. //Cancer Detection and Prevention.-2002.-V.26(2).-P.75−76.
  108. North P. E., Waner M., Mizeracki A. et.al. Jr A Unique Microvascular Phenotype Shared by Juvenile Hemangiomas and Human Placenta Arch Dermatol.// Cancer.
  109. May 1, 2001.-V.137(5)P.559 570.
  110. Ogata S., Ho I., Chen A. T et.al. umor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. //Cancer-Res.- 1995 May 1.-V.55 (9) .- P.1869−74.
  111. Ohta S., Tsukamoto H., Watanabe K. et.al. Tumor-associated glycoantigen, sialyl Lewis (a) as a target for bispecific antibody-directed adoptive tumor immunotherapy. //Immunol-Lett.-1995 Jan.-V.44(1).-P.35−40
  112. Ono M., Handa K., Sonnino S. et.al. GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: co-expression of GM3 and CD9 is essential in down-regulation of tumor cell motility and malignancy. //Biochemistry.- 2001.- V.40.- P.6414−6421.
  113. Ottico E, Prinetti A, Prioni S Dy et.al.
  114. Namics of lipid membrane domains in cultured cells.// J. Lipid Res.- 2003.- in press.
  115. Posmus P.E., CJ Hirschler-Schulte, BS Hylkema, and RW Meyer. Mechanical ventilation for acute postoperative respiratory failure after surgery for bronchial carcinoma. //Thorax.- May 1985.-V.40.-P. 387 390.
  116. Posmus P.E., Hirschler-Schulte T.J.W., De Leij L. Mechanical ventilation for acute postoperative respiratory failure after surgery for bronchial carcinoma //Cancer.- 1986.- V.57.- P.60−63.
  117. Prinetti A., Chigorno V., Prioni S. et.al. Changesin the lipid turnover, composition and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro. //J. Biol. Chem.- 2001.-V.276.- P.21 136−21 145.
  118. Prinetti A., Marano N., Prioni S. et.al. Association of Src-family protein tyrosine kinases with sphingolipids in rat cerebellar granule cells differentiated in culture. //Glycoconjugate J.-2000.-V.17.- P.223−232.
  119. Prinetti, A., Chigorno, V., Tettamanti, G. and Sonnino, S. Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture: a compositional study. //J. Biol. Chem.- 2000.-V.275.-P.11 658−11 665.
  120. Prinetti, A., Basso, L., Appierto, V. et.al. Altered sphingolipid metabolism in N-(4-hydroxyphenyl)retinamide-resistant A2780 human ovarian carcinoma cells. //J.Biol.Chem.- 2003.-V.278.-P.5574−5583.
  121. Prioni S., Loberto N., Prinetti A.et.al. Sphingolipid metabolism and caveolin expression in gonadotropin-releasing hormone-expressing GNU and gonadotropin-releasing hormone-secreting GT1−7 neuronal cells. //Neurochem. Res.- 2002.-V.27.- P.831−840.
  122. Ranes M.K., El-Abbadi M., Manfredi M.G.et.al. Nbutyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours. //British Journal of Cancer.- 2001.-V.84.- P.1107−1114.
  123. Reisfeld Ralph A., Cheresh David A. Human tumor antigens.//Immunol. -1987.- V.40.- P.323−377.
  124. Rizzo A.M., Rossi F., Guerra A. et.al. Exogenous sphingosine is taken up and metabolised by Xenopus laevis embryos grown in Petri dishes. //Bioscience Rep.-2001.-In press
  125. Rizzo AM, Berra B, Rossi F. et.al. Structure of the main ganglioside from the brain of Xenopus Laevis. //Glycoconjugate J.-2002.-V.19.- P.53−57.
  126. Rubenstein K.F., Schneidein K.E., Huisjen J., Ullman E.F. Mechanism by immunoassay. New Immunochemical technique Biochem. //Biophis. Res. Commun.- 1972.-V.47.- P.846−851.
  127. A. H. Rubenstein, PM Blix, D.L. Horwitz, D.F. Steiner. Cell Cycle Regulation of Menin Expression. //Diabetes.- 1977.-V.26.-P. 22−29.
  128. Satoh, M-Ito, A-Nojiri et.al. GM3 expression, associated with decreased invasiveness, is induced by brefeldin A in bladder cancer cells. //INTERNATIONAL JOURNAL OF ONCOLOGY.- OCT 2001.-V.19(4).-P.723−731.
  129. Schultz G., Cheresh D.A., Varki N.M. et. al Detection of ganglioside GD2 in tumor tissue and sera of neuroblastoma patients. //Cancer Res.- 1984.-V.44.-P.5914−5920.
  130. Sciannamblo M., Chigorno V., Passi A. et.al. Changes of the ganglioside pattern and content in human fibroblasts by high density cell population subculture progression. //Glycoconjugate J.- 2002.-V.19.- P.181−186.
  131. Sears H.F., Herlyn D., Steplewsli Z. Identificationof the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19−9 in the sera of patients as a mucin. //Cancer Res.- 1985.-V. 45.-P.5910−5913.
  132. Senger Donald R., Claffey Kevin P., Benes Julie E. et. al Angiogenesis promoted by vascular endothelialgrowth factor: Regulation through
  133. Seppala M., Taylor R. N., Koistinen H. et. al Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation Endocr. //Rev.- August 1, 2002.-V.23(4).- P.401 430.
  134. Seppo Antti, Matani Parul, Sharrow Mary and Tiemeyer Michael. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. //Development.-2003.-V.130.- P.1439−1448.
  135. Shamshiev A., Donda A., Prigozy T.I.et.al.The Pa T cells response to self-glycosphingolipids shows a novel mechanism of CDlb loading and requirement for complex oligosaccharides. //Immunity.- 2000.-V.13.-P.255−264.
  136. Shitara, K. Distribution of lung adenocarcinoma-associated antigens in human tissues and sera defined by monoclonal antibodies KM-52 and KM-93. //Cancer Res.-1987.-V.47.-P.1267−1272.
  137. Shurin G. V., Shurin M. R., Bykovskaia S. A et.al. Neuroblastoma-derived Gangliosides Inhibit Dendritic Cell Generation and Function. //Cancer Research.-January 1, 2001.-V.61.- P.363−369.
  138. Sieri K., Kiruchi Y., Uesato K., Kato K Yncreased sezam CA 125 levels daring the first trimester ofpregnansy. //Acta obstet. gynaecol. Scand.- 1986.-V.65.-P.583−585.
  139. Smets Lou A. Tumor cell curfasecarbohydrates: genetic control and phenotypic implications.//"Membranes Tumor Growth. Proc. Int. workshop, Rome, June 14−18, 1982″. Amsterdam e.a.- 1982.- P.139−147.
  140. Sonnino S. Forward. Special issue on sphingolipids dedicated to Professor Guido Tettamanti, Neurochem. //Res.- 2002.-V.27.- P.537−538.
  141. Sonnino S. and Chigorno V. Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissue and neuronal cell cultures. //Biochim. Biophys.- 2000.- V.469.- P.63−77.
  142. Sonnino, S. and Tettamanti, G. (Guest Editors). Glycosphingolipids and membrane domains. //Glycoconjugate J.- 2000.-V.17.- P.141.
  143. Sonnino, S., Chigorno, V. and Tettamanti G. Preparation of radioactive gangliosides, 3H. or [14C] isotopically labeled at the oligosaccharide or ceramide moieties. //Method Enzym.- 2000.-V.311.- P.639−656.
  144. Steplewsri Z., Spira G., Blaszczyr M. et.al. Scharff Isolation and characterization of anti-monosialoganglioside monoclonal antibody IS-9 class-switch variants. //PNAS.- 1985. V.82.-P.8653−8657.
  145. Suikkari A., Koivisto U., Rutanen Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein //E.Ibid.-1988.-V.66.-P.266−272.
  146. Sun P., Wang X.Q., Lopatka K., Bangash S., and Paller A. S. Ganglioside Loss Promotes Survival Primarily by Activating Integrin-Linked Kinase/Akt Without Phosphoinositide 3-OH Kinase Signaling //J. Invest. Dermatol.- July 1, 2002.-V.119(1).-P.107−117.
  147. Sung-C.C., Pearl D.K., Coons S.W., Scheithauer B.W., Johnson P.C., Yates A.J. Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors. //Cancer.-1994 Dec l.-V.74(11).-P.3010−22.
  148. Tai T. Cell type-specific expression of ganglioside antigens in the central nervous system. Pure and Appl. //Chem.- 1997.-V.69.- P.1903−1910.
  149. Tai, T. Head, Department of Tumor Immunology. //The Tokyo Metropolitan Institute of Medical Science.-1999.-P.34−37.
  150. Tai, T. Generation of a monoclonal antibody specific for ganglioside GM4. //PudMed.-1993.-P.123−141.
  151. Takada, A..: Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A. //Biochem. Biophys. Res. Commun.-1991.-V.179.-P.713−719.
  152. Takada A. Epstein-Barr Virus and Cancer. //Clin Cancer Res.-2004.-V.10.-P.803.
  153. Takada A. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. //Cancer Res.-1993.-V.53.-P.354−361.
  154. Takada, A. Therefore, antibodies against carbohydrate antigens of donor kidney can be presented in the recipient’s blood //Nature.1994.—V.372.-P.7.
  155. Tockman M., Gupta R.K., Myers J.D. Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression. //J. Clin. Oncol.- 1988.-V. 6(11).-P.1685−1693.
  156. Tong A.W., Lee J., Stone M.J. Quantitative Epstein-Barr Virus DNA Analysis and Detection of Gene Promoter Hypermethylation in Nasopharyngeal (NP) Brushing Samples from Patients with NP Carcinoma//Cancer Res.- 1984.-V.44.- P.4987−4992.
  157. Treleaven J. G., Gibson F. M., Ugelstad J. et.al.Removal of neuroblastoma cells from bone marrow with monoclonal antibodies conjugated to magnetic microspheres. J., Philip T.. //Lancet.- 1984.- p.70−73.
  158. Tsuji, T. Prognostic Significance of CEA, CA 19−9 and CA 72−4 Preoperative Serum Levels in Gastric Carcinoma//Anticancer Res.- 1989.-V.9.- P.327−340.
  159. Ugur 0, Scott A. M, Kostakoglu L, et.al.Calculated and TLD-based absorbed dose estimates for I-131-labeled 3F8 monoclonal antibody in a human neuroblastoma xenograft nude mouse model. //Nucl-Med-Biol.- 1995 Jan.-V.22(1).- P.87−93.
  160. Valiente 0., Mauri L., Casellato R.,. Fernandez L. E and Sonnino S. The preparation of deacetyl-, lyso-and deacetyl-lyso-GM3 by selective alkaline hydrolysis of GM3 ganglioside. //J. Lipid Res.- 2001.-V.42.-P.1318−1324.
  161. Vangsted Annette, Drivsholm Lars, Andersen Elo, Pallesen Tina, Zeuthen Jesper, Wallin Hakan, New Serum Markers for Small-Cell Lung Cancer I. The Ganglioside Fucosyl-GM (l). //Published in Cancer Detection and Prevention.- 1994 .-V.18 (3).-P.221−230.
  162. Vangsted A.J. Serological tumor markers for small cell lung cancer and their therapeutic implications. //APMIS.-1994 Aug.-V.102(8) .-P.561−80
  163. Vangsted A.J. Correlation with bladder cancer risk.
  164. Cancer Res.- 1991.-V.51.-P.2762.
  165. Wang X.Q., Sun P. and Paller A. S. Ganglioside GM3 Inhibits Matrix Metalloproteinase-9Activation and Disrupts Its Association with Integrin. //J. Biol. Chem.- July 11, 2003.-V.278(28).- P.25 591 25 599.
  166. Wang X.Q., Sun P. and Paller A. S. Ganglioside Induces Caveolin-1 Redistribution and Interaction with the Epidermal Growth Factor Receptor. //J. Biol. Chem.-December 6, 2002.-V.277(49).-P.47 028−47 034.
  167. Wang X.Q., Sun P. and Paller A. S. Ganglioside Modulation Regulates Epithelial Cell Adhesion and Spreading via Ganglioside-specific Effects on Signaling. //J. Biol. Chem.- October 25, 2002.-V.277(43).- P.40 410−40 419.
  168. Wang X.Q., Sun P. and Paller A. S. Inhibition of Integrin-linked Kinase/Protein Kinase B/Akt Signaling. MECHANISM FOR GANGLIOSIDE-INDUCED APOPTOSIS. //J. Biol. Chem.- November 30, 2001.-V.276(48).-P.44 504−44 511.
  169. Watari, S. Application of liposomes to generation of monoclonal antibody to glycosphingolipid: Production of monoclonal antibody to GgOse4Cer. //J. Biochem.-1987 .- V. 102.- P.59−67.
  170. Watty A. and Burden S. J. MuSK Glycosylation Restrains
  171. MuSK Activation and Acetylcholine Receptor Clustering. //
  172. J. Biol. Chem.-December 27,2002. V. 277(52).- P.5 045 750 462.
  173. Weiss M., Hettmer S., Smith P., and Ladisch S. Inhibition of Melanoma Tumor Growth by a Novel Inhibitor of Glucosylceramide Synthase.//Cancer Res.-July 1,2003,1. V.63(13).- P.3654−3658.
  174. Wilkins J.R., D’Ercole A.J. Affinity-labeled plasma somatomedin-C/Ynsulinlike growth factor 1 binding proteins. //J. Clin. Chim. Invest.- 1985.- V.75(4).-P.1350−1358.
  175. Yamanda-T., Haniuda-M., Iida-F., Kannagi-R. Immunohistochemical expression of sialyl-Lewis antigens in lung cancer. //Nippon-Rinsho.- 1995 Jul.- V.53(7).-P.1776−1780.
  176. Yamashina I. Carbohydrate-directed monoclonal antibodies and their use in cancer diagnosis. //Published in Cancer Detection and Prevention.-1995.-V.19(1).-P.4.
  177. Zecca L., Costi P., Mecacci C et.al.Interaction of human substantia nigra neuromelanin with lipids and peptides. //J. Neurochem.- 2000.-V.74.-P.1758−1765.
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