ΠΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°ΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ²
ΠΠ°ΡΡΠ΄Ρ Ρ ΡΡΠΈΠΌ Π²Π΅Π΄Π΅ΡΡΡ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Π·Π° ΡΡΠ΅Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΠΊ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ-ΠΌΠΈΡΠ΅Π½ΡΠΌ ΠΈΠ»ΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈΡΡΡΡΠΈΠΌΠΈ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌΠΈ. ΠΡΠΎΠ±ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΈΠΎΠ½ΠΎΡΠΎΡΠ½ΡΠΉ Π°Π³Π΅Π½Ρ ΠΌΠΎΠ½Π΅Π½ΡΠΈΠ½, Π±ΡΠ΅ΡΠ΅Π»Π΄ΠΈΠ½, Π ΠΈ Ρ Π»ΠΎΡΠΈΠ΄ Π°ΠΌΠΌΠΎΠ½ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅, ΠΈΠ·ΠΌΠ΅Π½ΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Π°, ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ ΠΏΡΠΎΡΠ΅Π½Ρ Π΄Π΅Π³ΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π²ΡΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ». ΠΡΠΈ ΡΡΠΎΠΌ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- ΠΠ»Π°Π²Π° 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- 1. 1. Π Π°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠΎΠΊΡΠΈΠ½Ρ
- 1. 1. 1. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠΈΡΠΈΠ½Π°
- 1. 1. 2. Π’ΠΎΠΊΡΠΈΠ½Ρ Viscum album
- 1. 1. 3. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Ρ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΡΡ ΠΈ ΠΈΡ ΠΈΠ½ΡΠ΅ΡΠ½Π°Π»ΠΈΠ·Π°ΡΠΈΡ
- 1. 1. 4. ΠΠ½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΏΡΡΡ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ²
- 1. 2. CD5 Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΡΠΉ Π°Π½ΡΠΈΠ³Π΅Π½ ΠΊΠ°ΠΊ Π²Π΅ΠΊΡΠΎΡ Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ²
- 1. 2. 1. CD5 Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΡΠΉ Π°Π½ΡΠΈΠ³Π΅Π½
- 1. 2. 2. ΠΠ½ΡΠΈ-Π‘Π5 Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Ρ Π½Π° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅
- 1. 3. Π’ΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Ρ Π½Π° Π΅Π³ΠΎ ΠΎΡΠ½ΠΎΠ²Π΅
- 1. 3. 1. Π’ΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½
- 1. 3. 2. Π’ΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ΠΎΠ²ΡΠΉΡΠ΅ΡΠ΅ΠΏΡΠΎΡ
- 1. 3. 3. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π°
- 1. 3. 4. ΠΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΠΈ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π’ΡΠ
- 1. 4. ΠΠ»ΠΈΠΎΠΌΡ
- 1. 5. ΠΠ΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ²
- 1. 6. ΠΠΎΠ½Π΅Π½ΡΠΈΠ½ ΠΈ Π΄ΡΡΠ³ΠΈΠ΅ Π°Π³Π΅Π½ΡΡ, ΡΡΠΈΠ»ΠΈΠ²Π°ΡΡΠΈΠ΅ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΠΠ’
- 1. 1. Π Π°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠΎΠΊΡΠΈΠ½Ρ
ΠΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°ΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΠ±ΠΎΡΠΎΠΌ-ΠΈΠ½Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² II ΡΠΈΠΏΠ° ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π°ΡΠ»ΠΈ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅, ΠΊΠ°ΠΊ Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΉ, ΡΠ°ΠΊ ΠΈ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΈ ΠΏΡΠΈ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΊΠ°Π½Π΅ΠΉ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠΌΠΈ Π²Π΅ΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠΈ ΡΠΈΠ½ΡΠ΅Π·Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΡΠ²Π»ΡΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π°. ΠΠ΄Π½Π°ΠΊΠΎ Π½Π΅ Π΄Π»Ρ Π²ΡΠ΅Ρ ΡΠΈΠΏΠΎΠ² ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΡΠ΄Π°Π»ΠΎΡΡ Π½Π°ΠΉΡΠΈ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ»ΠΈ Π±Ρ ΡΠ½ΠΈΡΡΠΎΠΆΠ°ΡΡ 100% Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π±Π΅Π· ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ ΡΡΡΠ΅ΠΊΡΠΎΠ². ΠΠΎΠΈΡΠΊ Π½ΠΎΠ²ΡΡ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ² ΠΈ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΊΠ»ΡΡΠ΅Π²ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΈ ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. ΠΠΎΠ»ΡΡΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠΌ ΡΡΡΠ΅ΠΊΡΠ°ΠΌ ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² in vivo ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌ ΠΈΡ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ. ΠΠ΅Π· ΡΠΎΠΌΠ½Π΅Π½ΠΈΡ, ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΡΡΠΎΠΊΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΎΡΠΈΡΡΠΊΠ° Π²ΡΠ΅Ρ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ². Π’Π°ΠΊΠΆΠ΅ Π½ΠΈΠ²Π΅Π»ΠΈΡΠΎΠ²Π°ΡΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π·Π° ΡΡΠ΅Ρ Π³ΡΠΌΠ°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΡΡΠΈΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π», Π½Π°Ρ ΠΎΠ΄ΡΡΠΈΡ ΡΡ Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ², ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΠΎΡΠΌ ΡΠΈΠ±ΠΎΡΠΎΠΌ-ΠΈΠ½Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΈΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ», ΡΠ°ΠΊΠΈΡ ΠΊΠ°ΠΊ ΠΏΡΠΎΡΠ΅Π°Π·Ρ, ΠΎΠΊΡΠΈΠ΄ΠΎΡΠ΅Π΄ΡΠΊΡΠ°Π·Ρ, ΠΠΠΠ°Π·Ρ, Π ΠΠΠ°Π·Ρ.
ΠΠ°ΡΡΠ΄Ρ Ρ ΡΡΠΈΠΌ Π²Π΅Π΄Π΅ΡΡΡ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Π·Π° ΡΡΠ΅Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΠΊ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ-ΠΌΠΈΡΠ΅Π½ΡΠΌ ΠΈΠ»ΠΈ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈΡΡΡΡΠΈΠΌΠΈ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌΠΈ. ΠΡΠΎΠ±ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΈΠΎΠ½ΠΎΡΠΎΡΠ½ΡΠΉ Π°Π³Π΅Π½Ρ ΠΌΠΎΠ½Π΅Π½ΡΠΈΠ½, Π±ΡΠ΅ΡΠ΅Π»Π΄ΠΈΠ½, Π ΠΈ Ρ Π»ΠΎΡΠΈΠ΄ Π°ΠΌΠΌΠΎΠ½ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅, ΠΈΠ·ΠΌΠ΅Π½ΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Π°, ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ ΠΏΡΠΎΡΠ΅Π½Ρ Π΄Π΅Π³ΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π²ΡΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ». ΠΡΠΈ ΡΡΠΎΠΌ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΊΠ°ΠΊ Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠ°ΠΊ ΠΈ in vivo.
Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ in vitro ΠΈ in vivo.
ΠΠ»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠΉ ΡΠ΅Π»ΠΈ Π±ΡΠ»ΠΈ ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π·Π°Π΄Π°ΡΠΈ:
1.ΠΠΎΠ»ΡΡΠΈΡΡ ΠΠ’ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π’Ρ ΠΈ Π°Π½ΡΠΈ-CDS ΠΌΠΎΠ½ΠΠ’.
2.ΠΠΎΠ»ΡΡΠΈΡΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΡ, ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΠΈΠ΅ ΠΌΠΎΠ½ΠΡ ΠΏΡΠΎΡΠΈΠ² Π-ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΡ ΡΠΈΡΠΈΠ½Π° (RTA).
3.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΠ’ in vitro ΠΈ ex vivo Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ-ΠΌΠΈΡΠ΅Π½ΠΈ.
4.ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΠΎ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠΌΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΠ’ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π’Ρ Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈΡΡΡΡΠΈΠΌΠΈ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌΠΈ.
5. ΠΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°ΡΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΠ’ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ affra-CD5 ΠΌΠΎΠ½ΠΠ’.
ΠΡΠ²ΠΎΠ΄Ρ.
1. ΠΠΎΠ»ΡΡΠ΅Π½Ρ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΠΈ aCD5 ΠΌΠΎΠ½ΠΡ Ρ Π-ΡΠ΅ΠΏΡΠΌΠΈ ΡΠΈΡΠΈΠ½Π° ΠΈ Π²ΠΈΡΠΊΡΠΌΠΈΠ½Π°.
2. ΠΠΎΠ»ΡΡΠ΅Π½Ρ ΠΈ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ ΠΌΠΎΠ½ΠΠ’ ΠΊ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π-ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅ ΡΠΈΡΠΈΠ½Π°. ΠΠ° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΎΠ·Π΄Π°Π½Π° ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΠ° Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΡΠΈΡΠΈΠ½Π° Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ ΠΈ ΠΠ’ Π½Π° Π΅Π³ΠΎ ΠΎΡΠ½ΠΎΠ²Π΅.
3. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ in vitro ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ex vivo.
4. Π‘ΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ’ Ρ ΠΈΠΎΠ½ΠΎΡΠΎΡΠ½ΡΠΌ Π°Π³Π΅Π½ΡΠΎΠΌ ΠΌΠΎΠ½Π΅Π½ΡΠΈΠ½ΠΎΠΌ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠ’.
5. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ, ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° aCD5/RTA ΠΎΡΠΎΡΠΌΠ»Π΅Π½Ρ Π² Π²ΠΈΠ΄Π΅ ΠΏΡΠΎΠ΅ΠΊΡΠ° ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΏΠ΅ΠΉΠ½ΠΎΠΉ ΡΡΠ°ΡΡΠΈ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ Π½Π° ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΡΠΈΡΡΠ°ΡΠΈΠ½ 5.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅
.
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Ρ Π·Π°Π½ΡΠ»ΠΈ Π²Π°ΠΆΠ½ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΈ ΡΠΈΡΠΎΠΊΠΎ Π²ΠΎΡΠ»ΠΈ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ. ΠΠ°ΠΌΠ΅Π½Π° ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅ΠΉ ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΡ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ»ΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΊΡΠΈΠ½Π° Π½Π° ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π°Π½ΡΠΈΡΠ΅Π»ΠΎ ΠΈΠ»ΠΈ ΡΠ°ΠΊΡΠΎΡ ΡΠΎΡΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΠ·ΠΌΠ΅Π½ΠΈΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΏΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΡ, ΡΠΌΠ΅Π½ΡΡΠΈΡΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡ Π΅Π΅ Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΠΈ Π² Π»ΠΈΠ·ΠΎΡΠΎΠΌΠ°Ρ ΠΈ Π·Π° ΡΡΠ΅Ρ ΡΡΠΎΠ³ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΊΠ»Π΅ΡΠΊΡ-ΠΌΠΈΡΠ΅Π½Ρ. ΠΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π°ΡΠΈΠ²Π½ΡΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΈΠ»ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π½Π° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π΅Ρ ΡΡΠ΅Π·Π²ΡΡΠ°ΠΉΠ½ΠΎ Π²Π°ΠΆΠ½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ, Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΡ Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π²ΡΡΠΎΠΊΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ².
Π Ρ ΠΎΠ΄Π΅ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΠΈ Π-ΡΠ΅ΠΏΠ΅ΠΉ ΡΠΈΡΠΈΠ½Π° ΠΈ Π²ΠΈΡΠΊΡΠΌΠΈΠ½Π°. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΊ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Ρ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΊΠ°ΠΊ Π½Π° ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ, ΡΠ°ΠΊ ΠΈ Π½Π° ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π»ΠΈΠ½ΠΈΠΈ Jurkat, Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ MNA9 ΠΈ RchAl, ΠΈ Π½Π΅ Π±ΡΠ» ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ Π½Π° ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π»ΠΈΠ½ΠΈΠΈ Daudi. Π Π°Π·Π»ΠΈΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΈ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π² ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Π° ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ. Π’Ρ ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°Ρ Π’Ρ/RTA, ΠΌΠ΅ΡΠ΅Π½Π½ΡΠ΅ FITC Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π»ΠΈ Ρ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π³Π»ΠΈΠΎΠΌΡ ΡΡΠ°ΠΌΠΌΠ° 101−8. Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠ²Π΅ΡΠ΅Π½ΠΈΡ Π½Π° ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π±ΡΠ» Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π½Π° Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΌΠΎΠ·Π³Π°, ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΏΡΠΈ ΠΌΠ°Π»ΠΈΠ³Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΊ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½Ρ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΎΠ·Π³Π° ΠΊΡΡΡΡ Π±ΡΠ»ΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ Π΄Π°Π½Π½ΡΠΌΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ.
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠ½ΡΡ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ²-ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎΠ± ΡΡΠΎΠ²Π½Π΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΊ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π°ΠΌ Π½Π° ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠΈΠ½ΡΠ΅Π·Ρ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ².
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π΄Π°Π½Π½ΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ-ΠΌΠΈΡΠ΅Π½ΠΈ in vitro ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΠΠ50 Π΄Π»Ρ ΠΎΠ±ΠΎΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΎΠ΄ΠΈΠ½Π°ΠΊΠΎΠ²Π° ΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 5×10″ 9 Π. ΠΠ»Π΅ΡΠΊΠΈ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌ, ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΏΡΠΎΡΠΈΠ² ΡΠΈΡΠΈΠ½Π° ΠΈ Π²ΠΈΡΠΊΡΠΌΠΈΠ½Π° ΠΈ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΠ΅ ΠΊ ΠΈΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π½Π΅ΡΡΡΠΎΠΉΡΠΈΠ²ΡΠΌΠΈ ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π-ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡ ΡΡΠΈΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ². ΠΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅Ρ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΏΡΡΡ, ΠΊΠ°ΠΊ Π½Π°ΠΏΡΠ°Π²Π»ΡΡΡΠ΅Π³ΠΎ Π°Π³Π΅Π½ΡΠ°, ΡΠ°ΠΊ ΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ². Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠΎΠ½ΡΠΎΠΊΠ°Π»ΡΠ½ΠΎΠΉ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ ΠΈ Π½Π°ΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΠΊΡΠΈΠ½Ρ Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΡΡΡΡΡ Π² ΡΠ°Π·Π½ΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠ°ΡΡΠΌΠ΅Π½ΡΠ°Ρ .
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π²Π΅Π΄Π΅ΡΡΡ Π°ΠΊΡΠΈΠ²Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π½ΠΎΠ²ΡΡ ΡΠΈΡΡΠ΅ΠΌ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π³Π΅Π½ΡΠΎΠ² ΠΊ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ-ΠΌΠΈΡΠ΅Π½ΡΠΌ ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² Π·Π° ΡΡΠ΅Ρ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Ρ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΈΡΡΡΡΠΈΠΌΠΈ Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌΠΈ ΠΈΠ»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½Π°ΠΌΠΈ Ρ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΠΎΠΉ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΡΡΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΌΠ½ΠΎΠ³ΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΈΡ in vivo ΠΎΡΡΠ°ΡΡΡΡ ΠΏΠΎΠΊΠ° Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΡΠΌΠΈ.
Π’Π°ΠΊΠΆΠ΅ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ Π½ΠΎΠ²ΡΠ΅ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠΌΡ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΠ΅ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΡΠΈΡΠΈΠ½Ρ ΠΈ Π΅Π³ΠΎ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π-ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅. ΠΠ· ΡΡΠ΅Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΎΠ΄Π½ΠΎ Π±ΡΠ»ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΎ ΠΊ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌΡ ΡΠΏΠΈΡΠΎΠΏΡ Π-ΡΠ΅ΠΏΠΈ ΡΠΈΡΠΈΠ½Π°, ΡΠΊΡΠ°Π½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌΡ Π² ΡΠ΅Π»ΠΎΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠΎΠΊΡΠΈΠ½Π° ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΠΏΡΡ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠ΅ ΡΠ°Π½Π΅Π΅ ΡΡ ΠΎΠ΄ΡΡΠ²ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ ΡΡΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Ρ RTA ΠΈ MLA, Π΄Π°Π½Π½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ Π-ΡΠ΅ΠΏΡΡ ΡΠΈΡΠΈΠ½Π°. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» Π±ΡΠ»Π° ΡΠΎΠ·Π΄Π°Π½Π° ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΠ° Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΡΠΈΡΠΈΠ½Π° Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π΅Π³ΠΎ Π-ΡΠ΅ΠΏΠΈ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π½Π°ΠΏΡΠ°Π²Π»ΡΡΡΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ.
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