ΠΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²Π΅ΠΊΡΠΎΡΠΎΠ² Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ Π² ΠΆΠΈΠ²ΠΎΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π½Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ) Π΄Π»Ρ Π³Π΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Π»Π΅ΠΉ. ΠΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΡΡΠ°ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ) Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠΌ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- ΠΠ»Π°Π²Π° 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ 13 ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΏΡΡΠ΅ΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ — Π³Π΅Π½Π½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ
- 1. 1. ΠΠΈΡΡΡΠ½ΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΠ΅Π»Π΅Π²ΡΡ
Π³Π΅Π½ΠΎΠ²
- 1. 1. 1. ΠΠ΅ΠΊΡΠΎΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅ΡΡΠΎΠ²ΠΈΡΡΡΠΎΠ²
- 1. 1. 2. ΠΠ΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠ½ΡΠ΅ Π²Π΅ΠΊΡΠΎΡΡ
- 1. 1. 3. ΠΠ΄Π΅Π½ΠΎΠ°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π²ΠΈΡΡΡΡ
- 1. 1. 4. ΠΠΈΡΡΡ ΠΏΡΠΎΡΡΠΎΠ³ΠΎ Π³Π΅ΡΠΏΠ΅ΡΠ°
- 1. 1. 5. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π²ΠΈΡΡΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ
- 1. 2. ΠΠ΅Π²ΠΈΡΡΡΠ½ΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°
- 1. 2. 1. ΠΠΈΠΏΠΎΡΠΎΠΌΡ ΠΊΠ°ΠΊ Π²Π΅ΠΊΡΠΎΡΡ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΠΠΠ
- 1. 2. 2. Π Π΅ΡΠ΅ΠΏΡΠΎΡΠ½ΠΎ-ΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΡΠΉ ΡΠΏΠΎΡΠΎΠ± Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ 26 ΠΠΠ-ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ
- 1. 2. 3. ΠΡΠΈΠ½ΡΠΈΠΏΡ ΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌ Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ 33 ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΡΠΌΠΈ ΠΠΠ ΠΏΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΡΠΈΡΠΎΠ·Π°
- 1. 3. ΠΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π»ΠΈΠ³Π°Π½Π΄Π° — Π²Π΅ΠΊΡΠΎΡΠ° Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ 39 1.3.1 Π Π΅ΡΠ΅ΠΏΡΠΎΡΡ Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½Π°
- 1. 4. ΠΠ°Π½ΠΎΡΠ°ΡΡΠΈΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΠΈΠΊΠ°ΡΠΈΠΎΠ½ΠΎΠ² ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
43 Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ²
- 1. 4. 1. Π₯ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ² 43 ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΈ ΠΠΠ-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
- 1. 4. 2. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ Π»ΠΎΠ»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Ρ ΠΈ 50 ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π»ΠΈΠ³Π°Π½Π΄Ρ
- 1. 4. 3. Π€ΠΈΠ·ΠΈΠΊΠΎ-Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ
- 1. 1. ΠΠΈΡΡΡΠ½ΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΠ΅Π»Π΅Π²ΡΡ
Π³Π΅Π½ΠΎΠ²
ΠΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²Π΅ΠΊΡΠΎΡΠΎΠ² Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ Π² ΠΆΠΈΠ²ΠΎΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
ΠΠ΄Π΅Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΏΡΡΠ΅ΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Π½Π΅Π΄ΠΎΡΡΠ°ΡΡΠ΅ΠΉ ΠΈΠ»ΠΈ ΠΈΡΠΏΡΠ°Π²Π»ΡΡΡΠ΅ΠΉ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π±ΡΠ»Π° Π²ΡΠ΄Π²ΠΈΠ½ΡΡΠ° Π² Π½Π°ΡΠ°Π»Π΅ 1970 Π³ΠΎΠ΄ΠΎΠ², Π½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΠ»Π° ΡΠ²ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ·ΠΆΠ΅ (Wolff and Lederberg, 1994; ΠΠΎΡΠ±ΡΠ½ΠΎΠ²Π° ΠΈ ΠΠ°ΡΠ°Π½ΠΎΠ², 1997; Anderson, 1998). ΠΡΠ½ΠΎΠ²Π°Π½Π½ΡΠΉ Π½Π° ΡΡΠΎΠΉ ΠΈΠ΄Π΅Π΅ ΡΠΏΠΎΡΠΎΠ± Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠΈΠ» Π½Π°Π·Π²Π°Π½ΠΈΠ΅ «Π³Π΅Π½Π½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ». ΠΠ΄Π½Π°ΠΊΠΎ, Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° Π²ΠΏΠ΅ΡΠ°ΡΠ»ΡΡΡΠΈΠ΅ ΡΡΠΏΠ΅Ρ ΠΈ Π³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ, Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠ³Π΅Π½ΠΎΠ·Π° ΠΈ ΡΡΠΏΠ΅ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ°Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΌΠ½ΠΎΠ³ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΌΠ΅ΡΠΎΠ΄Ρ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΡΠΆΠ΅ΡΠΎΠ΄Π½ΠΎΠΉ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Π²ΡΠ΅ Π΅ΡΠ΅ ΠΊΡΠ°ΠΉΠ½Π΅ Π½Π΅ΡΠΎΠ²Π΅ΡΡΠ΅Π½Π½Ρ. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² Π΄Π»Ρ ΠΈΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΡ Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΠΏΠΎ ΡΡΠΎΠ²Π½Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ Π΄ΠΎ ΡΠΈΡ ΠΏΠΎΡ ΠΎΡΡΠ°ΡΡΡΡ Π²ΠΈΡΡΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ, ΡΡΡΡ ΠΊΠΎΡΠΎΡΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π°Π±ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π½Π΅ΡΡΡΠΈΡ ΡΠ΅Π»Π΅Π²ΡΠ΅ Π³Π΅Π½Ρ Π²ΠΈΡΡΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅, Π½Π΅ Π²ΡΠ·ΡΠ²Π°Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² Π² ΡΠ΄ΡΠ° ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. Π ΡΠΎΠΆΠ°Π»Π΅Π½ΠΈΡ, ΡΠ΅Π»ΡΠΉ ΡΡΠ΄ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ (Hacein-Bey-Abina et al., 2003; Baum et al., 2006; McElvaney and Crystal, 1995; Raper et al., 2003; Muruve, 2004) Π²ΡΠ΅ Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅Ρ ΠΌΠ½Π΅Π½ΠΈΠ΅ ΠΎ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΈΠ·ΡΡΠΊΠ°Π½ΠΈΡ Π±ΠΎΠ»Π΅Π΅ ΡΠΎΠ²Π΅ΡΡΠ΅Π½Π½ΡΡ ΠΈ Π±Π΅Π·Π²ΡΠ΅Π΄Π½ΡΡ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² Π΄Π»Ρ Π³Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· Π³Π»Π°Π²Π½ΡΡ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ² Π²ΠΈΡΡΡΠ½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±Π°ΠΌ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ Π² ΡΠ²ΠΎΠ΅ΠΉ ΡΡΡΡΠΊΡΡΡΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ ΡΠ΅Π»Π΅Π²ΡΠ΅ Π³Π΅Π½Ρ. ΠΠ»Π°Π·ΠΌ ΠΈΠ΄Ρ ΠΈΠΌΠ΅ΡΡ ΡΠ΅Π»ΡΠΉ ΡΡΠ΄ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ² ΠΏΠ΅ΡΠ΅Π΄ Π²ΠΈΡΡΡΠ°ΠΌΠΈ ΠΈ, ΠΊΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π² Π²ΠΈΠ΄Π΅ ΠΎΡΠΈΡΠ΅Π½Π½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΠΠ. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΡΠ΄Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ Π·Π°ΠΊΠ»ΡΡΠ°ΡΡΡΡ Π² Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ρ ΡΠ΅Π»ΡΠΌ ΡΡΠ΄ΠΎΠΌ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ, ΡΠ΅Π»Π΅Π²ΡΡ Π΄ΠΎΡΡΠ°Π²ΠΊΡ, ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡ ΡΠ΅ΡΠ΅Π· ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΈ ΡΠ΅ΡΠ΅Π· ΡΠ΄Π΅ΡΠ½ΡΠ΅ Π±Π°ΡΡΠ΅ΡΡ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΏΠΎΠΏΡΡΠΊΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π²ΡΠ΅ Π΅ΡΠ΅ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ, ΡΠΈΡΠ»ΠΎ ΡΡΠ°Π½ΡΡΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΠ±ΡΡΠ½ΠΎ Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°Π΅Ρ 10%, ΡΡΠΎ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π΄Π»Ρ ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΊΡΠ°ΠΉΠ½Π΅ Π½ΠΈΠ·ΠΊΠΎ Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΈΡΠΏΡΡΠ°Π½Ρ ΡΠ°Π·Π½ΡΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ, Π½ΠΎ Π² ΡΠ΅Π»ΠΎΠΌ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ (ΠΏΠ» ΠΠΠ) ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ. ΠΠΎΡΡΠΎΠΌΡ ΠΈΠ·ΡΡΠΊΠ°Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ ΠΏΡΡΠ΅ΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π² ΠΊΠ»Π΅ΡΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ Π²Π΅ΡΡΠΌΠ° Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠΈΡΡΠ΅ΠΌΡ: ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ½Π°Π»ΠΈΠ·ΡΡΡΠΈΠΉ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΉ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ»ΠΈΠ³Π°Π½Π΄, ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Ρ ΡΠ΅Π»Π΅Π²ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ΠΎΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π½Π΅Π΅ Π½Π΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΠΎΠΉ Π²Π΅ΠΊΡΠΎΡΠ½ΠΎΠΉ ΠΏΠ°ΡΡ ΠΈ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π½Π°ΡΡΠΎΡΡΠ°Ρ ΡΠ°Π±ΠΎΡΠ°. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π»ΠΈΠ³Π°Π½Π΄Π° Π½Π°ΠΌΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΡΠΉ Π³ΠΎΡΠΌΠΎΠ½ — Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ (ΠΠ), ΠΊΠΎΡΠΎΡΡΠΉ, ΠΏΠΎ ΠΊΡΠ°ΠΉΠ½Π΅ΠΉ ΠΌΠ΅ΡΠ΅, ΡΠ°ΡΡΠΈΡΠ½ΠΎ ΠΏΠΎΡΡΡΠΏΠ°Π΅Ρ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΡΡΠ΅ΠΌ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΌ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠΌ ΠΈ Π΄Π°Π»Π΅Π΅ Π΄ΠΎΡΡΠΈΠ³Π°Π΅Ρ Π²Π½ΡΡΡΠΈΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π°.
ΠΠ° ΠΈΡΠ»Ρ 2007 Π³ΠΎΠ΄Π° ΠΈΠΌΠ΅Π»ΠΈΡΡ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎ 1340 Π·Π°ΠΊΠΎΠ½ΡΠ΅Π½Π½ΡΡ , ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°ΡΡΠΈΡ ΡΡ ΠΈ ΠΎΠ΄ΠΎΠ±ΡΠ΅Π½Π½ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΠΏΡΡΠ°Π½ΠΈΡΡ «Π³Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ» Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΎΠ±Π»Π°ΡΡΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ (Edelstein et al., 2007). Π‘Π»Π΅Π΄ΡΠ΅Ρ ΡΡΠ°Π·Ρ ΠΆΠ΅ ΠΎΠ³ΠΎΠ²ΠΎΡΠΈΡΡΡΡ, ΡΡΠΎ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ², ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ Π½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π²ΠΈΡΡΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅, ΠΊΠ°ΠΊ Π±ΡΠ΄Π΅Ρ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½ΠΈΠΆΠ΅, Π½Π΅ Π»ΠΈΡΠ΅Π½Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ². ΠΠ΄Π½Π°ΠΊΠΎ, Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π±ΠΎΠ»ΡΡΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠΎΠ², Π΄ΠΎ ΡΠΈΡ ΠΏΠΎΡ ΠΊΡΡΠΏΠ½ΡΡ ΡΡΠΏΠ΅Ρ ΠΎΠ² Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π³Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½Π΅ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠΎ. Π ΡΡΠΎΠΌ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΡΠΎΠ²ΠΈ, ΡΠΎΡΠ½Π΅Π΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ. Π‘Π²ΡΠ·Π°Π½ΠΎ ΡΡΠΎ Π² ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ Ρ ΡΠ΅ΠΌ, ΡΡΠΎ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΈΠ»ΠΈ ΠΈΡ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π»Π΅Π³ΠΊΠΎ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ Π²Π½Π΅ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΡΠΈ ΡΡΠΎΠΌ ΡΡΠ°Π·Ρ ΠΏΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΎΡΠ±ΠΎΡΠ° ΠΊΠ»ΠΎΠ½ΠΎΠ² Ρ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ. ΠΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ ΠΌΠΎΠΆΠ΅Ρ ΡΡΡΡΠ°Π½ΠΈΡΡ Π΄Π΅ΡΠ΅ΠΊΡ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΡΠ°ΠΊΠΎΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ ΠΏΡΠΈΠ΅ΠΌΠ»Π΅ΠΌ Π΄Π»Ρ ΠΈΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠΎΠ² (Garcia et al., 2007). ΠΠ΄ΠΈΠ½ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΏΡΠΎΠ΄ΡΠΊΡΠ°ΠΌ Π³Π΅Π½ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ»Π°Π·ΠΌΠΈΠ΄Π½ΡΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΊΡΠΎΠ²ΠΈ Π²ΡΠ³ΠΎΠ΄Π½Π΅Π΅, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π²ΠΈΡΡΡΠ½ΡΠ΅ ΠΏΡΡΠΈ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΠ΅Π»Π΅Π²ΡΡ Π³Π΅Π½ΠΎΠ² ΠΌΠΎΠ³ΡΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ ΠΊ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΏΡΠΎΡΠΎΠΎΠ½ΠΊΠΎΠ³Π΅Π½ΠΎΠ². Π’Π°ΠΊ, Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠ΅ΡΡΠΎΠ²ΠΈΡΡΡΠ½ΡΠΌΠΈ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡΠΌΠΈ ΡΡΠΆΠ΅Π»ΡΡ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠΎΠ² (Pike-Overzet et al., 2007). ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΡΠ»ΡΡΠ°Π΅Π² Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΎΡΡΡΠΎΠΉ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠΉ Π»Π΅ΠΉΠΊΠ΅ΠΌΠΈΠΈ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΠΎ, ΡΡΠΎ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Π²ΡΠ΅ Π±ΠΎΠ»ΡΡΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠΌ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ², ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ°ΠΌ Π³Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π²Π΅Π»ΠΈΠΊ. ΠΠ΅Π»ΠΎ Π΄ΠΎΡ ΠΎΠ΄ΠΈΡ Π΄ΠΎ ΠΊΡΡΡΠ΅Π·ΠΎΠ². ΠΠ°ΠΏΡΠΈΠΌΠ΅Ρ, ΠΏΠΎΡΠ²ΠΈΠ»ΠΈΡΡ ΡΠΎΠΎΠ±ΡΠ΅Π½ΠΈΡ ΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄ΠΎΠΏΠΈΠ½Π³Π° (Gaffney and Parisotto, 2007).
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³Π»ΠΈ Π±Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π²Π΅ΠΊΡΠΎΡΠΎΠ² Π΄Π»Ρ Π³Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ in vivo.
ΠΠ°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
1. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½Π° (ΠΠ) ΠΈ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ².
2. ΠΠΎΠ»ΡΡΠΈΡΡ Π² ΠΎΡΠΈΡΠ΅Π½Π½ΠΎΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ ΠΠ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠ»ΠΈΠ·ΠΈΠ½Π° (ΠΠ), ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ΠΈΠΌΠΈΠ½Π° (ΠΠΠ) ΠΈ Π±Π΅Π»ΠΊΠ° ΠΏΡΠΎΡΠ°ΠΌΠΈΠ½Π° (ΠΠ’).
3. ΠΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Π»ΠΈΠ³Π°Π½Π΄ΠΎΠΌ.
4. ΠΠ·ΡΡΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Ρ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΡΠΌΠΈ ΠΠΠ (ΠΏΠ» ΠΠΠ).
5. ΠΠΎΠ»ΡΡΠΈΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² Ρ ΠΠΠ (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΡ), ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΡΡΠΈΠ΅ ΠΏΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΠΌ Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ.
6. ΠΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡ ΠΏΠ» ΠΠΠ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ².
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΠ, ΠΠΠ ΠΈ ΠΠ’, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π»ΠΈΠ³Π°Π½Π΄Π° ΠΠ, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΏΠΎΡΠΎΠ±Π΅Π½ ΠΏΡΡΠ΅ΠΌ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ½Π΄ΠΎΡΠΈΡΠΎΠ·Π° ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡ Π² ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈ Π΄Π°Π»Π΅Π΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²Π°ΡΡΡΡ ΡΠ΅ΡΠ΅Π· ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠ΅ Π±Π°ΡΡΠ΅ΡΡ Π² ΡΠ΄ΡΠ°. ΠΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΠ» ΠΠΠ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Π²Π΅ΠΊΡΠΎΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΠΠ. ΠΠ°ΠΉΠ΄Π΅Π½ΠΎ, ΡΡΠΎ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΡ) ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΏΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΠΠ, ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² ΠΈ Π±Π΅Π»ΠΊΠ° Π»Π°ΠΊΡΠΎΡΠ΅ΡΡΠΈΠ½Π° (ΠΠ€). ΠΡΡΠ²Π»Π΅Π½Π° ΡΡΠ°Π½ΡΡΠ΅ΡΠΈΡΡΡΡΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΏΡΠΈ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π½Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ) Π΄Π»Ρ Π³Π΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Π»Π΅ΠΉ.
ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ, Π²ΡΠ½ΠΎΡΠΈΠΌΡΠ΅ Π½Π° Π·Π°ΡΠΈΡΡ.
1. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΠΊΠ°ΠΊ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ , ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ , ΠΊΠ°ΡΠ±ΠΎΠ΄ΠΈΠΈΠΌΠΈΠ΄Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΡ Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠΌ — Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠΌ (ΠΠ).
2. Π‘ΡΠ΅ΠΏΠ΅Π½Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Π»Π΅Π³ΠΊΠΎ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π΅ΡΡΡ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈ.
3. ΠΠ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΡΡ Ρ ΠΏΠ» ΠΠΠ. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Ρ ΠΠΠ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ (Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π°, ΡΠ°Π·ΠΌΠ΅ΡΠΎΠ² ΠΈ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ).
4. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΏΠΎΠ»ΠΈΠ»ΠΈΠ·ΠΈΠ½Π°, ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½ΠΈΠΌΠΈΠ½Π° ΠΈ ΠΏΡΠΎΡΠ°ΠΌΠΈΠ½Π° Ρ ΠΠΠ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°ΡΡΠΈΡ, ΡΠ°Π·ΠΌΠ΅ΡΡ ΠΊΠΎΡΠΎΡΡΡ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠ΅ Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ.
5.
ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ° — Π±Π΅Π»ΠΊΠ° ΠΠ€ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ (ΠΏΠ» ΠΠΠ — ΠΠ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ — ΠΠ€), ΡΠ°Π·ΠΌΠ΅ΡΡ ΠΊΠΎΡΠΎΡΡΡ (ΠΎΠΊΠΎΠ»ΠΎ 30 Π½ΠΌ) ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡΠΌ Π΄Π»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ.
6. Π ΠΎΠΏΡΡΠ°Ρ Π½Π° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π½Π° ΡΡΠ°Π½ΡΡΠ΅ΡΠΈΡΡΡΡΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΏΠ» ΠΠΠ — ΠΠ-ΠΠ’ — ΠΠ€ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΏΡΠΈ ΠΏΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ.
ΠΠΏΡΠΎΠ±Π°ΡΠΈΡ ΡΠ°Π±ΠΎΡΡ.
ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π΄ΠΎΠΊΠ»Π°Π΄ΡΠ²Π°Π»ΠΈΡΡ Π² Π²ΠΈΠ΄Π΅ ΡΡΡΠ½ΡΡ ΠΈ ΡΡΠ΅Π½Π΄ΠΎΠ²ΡΡ ΡΠΎΠΎΠ±ΡΠ΅Π½ΠΈΠΉ Π½Π° ΡΠ»Π΅Π΄ΡΡΡΠΈΡ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡΡ :
— III Π½Π°ΡΡΠ½ΠΎ-ΡΠ΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ Π°ΡΠΏΠΈΡΠ°Π½ΡΠΎΠ² Π‘ΠΠ±ΠΠ’Π (Π’Π£), Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, 2000 Π³.;
— ΠΡΡΠ°Ρ ΠΡΠ΅ΡΠΎΡΡΠΈΠΉΡΠΊΠ°Ρ ΠΌΠ΅Π΄ΠΈΠΊΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ «Π§Π΅Π»ΠΎΠ²Π΅ΠΊ ΠΈ Π΅Π³ΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅», Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³ΡΠΊΠΈΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ, 2002 Π³.;
— ΠΠ°ΡΡΠ½ΠΎ-ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ ΡΡΠ΅Π½ΡΡ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ», Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³ΡΠΊΠ°Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠ°Ρ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡ ΠΏΠΎΡΠ»Π΅Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, 2002 Π³.;
— ΠΠ°ΡΡΠ½ΠΎ-ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ ΡΡΠ΅Π½ΡΡ «ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ», Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³ΡΠΊΠ°Ρ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠ°Ρ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡ ΠΏΠΎΡΠ»Π΅Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, 2008 Π³.
ΠΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ.
ΠΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½ΠΎ ΠΏΡΡΡ ΠΏΠ΅ΡΠ°ΡΠ½ΡΡ ΡΠ°Π±ΠΎΡ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΡ ΠΎΠ΄Π½Ρ ΠΏΠΎΠ»Π½ΠΎΡΠ΅ΠΊΡΡΠΎΠ²ΡΡ ΡΡΠ°ΡΡΡ Π² ΠΆΡΡΠ½Π°Π»Π΅ «ΠΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ», Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅ΡΠ²Π΅ΡΠΎ ΡΠ΅Π·ΠΈΡΠΎΠ² ΡΡΡΠ½ΡΡ ΠΈ ΡΡΠ΅Π½Π΄ΠΎΠ²ΡΡ Π΄ΠΎΠΊΠ»Π°Π΄ΠΎΠ².
ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ°Π±ΠΎΡΡ.
ΠΠ°ΡΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π²Π½Π΅Π΄ΡΠ΅Π½Ρ Π² Π½Π°ΡΡΠ½ΡΠΉ ΠΈ ΡΡΠ΅Π±Π½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡΡ ΠΊΠ°ΡΠ΅Π΄ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΠΠ£ ΠΠΠ «Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³ΡΠΊΠΈΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΡΠΈΡΡΡ (Π’Π΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ)» (Π ΠΎΡΡΠΈΡ, 190 013, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, ΠΠΎΡΠΊΠΎΠ²ΡΠΊΠΈΠΉ ΠΏΡ., 26) — ΠΎΡΠ΄Π΅Π»Π° ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΠΠ£ ΠΠ°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΡΠΈΡΡΡΠ° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ Π ΠΠΠ (Π ΠΎΡΡΠΈΡ, 197 376, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, ΡΠ». ΠΠΊ.ΠΠ°Π²Π»ΠΎΠ²Π°, 12) — ΠΊΠ°ΡΠ΅Π΄ΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ ΠΠΠ£ ΠΠΠ «Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³ΡΠΊΠΈΠΉ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΉ Π£Π½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅Ρ ΠΈΠΌΠ΅Π½ΠΈ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΊΠ° Π. Π. ΠΠ°Π²Π»ΠΎΠ²Π° Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π³Π΅Π½ΡΡΡΠ²Π° ΠΏΠΎ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ ΡΠ°Π½Π΅Π½ΠΈΡ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΌΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ» (Π ΠΎΡΡΠΈΡ, 197 089, Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³, ΡΠ». ΠΡΠ²Π° Π’ΠΎΠ»ΡΡΠΎΠ³ΠΎ, 6/8).
ΠΠΈΡΠ½ΡΠΉ Π²ΠΊΠ»Π°Π΄ Π°Π²ΡΠΎΡΠ° Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.
Π‘ΠΎΠΈΡΠΊΠ°ΡΠ΅Π»Π΅ΠΌ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ: Π°Π½Π°Π»ΠΈΠ· Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΠΎ ΡΠ΅ΠΌΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΠ°ΡΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΈ ΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ° Π΄ΠΎΠΊΠ»Π°Π΄ΠΎΠ² Π½Π° ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡΡ . Π‘ΠΈΠ½ΡΠ΅Π· ΠΠ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅, Π°Π½Π°Π»ΠΈΠ· Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Ρ ΠΏΠ» ΠΠΠ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ° Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΏΠΎ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Π±ΡΠΎΠΌΠΈΡΡΠΎΠ³ΠΎ ΡΡΠΈΠ΄ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² ΠΈ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌΠΈ Π²Π΅ΠΊΡΠΎΡΠ°ΠΌΠΈ in vivo Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ , ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ Π»ΠΈΠ½ΠΈΠΉ Π±ΡΠ»ΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Ρ ΡΠΎΠΈΡΠΊΠ°ΡΠ΅Π»Π΅ΠΌ. ΠΠΈΠ΄ΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΡ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΏΠΎ ΡΠ²Π΅ΡΠΎΡΠ°ΡΡΠ΅ΡΠ½ΠΈΡ Π½Π° Π»Π°Π·Π΅ΡΠ½ΠΎΠΌ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΌ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠ΅ JTKC-03 Π½Π°ΡΡΠ½ΡΠΌ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠΌ ΠΠ½ΡΡΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° Π ΠΠΠ Π. Π. ΠΠ΅ΠΊΡΠ°ΡΠΎΠ²ΡΠΌ.
ΠΠ±ΡΠ΅ΠΌ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ.
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Π° Π½Π° 127 ΡΡΡΠ°Π½ΠΈΡΠ°Ρ ΠΌΠ°ΡΠΈΠ½ΠΎΠΏΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΊΡΡΠ°, ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· ΠΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΡΠ΅ΡΡΡΠ΅Ρ Π³Π»Π°Π², Π²ΡΠ²ΠΎΠ΄ΠΎΠ² ΠΈ ΡΠΏΠΈΡΠΊΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, Π² ΠΊΠΎΡΠΎΡΠΎΠΌ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ 197 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ 7 ΡΠ°Π±ΠΎΡ Π½Π° ΡΡΡΡΠΊΠΎΠΌ ΡΠ·ΡΠΊΠ΅ ΠΈ 190 — Π½Π° ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΡ ΡΠ·ΡΠΊΠ°Ρ . Π Π°Π±ΠΎΡΠ° ΠΈΠ»Π»ΡΡΡΡΠΈΡΠΎΠ²Π°Π½Π° 4 ΡΠ°Π±Π»ΠΈΡΠ°ΠΌΠΈ ΠΈ 18 ΡΠΈΡΡΠ½ΠΊΠ°ΠΌΠΈ.
ΠΡΠ²ΠΎΠ΄Ρ.
1. ΠΠ°ΡΠ±ΠΎΠ΄ΠΈΠΈΠΌΠΈΠ΄Π½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠ»ΠΈΠ·ΠΈΠ½Π°, ΠΏΠΎΠ»ΠΈΡΡΠΈΠΌΠ»Π΅Π½ΠΈΠΌΠΈΠ½Π° ΠΈ ΠΏΡΠΎΡΠ°ΠΌΠΈΠ½Π°, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π»ΠΈΠ³Π°Π½Π΄Π° ΠΎΡΡΠ°ΡΠΊΠΈ Π³Π΅ΠΌΠΈΡΡΠΊΡΠΈΠ½Π°ΡΠ° Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½Π°.
2. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΡ Π² Π²ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ ΠΈ ΠΏΠΎ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡΡΡ Ρ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ Π½Π΅ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΎΡ ΠΈΡΡ ΠΎΠ΄Π½ΡΡ ΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ².
3. ΠΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΈ ΠΠΠ Π² ΡΠΎΡΡΠ°Π²Π΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Π·Π°Π²ΠΈΡΡΡ ΠΎΡ ΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ (Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΠΉ ΡΠΎΡΡΠ°Π², ΡΠ°Π·ΠΌΠ΅ΡΡ, ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ).
4. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΈ ΠΠΠ, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΠΊΡΡΠΏΠ½ΡΠ΅ Π°Π³ΡΠ΅Π³Π°ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π±ΠΎΠ»ΡΡΠΈΠΌΠΈ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΠΌΠΈ, ΡΠ΅ΠΌ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ.
5. ΠΠ°Π½ΠΎΡΠ°ΡΡΠΈΡΡ, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΈΠ· ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ, Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΡΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΏΡΠΎΡΠ°ΠΌΠΈΠ½Π° ΠΈ Π΄ΠΎΠ±Π°Π²ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°Π»Π°ΠΊΡΠΎΡΠ΅ΡΡΠΈΠ½Π°, Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΡΠ°Π·ΠΌΠ΅ΡΠ°ΠΌΠΈ (20 — 40 Π½ΠΌ), Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΡΠΈΠ΅ΠΌΠ»Π΅ΠΌΡΠΌΠΈ Π΄Π»Ρ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠΈ.
6. ΠΠ°ΡΠ΅Π½ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΡΡΠ°ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² (Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ) Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΡΠΌ Π³Π΅Π½ΠΎΠΌ, Π³ΠΈΠ΄ΡΠΎΠΊΠΎΡΡΠΈΠ·ΠΎΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ°ΠΌΠΈΠ½Π° ΠΈ Π»Π°ΠΊΡΠΎΡΠ΅ΡΡΠΈΠ½Π° ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΡΠ°Π½ΡΡΠ΅ΠΊΡΠΈΠ΅ΠΉ ΠΏΠΎ ΠΊΡΠ°ΠΉΠ½Π΅ΠΉ ΠΌΠ΅ΡΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠ΅ΠΊ Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ ΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠ³ΠΎ Π³Π΅Π½Π° (Π±Π΅ΡΠ°-Π³Π°Π»Π°ΠΊΡΠΎΠ·ΠΈΠ΄Π°Π·Ρ).
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