Характеристика ckit позитивных резидентных стволовых клеток миокарда у больных ишемической болезнью сердца

выводы.

1. В миокарде ушка ПП, аневризмы у больных ИБС и в неповрежденном миокарде присутствуют с—кк+ клетки, характеризующиеся экспрессией маркеров стволовых клеток (ШЖ1, С-те!-, ЮБ-Ш, 1Ч-кадгерин) и отсутствием гематопоэтических маркеров (СБ34, СБ45) — количество этих клеток в неповрежденном миокарде обратно коррелирует с возрастом (г — 0,78- р<0,0001).

2. В миокарде ушка ПП больных ИБС и в неповрежденном миокарде часть с-кй+ стволовых клеток сердца пролиферирует и дифференцируется в клетки-предшественники кардиомиоцитов и гладкомышечных клетокв ткани аневризмы ЛЖ с-кй+ клетки не пролиферируют, не экспрессируют маркеров дифференцировки в кардиомиоциты и клетки сосудов и экспрессируют ингибитор клеточного цикла р21 С1рА? аГ1.

3. Количество с-кй+ клеток в миокарде ушка ПП наибольшее у женщин моложе 60 лет, оно положительно коррелирует с выраженностью атеросклероза коронарных артерий и дилатации ЛП, но не зависит от наличия факторов риска сердечно-сосудистых заболеваний (артериальной гипертонии, сахарного диабета, гиперлипидемии, ожирения, курения) и ИМ в анамнезе.

4. Разработанная методика, сочетающая использование метода эксплантной культуры и последующей иммуномагнитной селекции, позволяет получить обогащенную культуру с-кй+ СКС из операционных образцов миокарда человека.

5. Пролиферативный потенциал культивируемых c-kit+ клеток, получаемых из ткани ушка ПП выше, чем у клеток, получаемых из ткани аневризмыкультивируемые c-kit+ клетки ушка ПП обладают клоногенностью и экспрессируют гены плюрипотентности (Oct4, Sox2, Klf4, C-myc, Nanog).

6. Культивируемые c-kit+ клетки ушка ПП могут быть индуцированы к начальным этапам кардиомиоцитарной дифференцировки и к эндотелиальной дифференцировке, способны формировать капилляроподобные структуры in vitro и секретируют ангиогенные факторы роста (VEGF и HGF) — c-kit+ клетки, полученные из аневризмы, способны только к начальным этапам кардиомиоцитарной дифференцировки.

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