ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ
ΠΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π΄Π»Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΈΠ· Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΠΏΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ°. ΠΠ΄Π½Π°ΠΊΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠ΅ ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΡΡΠ½ΡΠΌ. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΌΠ°Π»ΠΎ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎ ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΌ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ². Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π½Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΡΠ΅ Π΄Π»Ρ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΡΡΠΊΡΡΡΡ ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ²
- ΠΠ»Π°Π²Π° 1. Π’ΠΈΠΏΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΡΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡ
- ΠΠ»Π°Π²Π° 2. ΠΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ² Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ²
- 2. 1. ΠΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ
- 2. 2. Π’ΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 2. 3. Π’ΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ
- ΠΠ»Π°Π²Π° 3. ΠΡΠΎΡΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ² Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ²
- 3. 1. ΠΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ
- 3. 2. Π’ΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΡΡΠΊΠ°ΡΠΈΠΎΡΠΎΠ²
- 3. 3. ΠΠ°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΡ
- ΠΠ»Π°Π²Π° 4. ΠΠΊΡΠΈΠ²Π½ΡΠΉ ΡΠ΅Π½ΡΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ
ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ²
- 4. 1. ΠΠΊΡΠΈΠ²Π½ΡΠΉ ΡΠ΅Π½ΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°: Π‘ΡΠΊΡΠΈΠ½Π°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Π°
- 4. 2. Π§Π΅ΡΠ²Π΅ΡΡΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ²
- 4. 3. Π’ΠΎΡΠΊΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² Π² ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ°Ρ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ²
- 4. 4. ΠΠ°Π½Π°Π» Π² Π°ΠΊΡΠΈΠ²Π½ΠΎΠΌ ΡΠ΅Π½ΡΡΠ΅ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ²
- — 4.5. ΠΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ² Π² ΠΈΠ½ΡΠ΅ΡΡΠ°Π·Π΅
- ΠΠ»Π°Π²Π° 5. ΠΠΎΠ΄Π΅Π»ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ
ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ²
- 5. 1. Π’ΠΈΠΏΡ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π²ΡΠΈΡ ΡΡ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ
- 5. 2. ΠΠΎΠ΄Π΅Π»Ρ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠ° Ρ ΠΈΠ·ΠΌΠ΅Π½ΡΡΡΠΈΠΌΡΡ ΠΊΠ°Π½Π°Π»ΠΎΠΌ
- 5. 3. ΠΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΡΠΎΡΠ΅ΠΊ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠ° Π² ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ΅
- ΠΠΠΠΠ§Π ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ―
- ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠΠ― Π§ΠΠ‘Π’
- ΠΠ»Π°Π²Π° 6. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 6. 1. Π‘ΡΠ΅Π΄Ρ
- 6. 2. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ
- 6. 3. ΠΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ° Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ S. cerevisiae
- 6. 4. ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΊΠΎΡΠΎΡΡΠ΅ΠΉ Π΄ΡΡ Π°Π½ΠΈΡ
- 6. 5. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ±ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ ΡΠ°ΡΡΠΈΡ
- 6. 6. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΡΠ°Π²Π° ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΡΠ±ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ ΡΠ°ΡΡΠΈΡ
- 6. 7. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΈ Π΄ΠΎΡΡΡΠΏΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΠΎΠΉ ΡΠ°Π·Ρ ΠΊΠ»Π΅ΡΠΎΠΊ
- 6. 8. ΠΡΡΠ³ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 6. 9. Π Π΅Π°ΠΊΡΠΈΠ²Ρ ΠΈ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ
- 6. 10. Π Π°ΡΡΠ΅ΡΡ
- ΠΠ»Π°Π²Π° 7. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 7. 1. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠΎΠΏΡΡΠΆΠ΅Π½Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌ
- 7. 2. ΠΠΎΠ½Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° ΡΡΠΊΡΠΈΠ½Π°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ
- 7. 3. ΠΠΎΠ½Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ
- 7. 4. ΠΠΎΠ½Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ
- ΠΠ»Π°Π²Π° 8. ΠΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- ΠΠ«ΠΠΠΠ«
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
Π§Π΅ΡΡΡΠ΅Ρ ΡΠ³Π»Π΅ΡΠΎΠ΄Π½ΡΠ΅ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡ (ΠΏΡΠ΅ΠΆΠ΄Π΅ Π²ΡΠ΅Π³ΠΎ L-ΠΌΠ°Π»Π°Ρ ΠΈ ΡΡΠΊΡΠΈΠ½Π°Ρ) ΠΈΠ³ΡΠ°ΡΡ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ΅. ΠΠ½ΠΈ ΡΠ²Π»ΡΡΡΡΡ ΠΈΠ½ΡΠ΅ΡΠΌΠ΅Π΄ΠΈΠ°ΡΠ°ΠΌΠΈ ΡΠΈΡΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π°, Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π² ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΡΡ . ΠΠΊΠΈΡΠ»Π΅Π½ΠΈΠ΅ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ² Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ°Π²ΡΠΈΠΊΠ° ΠΠ’Π€ Π² ΠΊΠ»Π΅ΡΠΊΠ΅.
ΠΠ°ΡΡΠ΄Ρ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ Π² ΠΎΠ±ΠΌΠ΅Π½Π΅ Π²Π΅ΡΠ΅ΡΡΠ² ΠΎΡΠΎΠ±ΡΡ ΡΠΎΠ»Ρ ΠΈΠ³ΡΠ°Π΅Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΠ°Π½ΡΠΏΠΎΡΡ ΡΡΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² ΡΠ΅ΡΠ΅Π· Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ. Π’Π°ΠΊ, Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΡΡΠ°Π½ΡΠΏΠΎΡΡ L-ΠΌΠ°Π»Π°ΡΠ° ΡΠ΅ΡΠ΅Π· ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΡΠ²ΡΠ·Π°Π½ Ρ ΡΠ°ΠΊ Π½Π°Π·ΡΠ²Π°Π΅ΠΌΡΠΌ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΎΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΊΠ²ΠΈΠ²Π°Π»Π΅Π½ΡΠΎΠ², Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠΌ Π΄Π»Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ Π΄Π²ΡΠΌΡ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΏΡΠ»Π°ΠΌΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½Π°ΠΌΠΈΠ΄Π°Π΄Π΅Π½ΠΈΠ½Π΄ΠΈΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄ΠΎΠ² — ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΈ ΡΠΈΡΠΎΠ·ΠΎΠ»ΡΠ½ΡΠΌ. Π’ΡΠ°Π½ΡΠΏΠΎΡΡ ΡΡΠΊΡΠΈΠ½Π°ΡΠ° ΡΠ΅ΡΠ΅Π· ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ±ΠΌΠ΅Π½ΠΎΠΌ Π² ΠΏΠ΅ΡΠΎΠΊΡΠΈΡΠΎΠΌΠ°Ρ ΠΈ ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΡΡ .
ΠΡΠΎΠ±ΡΡ ΡΠΎΠ»Ρ ΠΈΠ³ΡΠ°Π΅Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡ L-ΠΌΠ°Π»Π°ΡΠ° ΡΠ΅ΡΠ΅Π· ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΊΠ»Π΅ΡΠΊΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΡΠΎΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°Ρ, Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π΅Π³ΠΎ ΠΎΡΠΎΠ±ΠΎΠΉ ΡΠΎΠ»ΠΈ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ ΠΎΠ±ΠΌΠ΅Π½Π΅ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠΌ ΡΠ³Π»Π΅ΡΠΎΠ΄Π°, Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π΄Π»Ρ ΡΠΎΡΡΠ° Π² Π°ΡΡΠΎΠ±Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΠΊΠ°ΡΠΈΠΎΡΠΎΠ². ΠΠ° Π²Π°ΠΆΠ½ΠΎΡΡΡ ΡΡΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΡΠΎ, ΡΡΠΎ Ρ ΡΡΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΈΡΠΉ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅Ρ ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅ΡΡΡ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π² ΡΡΠ΅Π΄Π΅ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ L-ΠΌΠ°Π»Π°ΡΠ°. ΠΠ°Π΄ΠΎ ΠΎΡΠΌΠ΅ΡΠΈΡΡ, ΡΡΠΎ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΈΡΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊ Π±ΡΠ» ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΡΠΎΡΡ ΠΊΠΎΡΠΎΡΡΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡ Π½Π΅ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡ. Π₯ΠΎΡΡ ΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΡ ΠΌΠΎΠ³ΡΡ Π°ΡΡΠΈΠΌΠΈΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΎ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π΄ΡΡΠ³ΠΈΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² ΡΠ³Π»Π΅ΡΠΎΠ΄Π°, ΡΡΠ½ΠΊΡΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠ° Π² ΡΡΠΎΠΌ ΡΠ»ΡΡΠ°Π΅ Π½Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π°.
ΠΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΠΉ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅Ρ ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ ΠΎΡΠΎΠ±ΠΎΠΌΡ ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎΠΌΡ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Ρ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΡΡΠΊΡΡΡΠ½ΠΎ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΎΡ Π΄ΡΡΠ³ΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΡΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. Π‘ΡΡΡΠΊΡΡΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ² ΠΎΡΡΠ°ΠΆΠ°ΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΡ ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π’Π°ΠΊ, ΡΡΠ°Π½ΡΠΏΠΎΡΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ² Π½Π΅ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠ°ΠΌΠΈ ΡΠΎΠΏΡΡΠΆΠ΅Π½ Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΎΠΌ ΠΊΠ°ΡΠΈΠΎΠ½ΠΎΠ². ΠΡΡΡ Π³ΡΡΠΏΠΏΠ° ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ², ΠΊΠΎΡΠΎΡΠ°Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠ°ΡΠΈΠΎΠ½ΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅Ρ ΠΈΠΎΠ½Ρ Π½Π°ΡΡΠΈΡ. ΠΡΡΠ³Π°Ρ Π³ΡΡΠΏΠΏΠ° ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΡ Π² ΡΠΈΠΌΠΏΠΎΡΡΠ΅ Ρ ΠΏΡΠΎΡΠΎΠ½Π°ΠΌΠΈ. ΠΡΠ° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ² ΠΎΡ ΠΊΠ°ΡΠΈΠΎΠ½ΠΎΠ², ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΡΠ²ΡΠ·Π°Π½Π° Ρ ΡΠ΅ΠΌ, ΡΡΠΎ ΡΡΠΎΡ ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΡΡΡ Π±ΠΠ’Π€Π°Π·Π°ΠΌΠΈ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ, Ρ. Π΅. Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΠ»Π΅ΡΠΊΠΈ.
ΠΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π΄Π»Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΈΠ· Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΠΏΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ°. ΠΠ΄Π½Π°ΠΊΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠ΅ ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΡΡΠ½ΡΠΌ. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΌΠ°Π»ΠΎ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎ ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΌ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ². Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π½Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΡΠ΅ Π΄Π»Ρ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΠΈΠΊΠΎΠ² ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΡΡΠΊΡΡΡΡ ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ°, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠΎΡΠΊΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠΎΠ² ΠΈ ΠΊΠ°Π½Π°Π»Ρ, ΠΏΠΎ ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΠΎΡΡΡΠΏΠ°ΡΡ ΡΡΠ±ΡΡΡΠ°ΡΡ ΠΊ ΡΡΠΈΠΌ ΡΠΎΡΠΊΠ°ΠΌ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ.
ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ .
Π‘Π’Π Π£ΠΠ’Π£Π Π Π ΠΠ ΠΠΠΠΠΠΠΠΠΠΠ«Π ΠΠΠ₯ΠΠΠΠΠΠ« Π€Π£ΠΠΠ¦ΠΠΠΠΠ ΠΠΠΠΠΠ― ΠΠΠΠΠ ΠΠΠΠ‘ΠΠΠΠ’ΠΠ«Π₯ ΠΠΠ ΠΠΠΠ‘Π§ΠΠΠΠ.
Π²ΡΠ²ΠΎΠ΄Ρ.
1. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π·ΠΎΠ½Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ² ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ ΠΈ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ ΠΊΠ»Π΅ΡΠΎΠΊ S. cerevisiae Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π½Π°Π±ΠΎΡΠ° Π°Π»ΠΊΠΈΠ»ΠΈ Π°ΡΠΈΠ»-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ ΠΌΠ°Π½Π°ΡΠ° ΠΈ ΠΌΠ°Π»ΠΎΠ½Π°ΡΠ°.
2. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² Π°ΠΊΡΠΈΠ²Π½ΠΎΠΌ ΡΠ΅Π½ΡΡΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΠΉ ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡ Π±ΠΎΠ»ΡΡΠΎΠΉ ΠΈ ΠΌΠ°Π»ΡΠΉ Π»ΠΈΠΏΠΎΡΠΈΠ»ΡΠ½ΡΠ΅ Π΄ΠΎΠΌΠ΅Π½Ρ, ΡΠ°Π·Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΡΡΠ½ΡΠΌ ΡΡΠ°ΡΡΠΊΠΎΠΌ. ΠΠΎ Π²Π½Π΅ΡΠ½Π΅ΠΌ ΠΏΠΎΠ»ΡΠΊΠ°Π½Π°Π»Π΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΏΡΠΈΡΡΡΡΡΠ²ΡΠ΅Ρ ΡΠΎΠ»ΡΠΊΠΎ ΠΎΠ΄Π½Π° ΡΠΎΡΠΊΠ° ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ², Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΎΡΡΡΡΡΡΠ²ΡΡΡ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΠΈΡ Π΄Π»Ρ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ»ΡΠ½Π°Ρ Π³ΡΡΠΏΠΏΠ° L-ΠΌΠ°Π»Π°ΡΠ° ΡΡΠ°ΡΡΠ²ΡΠ΅Ρ Π² ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΡΡΠΎΠ³ΠΎ ΡΡΠ±ΡΡΡΠ°ΡΠ° Π² ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ΅.
3. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠΊΡΠΈΠ½Π°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Π΅ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ ΠΎΠ±Π»Π°ΡΡΡ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠ° ΠΈΠΌΠ΅Π΅Ρ ΡΠ°Π·ΠΌΠ΅ΡΡ, ΡΠΎΠ·Π΄Π°ΡΡΠΈΠ΅ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΠΈΡ Π΄Π»Ρ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ² ΡΡΠ±ΡΡΡΠ°ΡΠ°. ΠΠ΄Π½Π°ΠΊΠΎ Π²Π±Π»ΠΈΠ·ΠΈ ΡΡΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π½Π°Ρ ΠΎΠ΄ΠΈΡΡΡ ΠΏΡΠΎΡΡΠΎΡΠ½ΡΠΉ Π»ΠΈΠΏΠΎΡΠΈΠ»ΡΠ½ΠΎ-Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΠΉ ΡΡΠ°ΡΡΠΎΠΊ.
4. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ Π² Π°ΠΊΡΠΈΠ²Π½ΠΎΠΌ ΡΠ΅Π½ΡΡΠ΅ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΡΡΡΡΡΠ²ΡΠ΅Ρ Π±ΠΎΠ»ΡΡΠΎΠΉ Π»ΠΈΠΏΠΎΡΠΈΠ»ΡΠ½ΡΠΉ Π΄ΠΎΠΌΠ΅Π½, ΠΊΠΎΡΠΎΡΡΠΉ, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠ².
5. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΡΠΎΠ½ΠΈΡΠ°Π΅ΠΌΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ S. cerevisiae Π΄Π»Ρ Π°ΠΌΡΠΈΡΠΈΠ»ΡΠ½ΡΡ ΠΊΠΈΡΠ»ΠΎΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π-Π°ΡΠΈΠ»^-ΠΌΠ°Π»Π°ΡΡ Π½Π΅ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡ Π² ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈ ΠΏΠΎΡΡΠΎΠΌΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ Ρ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΡΠΌ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠΎΠΌ ΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ.
6. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΡΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ Π²Π°ΠΆΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΡΡΠΊΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ΅ΡΠ°.
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- ΠΡΡΠ°ΠΆΠ°Ρ ΠΈΡΠΊΡΠ΅Π½Π½ΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ ΠΌΠΎΠ΅ΠΌΡ Π½Π°ΡΡΠ½ΠΎΠΌΡ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π½Π°ΡΠΊ ΠΡΠΈΡΡΠΎΡΠΎΡΡ Π€ΡΠ°Π½ΡΠ΅Π²ΠΈΡΡ Π¨ΠΎΠ»ΡΡΡ Π·Π° ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈΠ΄Π΅ΠΈ, Π΄ΠΎΡΠΎΡΠ½ΠΎΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² ΠΈ ΠΏΠΎΠΌΠΎΡΡ Π² ΠΎΠ²Π»Π°Π΄Π΅Π½ΠΈΠΈ Π½ΠΎΠ²ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ.
- Π― ΡΠ°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π½Π°ΡΠΊ ΠΠΌΠΈΡΡΠΈΡ ΠΠΎΡΠΈΡΠΎΠ²ΠΈΡΡ ΠΠΎΠ½Π΄Π°ΡΠ΅Π½ΠΊΠΎ Π·Π° ΡΠΈΠ½ΡΠ΅Π· ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π½Π°ΡΠΊ ΠΠΈΠ½Π°ΡΠ΅ ΠΠ»ΠΈΠ΅Π²Π½Π΅ ΠΠ»ΠΈΠ²Π΅ΡΠ΄ΠΈΠ΅Π²ΠΎΠΉ Π·Π° ΠΏΠΎΠΌΠΎΡΡ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠΈΡΠΎΡ ΠΎΠ½Π΄ΡΠΈΡΠΌΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ.
- Π― ΠΎΡΠ΅Π½Ρ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ Π²ΡΠ΅ΠΌΡ ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Ρ ΠΠ°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ ΠΠ½ΡΡΠΈΡΡΡΠ° Π±ΠΈΠΎΡ ΠΈΠΌΠΈΠΈ Π ΠΠ Π·Π° ΠΌΠΎΡΠ°Π»ΡΠ½ΡΡ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ, ΠΊΠΎΠ½ΡΡΠ»ΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠΌΠΎΡΡ ΠΈ ΠΏΠΎΠ»Π΅Π·Π½ΡΠ΅ ΡΠΎΠ²Π΅ΡΡ.