Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70 Ρ Π²ΠΈΠ΄ΠΎΠ² Dropsophila Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠ΅ΠΉ
ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ Π³Π΅Π½ΠΎΠ² hsp70 ΠΈ ΠΏΠ°ΡΡΠ΅ΡΠ½Π° ΠΠ’Π¨70 D. virilis ΠΈ D. lummei Ρ Π΄Π°Π½Π½ΡΠΌΠΈ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌΠΈ Π΄Π»Ρ Π΄ΡΡΠ³ΠΈΡ Π²ΠΈΠ΄ΠΎΠ² Diptera, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅Π΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70 Π² Π΄Π°Π½Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΈ ΠΈΡ ΡΡΠ°ΡΡΠΈΠ΅ Π² ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°ΡΡ Π³Π΅Π½Ρ hsp70 D. virilis ΠΈ D. lummei, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΈΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΎΠ±ΡΡΡ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ»Π°ΡΡΠ΅ΡΠ° ΠΈ ΡΠΈΡΠ»ΠΎ ΠΊΠΎΠΏΠΈΠΉ Π³Π΅Π½ΠΎΠ² hsp70 D… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- 1. 1. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠΊΠ°: ΠΎΠ±ΡΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ
- 1. 2. ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΠ’Π¨
- 1. 3. Π Π΅Π³ΡΠ»ΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π’Π¨
- 1. 4. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² Π°ΠΏΠΏΠ°ΡΠ°ΡΠ΅ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΠΈ ΡΡΠ°Π½ΡΠ»ΡΡΠΈΠΈ ΠΏΡΠΈ Π’Π¨
- 1. 5. Π€ΡΠ½ΠΊΡΠΈΠΈ ΠΠ’Π¨ Π² Π°ΠΏΠΎΠΏΡΠΎΠ·Π΅
- 1. 6. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΠ²ΠΎΠ»ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² Π’Π¨
- 1. 7. ΠΠ’Π¨ Π² Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌ ΡΡΠ΅Π΄Ρ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ
- 1. 8. ΠΠ’Π¨ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅ ΠΈ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ
- 2. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ 51 2.1.1 ΠΠΈΠ½ΠΈΠΈ ΠΈ Π²ΠΈΠ΄Ρ ΠΠ³ΠΎΠΠΎΡΠΠΠ°
- 2. 1. 2. Π¨ΡΠ°ΠΌΠΌΡ Π. ΡΠΎΠ
- 2. 1. 3. ΠΠ»ΠΎΠ½Ρ /75Ρ70 Π. melanogaster
- 2. 1. 4. Π€Π΅ΡΠΌΠ΅Π½ΡΡ ΡΠ΅ΡΡΡΠΈΠΊΡΠΈΠΈ
- 2. 1. 5. ΠΠ»ΠΈΠ³ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Ρ Π΄Π»Ρ Π°Π½Π°Π»ΠΈΠ·Π° ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Ρ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ Π’Π¨
- 2. 1. 7. ΠΠ½ΡΠΈΡΠ΅Π»Π°
- 2. 2. ΠΠ΅ΡΠΎΠ΄Ρ
- 2. 2. 1. Π£ΡΠ»ΠΎΠ²ΠΈΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»
- 2. 2. 2. Π£ΡΠ»ΠΎΠ²ΠΈΡ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠΊΠ°
- 2. 2. 3. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π±Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΠΈ ΠΈΠ½Π΄ΡΡΠΈΠ±Π΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ
- 2. 2. 4. ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΈΠΎΠ½ΠΈΠ½Π° -358 Π² Π±Π΅Π»ΠΊΠΈ
- 2. 2. 5. ΠΠΎΠ΄ΡΡΡΡ ΠΎΠ±ΡΠ΅Π³ΠΎ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠΈΠΎΠ½ΠΈΠ½Π°- 8 Π² Π±Π΅Π»ΠΊΠΈ
- 2. 2. 6. ΠΠΈΡΠΊ-ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π±Π΅Π»ΠΊΠΎΠ² Ρ ΠΠ¦Π‘-ΠΠ° (ΠΏΠΎ ΠΡΠΌΠΌΠ»ΠΈ)
- 2. 2. 7. ΠΠ²ΡΠΌΠ΅ΡΠ½ΡΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π±Π΅Π»ΠΊΠΎΠ² ΠΏΠΎ Π’Π€Π°ΡΡΠ΅Π»Π»Ρ
- 2. 2. 8. ΠΠΌΠΌΡΠ½ΠΎΠ±Π»ΠΎΡΡΠΈΠ½Π³
- 2. 2. 9. ΠΠΌΠΌΡΠ½ΠΎΠΏΡΠ΅ΡΠΈΠΏΠΈΡΠ°ΡΠΈΡ
- 2. 2. 10. ΠΡΠΈΡΡΠΊΠ° Π±Π΅Π»ΠΊΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·Π°
- 2. 2. 11. ΠΠ±ΡΠ°Π±ΠΎΡΠΊΠ° Π±Π΅Π»ΠΊΠ° ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΡΡΠΈΠΏΡΠΈΠ½ΠΎΠΌ Π΄Π»Ρ ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ ΠΊΠ°ΡΡ
- 2. 2. 12. ΠΠ½Π°Π»ΠΈΠ· ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Ρ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ°ΠΌΠΈ Π’Π¨
- 2. 2. 13. ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠ΅ΡΠΊΠΈ Π² ΠΠΠ
- 2. 2. 14. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠΌΠ½ΠΎΠΉ ΠΠΠ
- 2. 2. 15. Π Π°ΡΡΠ΅ΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΠΠ ΡΠ΅ΡΡΡΠΈΡΠΈΡΡΡΡΠΈΠΌΠΈ ΡΠ½Π΄ΠΎΠ½ΡΠΊΠ»Π΅Π°Π·Π°ΠΌΠΈ
- 2. 2. 16. ΠΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· ΠΠΠ
- 2. 2. 17. ΠΠ΅ΡΠ΅Π½ΠΎΡ ΠΈ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎ Π‘Π°ΡΠ·Π΅ΡΠ½Ρ
- 2. 2. 18. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° ΠΊΠΎΠΏΠΈΠΉ Π³Π΅Π½Π° ΠΏΠΎ Π‘Π°ΡΠ·Π΅ΡΠ½Ρ
- 2. 2. 19. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ Π ΠΠ
- 2. 2. 20. ΠΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π ΠΠ
- 2. 2. 21. ΠΠΎΠ·Π΅ΡΠ½-Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΡ
- 2. 2. 22. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠΌΠ½ΡΡ ΡΠ°Π³ΠΎΠ²ΡΡ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊ
- 2. 2. 23. Π‘ΠΊΡΠΈΠ½ΠΈΠ½Π³ ΡΠ°Π³ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠΌΠ½ΡΡ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊ
- 2. 2. 24. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΠΠ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Π° X
- 2. 2. 25. ΠΠΎΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΡΡΠΈΠΊΡΠ½ΡΡ ΠΊΠ°ΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΠ°Π³ΠΎΠ²
- 2. 2. 26. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ
- 2. 2. 27. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ
- 2. 2. 28. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 2. 2. 29. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 2. 30. Π‘Π΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ 51 2.1.1 ΠΠΈΠ½ΠΈΠΈ ΠΈ Π²ΠΈΠ΄Ρ ΠΠ³ΠΎΠΠΎΡΠΠΠ°
- 3. 1. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π±Π°Π·Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ Ρ Π²ΠΈΠ΄ΠΎΠ² ΠΈ Π»ΠΈΠ½ΠΈΠΉ Π³ΡΡΠΏΠΏΡ Ρ ΡΠ¨
- 3. 2. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ Ρ Π²ΠΈΠ΄ΠΎΠ² ΠΈ Π»ΠΈΠ½ΠΈΠΉ Π³ΡΡΠΏΠΏΡ irilis
- 3. 3. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ ΡΠ΅ΡΠΈΠΏΡΠΎΠΊΠ½ΡΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠ²
- 3. 4. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΠ±ΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΏΡΠΈ Π’Π¨ Ρ ?). irilis ΠΈ Π. 1ΠΈΡΡΠ΅
- 3. 5. ΠΠ°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΠ’Π¨70 ΠΏΡΠΈ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠΌ ΡΠΎΠΊΠ΅
- 3. 6. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΠΌΠ ΠΠ ΠΠ’Π¨
- 3. 7. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ
- 3. 8. ΠΠ½Π°Π»ΠΈΠ· ΠΏΠ°ΡΡΠ΅ΡΠ½Π° ΠΠ’Π¨70 ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏ ΠΠ’Π¨ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄Π²ΡΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·Π°
- 3. 9. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΏΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌ ΠΌΠ°ΡΡΠ°ΠΌ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 10. Π Π΅ΡΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΠΉ ΠΈ Π‘Π°ΡΠ·Π΅ΡΠ½-Π°Π½Π°Π»ΠΈΠ· Π³Π΅Π½ΠΎΠ² Π«Ρ70 Π. irilis
- 3. 11. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° ΠΊΠΎΠΏΠΈΠΉ Π³Π΅Π½Π° 1Π³Π·Ρ70 Ρ ΡΠ°Π·Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ Π. irilis ΠΈ umme
- 3. 12. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ»Π°ΡΡΠ΅ΡΠ° Π³Π΅Π½ΠΎΠ² /ΠΈΡ70 ?>. irilis ΠΈ Π. 1ΠΈΡΡΠ΅1 Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΠ°Π³ΠΎΠ² X
- 3. 13. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΠΎΠΉ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π³Π΅Π½ΠΎΠ² ΠͺΠ·Ρ70 ΠΈ ΠΏΡΠΈΠ»Π΅ΠΆΠ°ΡΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ² 0.1ΠΈΡΡΠ΅1 ΠΈ, Π irilis
Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70 Ρ Π²ΠΈΠ΄ΠΎΠ² Dropsophila Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠ΅ΠΉ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠ»Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌ ΡΡΠ΅Π΄Ρ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ. Π‘ΡΠ΅Π΄ΠΈ ΠΏΡΠΎΡΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΆΠΈΠΌΠ° ΡΠ²Π»ΡΡΡΡΡ ΡΠ°ΠΊΠΆΠ΅ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ΄ΠΎΠ±Π½ΡΠΌ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ. ΠΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π½Π° 5 — 15 Β°C Π²ΡΡΠ΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ (ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠΉ ΡΠΎΠΊ, Π’Π¨) Π²ΡΠ·ΡΠ²Π°Π΅Ρ Ρ Π²ΡΠ΅Ρ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² (ΠΎΡ Π. coli Π΄ΠΎ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°) Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π³ΡΡΠΏΠΏΡ Π³Π΅Π½ΠΎΠ², Π½Π°Π·Π²Π°Π½Π½ΡΡ Π³Π΅Π½Π°ΠΌΠΈ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠΊΠ°. ΠΠ΅Π»ΠΊΠΈ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΡΠΎΠΊΠ° (ΡΠΎΠΊΡΠ°ΡΡΠ½Π½ΠΎ ΠΠ’Π¨ ΠΈΠ»ΠΈ HSP — heat shock proteins) ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΠ΅ΡΡΠΎΠ²ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π²ΡΠΏΠΎΠ»Π½ΡΡΡ Π² ΠΊΠ»Π΅ΡΠΊΠ΅ Π·Π°ΡΠΈΡΠ½ΡΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡ Π΄Π΅Π½Π°ΡΡΡΠ°ΡΠΈΠΈ ΠΈ Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ Π±Π΅Π»ΠΊΠΎΠ². Π‘ΡΠΈΡΠ°Π΅ΡΡΡ, ΡΡΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ Π·Π°ΡΠΈΡΠ½ΡΡ ΡΡΠ½ΠΊΡΠΈΡ Π²ΡΠΏΠΎΠ»Π½ΡΠ΅Ρ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Π±Π΅Π»ΠΊΠΎΠ² ΠΌΠ°ΡΡΠΎΠΉ 70 ΠΊΠΠ° (ΠΠ’Π¨70 ΠΈΠ»ΠΈ HSP70). Π Π°Π±ΠΎΡΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ²ΡΠΈΠ΅ ΡΠ΄Π΅Π»Π°ΡΡ ΡΠ°ΠΊΠΎΠΉ Π²ΡΠ²ΠΎΠ΄, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π½Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅. ΠΠΎΠΏΡΠΎΡ ΠΎΠ± ΡΡΠ°ΡΡΠΈΠΈ ΠΠ’Π¨70 Π² Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠ΅Π»ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΎΡΡΠ°ΡΡΡΡ ΡΠΏΠΎΡΠ½ΡΠΌ. Π‘ ΡΡΠΎΠΉ ΡΠΎΡΠΊΠΈ Π·ΡΠ΅Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΡΠ²ΠΎΠ»ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ², ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΡ Π±Π΅Π»ΠΊΠΈ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΠΠ’Π¨70, ΠΈΡ ΡΡΡΡΠΊΡΡΡΠ° ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Ρ Π±Π»ΠΈΠ·ΠΊΠΎΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΡΠ΅Π·ΠΊΠΎ ΡΠ°Π·Π»ΠΈΡΠ°ΡΡΠΈΡ ΡΡ ΠΏΠΎ ΠΊΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌ ΡΡΠ΅Π΄Ρ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΡ ΡΡ ΡΠ°Π·Π½ΡΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ. Π£Π΄ΠΎΠ±Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π’Π¨ ΡΠ²Π»ΡΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π²ΠΈΠ΄Ρ Drosophila. Π Π°Π½Π΅Π΅ Π³Π΅Π½Ρ Π’Π¨ Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Ρ D. melanogaster. ΠΠ»Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΈ Π²ΡΠ±ΡΠ°Π½Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ Π²ΠΈΠ΄ΠΎΠ² Drosophila, ΠΎΡΠ½ΠΎΡΡΡΠΈΡ ΡΡ ΠΊ ΡΠΈΠ»Π°Π΄Π΅ virilis, Ρ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ ΠΎΡΠ²Π΅ΡΠ° Π½Π° Π’Π¨. ΠΠ°Π½Π½ΡΠ΅ Π²ΠΈΠ΄Ρ ΠΎΠ±ΠΈΡΠ°ΡΡ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΊΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΡΡΠ°Ρ ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, Π΄ΠΎΠ»ΠΆΠ½Ρ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΏΠΎ ΠΏΡΠΈΡΠΏΠΎΡΠΎΠ±Π»ΡΠ΅ΠΌΠΎΡΡΠΈ ΠΊ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΡΡΠΎΠΊΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡ. Π‘ΡΠ°Π²Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠ°ΡΡ Π²ΠΈΠ΄ΠΎΠ², ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΡΡ ΠΏΠΎ ΡΡΠΎΠ²Π½Ρ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ: D. virilis — D. lummei ΠΈ D. novamexicana — D. texana. ΠΠ°Π½Π½ΡΠ΅ ΠΏΠ°ΡΡ Π²ΠΈΠ΄ΠΎΠ² ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΡΠΊΡΠ΅ΡΠΈΠ²Π°ΡΡΡΡ Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ°ΡΡΠΈΡΠ½ΠΎ ΡΠ΅ΡΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π°. D. virilis ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅Π΄ΠΊΠΎΠ²ΡΠΌ Π²ΠΈΠ΄ΠΎΠΌ Π²ΡΠ΅ΠΉ Π³ΡΡΠΏΠΏΡ Π²ΠΈΠ΄ΠΎΠ² virilis, Ρ ΠΊΠΎΡΠΎΡΡΡ Ρ ΠΎΡΠΎΡΠΎ ΠΈΠ·ΡΡΠ΅Π½Ρ ΠΊΠ°ΡΠΈΠΎΡΠΈΠΏ ΠΈ ΡΠΈΠ»ΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ. ΠΡΠ΅ΠΌΡ Π΄ΠΈΠ²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ Π²ΠΈΠ΄ΠΎΠ² D. virilis — D. lummei ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ ~ 4 — 5 ΠΌΠ»Π½. Π»Π΅Ρ. ΠΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠ²Π΅ΡΠ΅Π½Π½ΠΎΡΡΡΡ ΡΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ, ΡΡΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π’Π¨ Ρ Π΄Π°Π½Π½ΡΡ Π²ΠΈΠ΄ΠΎΠ² ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ, Π° Π½Π΅ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠ»ΡΡΠ°ΠΉΠ½ΡΠΌΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ Π² Ρ ΠΎΠ΄Π΅ ΡΠ²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ Π΄ΠΈΠ²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ. ΠΡΡΠΏΠΏΠ° virilis ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π΄ΡΠ΅Π²Π½ΠΈΡ Π³ΡΡΠΏΠΏ ΠΏΠΎΠ΄ΡΠΎΠ΄Π° Drosophila, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΠ·ΡΡΠΈΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΡΡΠ°ΠΏΡ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70 ΠΏΡΡΡΠΌ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ ΡΡΡΡΠΊΡΡΡΠΎΠΉ Π³Π΅Π½ΠΎΠ² Π΄ΡΡΠ³ΠΈΡ Π²ΠΈΠ΄ΠΎΠ² (D. melanogaster). Π¦Π΅Π»ΡΡ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ Π³Π΅Π½ΠΎΠ² hsp70, Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ Ρ Π±Π»ΠΈΠ·ΠΊΠΎΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ Π²ΠΈΠ΄ΠΎΠ² ΡΠΈΠ»Π°Π΄Ρ virilis ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ Π΄ΡΡΠ³ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ ΡΠΎΠ΄Π° Drosophila. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π±ΡΠ»ΠΈ ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π·Π°Π΄Π°ΡΠΈ:
1. Π‘ΡΠ°Π²Π½ΠΈΡΡ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ Π²ΠΈΠ΄ΠΎΠ² D. virilis, D. lummei, D. iexana ΠΈ D. novamexicana, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅ΡΠΈΠΏΡΠΎΠΊΠ½ΡΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΎΠ² D. virilis x D. lummei.
2. ΠΠ·ΡΡΠΈΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΅Ρ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π½Π° ΡΠ°Π·Π½ΡΡ ΡΡΠΎΠ²Π½ΡΡ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ ΠΠ’Π¨70 Ρ Π²ΠΈΠ΄ΠΎΠ² Π³ΡΡΠΏΠΏΡ virilis, ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΡΡ ΠΏΠΎ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌ ΡΡΠ΅Π΄Ρ ΠΎΠ±ΠΈΡΠ°Π½ΠΈΡ.
3. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°ΡΡ Π³Π΅Π½Ρ hsp70 D. virilis ΠΈ D. lummei, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΈΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΡ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΎΠ±ΡΡΡ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ»Π°ΡΡΠ΅ΡΠ° ΠΈ ΡΠΈΡΠ»ΠΎ ΠΊΠΎΠΏΠΈΠΉ Π³Π΅Π½ΠΎΠ² hsp70 D. virilis ΠΈ D. lummei.
4. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ Π³Π΅Π½ΠΎΠ² hsp70 ΠΈ ΠΏΠ°ΡΡΠ΅ΡΠ½Π° ΠΠ’Π¨70 D. virilis ΠΈ D. lummei Ρ Π΄Π°Π½Π½ΡΠΌΠΈ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠΌΠΈ Π΄Π»Ρ Π΄ΡΡΠ³ΠΈΡ Π²ΠΈΠ΄ΠΎΠ² Diptera, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΎΠ±ΡΠ΅Π΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² hsp70 Π² Π΄Π°Π½Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΈ ΠΈΡ ΡΡΠ°ΡΡΠΈΠ΅ Π² ΡΠ΅ΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ.
1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ.
5. ΠΡΠ²ΠΎΠ΄Ρ.
1. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΆΠ½ΡΠ΅ Π²ΠΈΠ΄Ρ D. virilis ΠΈ D. novamexicana Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΉ Π±Π°Π·ΠΎΠ²ΠΎΠΉ ΠΈ ΠΈΠ½Π΄ΡΡΠΈΠ±Π΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΠΎΠ»Π΅ΡΠ°Π½ΡΠ½ΠΎΡΡΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ D. lummei ΠΈ D. texana, ΠΎΠ±ΠΈΡΠ°ΡΡΠΈΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠ»ΠΈΠΌΠ°ΡΠ°. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ»Π½ΠΎΠ΅ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅ΠΌΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ Ρ D. lummei.
2. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²ΡΠ΅ ΡΠ΅ΡΠΌΠΎΠ°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π²ΠΈΠ΄Ρ Drosophila Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠΌ ΠΠ’Π¨70 ΠΈ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΠ’Π¨ ΠΏΡΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡΡ Π’Π¨, Π±Π»ΠΈΠ·ΠΊΠΈΡ ΠΊ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ. ΠΠ°ΠΏΡΠΎΡΠΈΠ², Ρ D. lummei Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΠ’Π¨70 ΠΏΡΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ΅ 40,0Β°Π‘. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΠ’Π¨70 Ρ D. lummei Π²ΡΠ·Π²Π°Π½ΠΎ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠ΅ΡΠΌΠΎΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡΡ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΠΈ ΡΡΠ°Π½ΡΠ»ΡΡΠΈΠΈ.
3. ΠΠ·ΡΡΠ΅Π½ ΠΏΠ°ΡΡΠ΅ΡΠ½ ΠΠ’Π¨70 Π²ΠΈΠ΄ΠΎΠ² Drosophila Π³ΡΡΠΏΠΏΡ virilis. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π΄Π²ΡΡ Π³ΡΡΠΏΠΏ ΠΠ’Π¨70 Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΎΠΉ 70 ΠΈ 72 ΠΊΠΠ° ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌΠΈ ΠΈΠ·ΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΊΠΈΠ±Π΅Π»ΠΎΠΊ 70 ΠΊΠΠ° Π³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ΅Π½ ΠΠ’Π¨70, Π° Π±Π΅Π»ΠΎΠΊ Ρ ΠΌΠ°ΡΡΠΎΠΉ 72 ΠΊΠΠ° Π³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ΅Π½ ΠΠ’Π¨68 D. melanogaster.
4. ΠΠ·ΡΡΠ΅Π½Π° ΡΡΡΡΠΊΡΡΡΠ° ΠΊΠ»Π°ΡΡΠ΅ΡΠ° Π³Π΅Π½ΠΎΠ² hsp70 D. virilis ΠΈ D. lummei. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π² ΠΊΠ»Π°ΡΡΠ΅ΡΠ΅ Π³Π΅Π½ΠΎΠ² hsp70 D. virilis ΠΈ D. lummei Π΄Π²ΡΡ ΠΊΠΎΠΏΠΈΠΉ Π² Π²ΠΈΠ΄Π΅ ΠΈΠ½Π²Π΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠΎΡΠ°, ΠΊΠ°ΠΊ ΡΡΡΡΠΊΡΡΡΡ, ΡΠ²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎ ΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΠΎΠΉ Ρ ΠΎΡΡΡΠ΄Π° Diptera, ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠ»Π° ΡΠ°Π½Π΄Π΅ΠΌΠ½ΠΎ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΠΎΠΏΠΈΠΉ Ρ ΡΠ°Π·Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ.
5. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½Ρ Π³Π΅Π½Ρ hsp70 D. virilis ΠΈ D. lummei. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΠΈΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½Π°Ρ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΠΉ ΡΡΠ°ΡΡΠΎΠΊ, 5'- ΠΈ 3 '-ΡΠ»Π°Π½ΠΊΠΈΡΡΡΡΡΡ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ, Π² ΡΠΎΡΡΠ°Π²Π΅ 3'-ΡΠ»Π°Π½ΠΊΠΈΡΡΡΡΠ΅ΠΉ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ ΠΏΠΎΠ²ΡΠΎΡ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΡΠ²Π»ΡΡΡΠΈΠΉΡΡ Π΄ΡΠ΅Π²Π½ΠΈΠΌ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΠΌ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠΌ. ΠΡΡΠΊΠ°Π·Π°Π½Π° Π³ΠΈΠΏΠΎΡΠ΅Π·Π° ΠΎ Π΅Π³ΠΎ ΡΡΠ°ΡΡΠΈΠΈ Π² ΡΠ°Π½Π΄Π΅ΠΌΠ½ΡΡ Π΄ΡΠΏΠ»ΠΈΠΊΠ°ΡΠΈΡΡ ΠΈ/ΠΈΠ»ΠΈ Π΄Π΅Π»Π΅ΡΠΈΡΡ Π³Π΅Π½ΠΎΠ² hsp70 D. virilis ΠΈ D. lummei.
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