Эволюция редактируемых генов митохондриального генома трипаносоматид

выводы.

1. По структуре и длине редактируемого домена криптогены митохондриального генома трипаносоматид могут быть объединены в три группы: 1) криптогены с редукцией длины редактируемого домена, 2) криптогены с короткими консервативными редактируемыми доменами и 3) криптогены с вариабельной первичной структурой, транскрипты которых редактируются по всей длине (вариабельные полностью редактируемые криптогены).

2. Виды, криптогены которых претерпевают определенную степень редукции длины РД (5' редактируемая форма, минимально редактируемый ген) объединяются на филогенетическом дереве в разные группы.

Редукция длины редактируемых доменов криптогенов А6, СОШ, №)8 происходит согласованно в группах 1Х¥и эндосимбионт-содержащих видов.

3. Структура криптогенов с короткими консервативными РД коррелирует с максикольцевым кодированием генов гРНК, необходимых для редактирования этих криптогенов.

4. Для полностью редактируемых криптогенов с вариабельной структурой характерны преимущественно миникольцевая локализация генов гРНК и альтернативное редактирование транскриптов.

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