ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ² Π²ΠΎΠ΄Π½ΠΎ-ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΌΠ΅ΡΠ΅ΠΉ ?-Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠΌ ΠΈ ΠΏΠΎΠ»ΠΈ-N-6-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄ΠΎΠΌ
![ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ: ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ² Π²ΠΎΠ΄Π½ΠΎ-ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΌΠ΅ΡΠ΅ΠΉ ?-Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠΌ ΠΈ ΠΏΠΎΠ»ΠΈ-N-6-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄ΠΎΠΌ](https://gugn.ru/work/3429957/cover.png)
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΠΈ Π²ΡΠ½ΠΎΡΠΈΠΌΡΠ΅ Π½Π° Π·Π°ΡΠΈΡΡ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ. Π Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠΉ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ² ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΡΡΠΈΡΡΠΌ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΡΠΎΡΡΠΎΠΌ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π΅Π³ΠΎ ΡΡΠΎΠ΄ΡΡΠ²ΠΎ ΠΊ Π³ΠΈΠ΄ΡΠΎΡΠΎΠ±Π½ΡΠΌ ΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΊΡΡΠΏΠ½ΡΠΌ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΠΌ ΡΠΎΡΠ±Π°ΡΠ°ΠΌ, ΡΠ°ΠΊ ΠΆΠ΅ ΠΊΠ°ΠΊ ΠΈ Π² ΡΠ»ΡΡΠ°Π΅ Π±Π΅Π»ΠΊΠΎΠ², ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ ΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Π΅Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ. ΠΡΠΈ ΡΡΠΎΠΌ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. ΠΠΠ’ΠΠ ΠΠ’Π£Π ΠΠ«Π ΠΠΠΠΠ
- 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π±Π΅Π»ΠΊΠΎΠ² ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² ΠΊΠ°ΠΊ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ²
- 1. 2. Π’Π΅ΡΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΠΎΡΠ±ΡΠΈΠΈ Π²ΠΎΠ΄Ρ ΠΈ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π½Π° ΡΠ²Π΅ΡΠ΄ΡΡ
Π±Π΅Π»ΠΊΠ°Ρ
ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Ρ
- 1. 2. 1. Π‘ΠΎΡΠ±ΡΠΈΡ Π² Π΄Π²ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ Π±Π΅Π»ΠΎΠΊ + ΡΠΎΡΠ±Π°Ρ ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ + ΡΠΎΡΠ±Π°Ρ. ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΎΡΠ±ΡΠΈΠΈ
- 1. 2. 2. Π‘ΠΎΡΠ±ΡΠΈΡ ΠΈ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Π² ΡΡΠ΅Ρ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ Π±Π΅Π»ΠΎΠΊ ΠΈΠ»ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ + Π²ΠΎΠ΄Π° + ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ
- 1. 2. 3. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π½Π° ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ²Π΅ΡΠ΄ΡΡ Π±Π΅Π»ΠΊΠΎΠ², Π½Π° ΠΈΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π² Π²ΠΎΠ΄Π½ΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ
- 1. 3. ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ Π±Π΅Π»ΠΊΠΎΠ² ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ Π½Π΅ ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΡΠΎΡΠ±ΡΠΈΠ΅ΠΉ
- 1. 3. 1. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π²ΠΎΠ΄Ρ Π½Π° ΠΊΠΈΠ½Π΅ΡΠΈΠΊΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½ — Π°Π½ΡΠΈΡΠ΅Π»ΠΎ. ΠΡΡΠ΅ΠΊΡΡ ΠΏΠ°ΠΌΡΡΠΈ Π±Π΅Π»ΠΊΠΎΠ² (ΠΈΡΡΠΎΡΠΈΡ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ)
- 1. 3. 2. ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΠ°Π·ΠΎΠ²ΡΠ΅ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Ρ ΡΠ΅ΡΠΌΠΎΡΡΠΎΠΏΠ½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Π² Π²ΠΎΠ΄Π½ΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠ°Ρ ΠΈ Π²ΠΎΠ΄Π½ΠΎ-ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΌΠ΅ΡΡΡ
- 1. 4. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠΎΠ²
- ΠΠΠΠΠ 2. ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠΠ¬ΠΠΠ― Π§ΠΠ‘Π’
- 2. 1. ΠΠ±ΡΠ΅ΠΊΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 2. 2. ΠΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ° ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠ·ΠΎΡΠ΅ΡΠΌ ΡΠΎΡΠ±ΡΠΈΠΈ
- 2. 3. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠ·ΠΎΡΠ΅ΡΠΌ ΡΠΎΡΠ±ΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ² ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
- 2. 4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΡ ΡΠΈΡΡΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡΡ ΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ Π² Π»ΠΈΠΏΠΈΠ΄Π°Ρ
- ΠΠΠΠΠ 3. ΠΠΠ‘Π£ΠΠΠΠΠΠ Π ΠΠΠ£ΠΠ¬Π’ΠΠ’ΠΠ
- 3. 1. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΡΠΎΡΠ±ΡΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π²ΡΡΡΡΠ΅Π½Π½ΡΠΌ (3-Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠΌ
- 3. 2. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ, ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΡΠ΅ΡΠ΅ΠΏ-ΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π -Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Π° ΠΈ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π°
3.3. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π½Π° ΠΈΡ ΡΠΎΡΠ±ΡΠΈΡ Π²ΡΡΡΡΠ΅Π½Π½ΡΠΌ ΠΏΠΎΠ»ΠΈ-Π-Π±-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄ΠΎΠΌ Π² Π±ΠΈΠ½Π°ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ . ΠΡΠ΅Π½ΠΊΠ° Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΡΡΠΈ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² Π²ΡΡΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈ-Π«-6-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π°.
3.4. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΡΡΠΎΠ΄ΡΡΠ²ΠΎ ΠΏΠΎΠ»ΠΈ-Π«-Π±-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π° ΠΊ ΠΏΠ°ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌ
3.5. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ° Π½Π° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΠΎ-Π»ΠΈ-Π-Π±-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π°.
ΠΠ«ΠΠΠΠ«.
ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ² Π²ΠΎΠ΄Π½ΠΎ-ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΌΠ΅ΡΠ΅ΠΉ ?-Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠΌ ΠΈ ΠΏΠΎΠ»ΠΈ-N-6-Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄ΠΎΠΌ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ. Π’Π΅ΡΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ²Π΅ΡΠ΄ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΈ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π²Π»ΠΈΡΡΡΠΈΡ Π½Π° ΡΡΠΎΡ ΠΏΡΠΎΡΠ΅ΡΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π³Π»ΡΠ±ΠΆΠ΅ ΠΏΠΎΠ½ΡΡΡ ΡΠΎΠ»Ρ Π²ΠΎΠ΄Ρ Π² ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π±Π΅Π»ΠΊΠΎΠ² ΡΠ²ΡΠ·ΡΠ²Π°ΡΡ ΡΡΠ±ΡΡΡΠ°ΡΡ ΠΈ Π²ΡΡΠ²ΠΈΡΡ Π²Π°ΠΆΠ½ΡΠ΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠΌ Π΄ΠΎΠ»ΠΆΠ½Ρ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΡΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ Π΄Π»Ρ ΡΠΎΠ³ΠΎ, ΡΡΠΎΠ±Ρ ΠΈΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±ΡΠ»ΠΈ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½Ρ. ΠΠ½Π°Π½ΠΈΠ΅ ΡΡΠΈΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ·Π°ΠΉΠ½Π° Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ ΠΈ Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠ΅Π½ΡΠΎΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π»Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° Π»Π΅ΠΊΠ°ΡΡΡΠ² ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΊΠ°Π½Π΅ΠΉ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ ΡΠ΅Π»ΡΡ . ΠΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ Π²ΠΎΠ΄Ρ ΠΈΠ·Π²Π΅ΡΡΠ½Ρ Π΄Π»Ρ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ, Π΄Π»Ρ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ Π²ΠΎΠ΄Ρ ΠΈΠ· Π²ΠΎΠ΄Π½ΠΎ-ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΌΠ΅ΡΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π»Ρ ΡΠ΅ΡΠΌΠΎΡΡΠΎΠΏΠ½ΡΡ ΡΠ°Π·ΠΎΠ²ΡΡ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ΠΎΠ² Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠ²ΠΎΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² Π² Π½Π°ΡΠΈΠ²Π½ΡΡ ΡΡΡΡΠΊΡΡΡΡ. ΠΠΎΠ»ΡΡΠ°Ρ ΡΠ°ΡΡΡ ΡΡΠΈΡ Π΄Π°Π½Π½ΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π° Π΄Π»Ρ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ², ΠΈΠ·-Π·Π° ΡΠ΅Π³ΠΎ ΠΈΡ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π°ΡΡΡΠ΄Π½Π΅Π½Π° Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΡΡΠΈΠΌ Π²ΠΊΠ»Π°Π΄ΠΎΠΌ Π΄Π΅Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ ΡΡΠ±ΡΡΡΠ°ΡΠ° ΠΏΠ΅ΡΠ΅Π΄ Π΅Π³ΠΎ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ΠΌ Π±Π΅Π»ΠΊΠΎΠΌ ΠΈΠ»ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠΌ. ΠΠ°Π½Π½ΡΠ΅ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π²Π½Π΅ΡΠ½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² (ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ° ΠΈ ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ) Π½Π° ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π΄Π»Ρ Π±Π΅Π»ΠΊΠΎΠ² Π² ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΆΠΈΠ΄ΠΊΠΎΠΉ ΡΠ°Π·Ρ ΠΈ ΠΎ ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠΈ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° Π΄Π»Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ² Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΎΡΡΡΡΡΡΠ²ΡΡΡ.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ. Π¦Π΅Π»ΡΠΌΠΈ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ»ΠΎΡΡ:
— ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠ΅ΠΉ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠΎΡΠ±-ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΡΠ΅ΠΊΠ»ΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΠ³ΠΎ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΈΡΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ° Ρ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΡΡΠΈ Π΅Π³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ².
— ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ².
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΠΈ Π²ΡΠ½ΠΎΡΠΈΠΌΡΠ΅ Π½Π° Π·Π°ΡΠΈΡΡ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ. Π Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠΉ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΠΏΡΠΈ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ² ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΡΡΠΈΡΡΠΌ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΡΠΎΡΡΠΎΠΌ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π΅Π³ΠΎ ΡΡΠΎΠ΄ΡΡΠ²ΠΎ ΠΊ Π³ΠΈΠ΄ΡΠΎΡΠΎΠ±Π½ΡΠΌ ΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΊΡΡΠΏΠ½ΡΠΌ Π³ΠΈΠ΄ΡΠΎΡΠΈΠ»ΡΠ½ΡΠΌ ΡΠΎΡΠ±Π°ΡΠ°ΠΌ, ΡΠ°ΠΊ ΠΆΠ΅ ΠΊΠ°ΠΊ ΠΈ Π² ΡΠ»ΡΡΠ°Π΅ Π±Π΅Π»ΠΊΠΎΠ², ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ ΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Π΅Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ. ΠΡΠΈ ΡΡΠΎΠΌ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΡΡΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ-Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² Π³ΠΈΠ΄ΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ° ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΎΡΠ±Π°ΡΠ°ΠΌ Π²ΡΡΠ°ΠΆΠ΅Π½Π° ΡΠ΅ΠΌ Π±ΠΎΠ»ΡΡΠ΅, ΡΠ΅ΠΌ ΠΌΠ΅Π½ΡΡΠ΅ ΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΏΠ»Π°ΡΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ Π²ΡΡΡΡΠ΅Π½Π½ΡΠΉ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ. ΠΠ°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ΄Π΅Π»Π°ΡΡ Π²ΡΠ²ΠΎΠ΄ Π² ΠΏΠΎΠ»ΡΠ·Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π°ΡΡΠ°ΡΠΎΠ² Π²ΠΎΠ΄Π° + ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ + ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ.
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΎΡ ΠΊΠΎΠΌΠ½Π°ΡΠ½ΠΎΠΉ (298 Π) Π΄ΠΎ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ (309.5 Π) ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΠΎΠ³Π° ΠΏΠΎ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ, Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π΄Π»Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² Π±Π΅Π»ΠΊΠ°ΠΌ. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ ΡΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌ Π²ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡΠΈΡ Π² Π±Π΅Π»ΠΊΠ΅, Π½Π° Π΅Π³ΠΎ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΡΡΠΎΠ΄ΡΡΠ²ΠΎ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π΄Π°Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π½Π΅ ΡΠ²ΡΠ·Π°Π½ Ρ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΎΡΠ±Π°ΡΠΎΠ² Π² ΠΎΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΡΠ°Π·Π΅ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ².
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠΎΡΡΠΎΠΈΡ Π² ΡΠΎΠΌ, ΡΡΠΎ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π΅Π΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠΌ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΠ½ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π², Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΡ Π΄Π»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΠ·Π°ΠΉΠ½Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠ², ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠΌΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π½Π° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅Π½ΡΠΎΡΠΎΠ², Π½Π΅ ΡΡΡΡΠΏΠ°ΡΡΠΈΡ ΠΏΠΎ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Π½ΡΠΎΡΠ°ΠΌ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±Π΅Π»ΠΊΠΎΠ². ΠΠ°Π½Π½ΡΠ΅ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π½Π° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΎΡΠ½ΠΎΠ²Ρ Π΄Π»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΡ Π·Π°ΠΏΠ°Ρ ΠΎΠ² Π² Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ , ΡΠ΄Π΅ΡΠΆΠΈΠ²Π°Π½ΠΈΡ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π΄ΠΎΠ±Π°Π²ΠΎΠΊ ΠΈ Π²ΡΠ΅Π΄Π½ΡΡ Π²Π΅ΡΠ΅ΡΡΠ² ΠΏΠΈΡΠ΅Π²ΡΠΌΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠ°ΠΌΠΈ.
ΠΠ±ΡΠ΅ΠΌ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° ΡΠ°Π±ΠΎΡΡ. ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Π° Π½Π° 138 ΡΡΡΠ°Π½ΠΈΡΠ°Ρ ΠΌΠ°ΡΠΈΠ½ΠΎΠΏΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΊΡΡΠ° ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 43 ΡΠΈΡΡΠ½ΠΊΠ° ΠΈ 32 ΡΠ°Π±Π»ΠΈΡΡ. ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· Π²Π²Π΅Π΄Π΅Π½ΠΈΡ, ΡΡΠ΅Ρ Π³Π»Π°Π² (ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ, ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²), Π²ΡΠ²ΠΎΠ΄ΠΎΠ², ΡΠΏΠΈΡΠΊΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈΠ· 112 Π½Π°ΠΈΠΌΠ΅Π½ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈ ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ.
1. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π½Π° ΡΠΎΡΠ±ΡΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅ Π½ΠΈΠΉ Π³ΠΈΠ΄ΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ. ΠΠ»Ρ Π -Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Π° ΠΈ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅ Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΎΡ ΠΊΠΎΠΌΠ½Π°ΡΠ½ΠΎΠΉ (298 Π) Π΄ΠΎ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ (309.5 Π) ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΠΈΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΠΎΠ³Π° ΠΏΠΎ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ, Π²ΡΡΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡ Ρ ΠΎΠ΄ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² ΡΡΠΈΠΌΠΈ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ.2. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π²Ρ ΡΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈ Π³ΠΈΠ΄ΡΠ°ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ ΡΠΈΠ½Π΅ΡΠ³ΠΈΠ·ΠΌ Π²ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π³ΠΈΠ΄ΡΠ° ΡΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠΈΠΌΠ΅ΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡΠΈΡ Π² |3-Π»Π°ΠΊΡΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Π΅, Π½Π° ΠΊΠΎΠΎΠΏΠ΅ΡΠ° ΡΠΈΠ²Π½ΡΠΉ ΡΠΎΡΡ Π΅Π³ΠΎ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ΄ΡΡΠ²Π° ΠΊ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π°ΠΌ.3. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΈΠ·ΠΎΡΠ΅ΡΠΌΡ ΡΠΎΡΠ±ΡΠΈΠΈ, Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΠΎΡΠ± ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ΄ΡΡΠ²Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ° ΠΊ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌ ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π΅Π³ΠΎ Π³ΠΈΠ΄ ΡΠ°ΡΠ°ΡΠΈΠΈ Π² ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΆΠΈΠ΄ΠΊΠΎΠΉ ΡΠ°Π·Ρ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ΅ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠ°ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΡΡΠΎΠ΄ΡΡΠ²ΠΎ ΡΡΠΈΡΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈ-Π«-6;
Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π° ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΊΡΡΠΏΠ½ΡΠΌ ΡΠΎΡΠ±Π°ΡΠ°ΠΌ.4. Π ΡΡΠ΅Ρ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ Ρ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΡΡΠΈΡΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈ-Π-Π± Π°ΠΌΠΈΠ½ΠΎΠ³Π΅ΠΊΡΠΈΠ»Π°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π° ΠΈ Π΄Π²ΡΡ Π»Π΅ΡΡΡΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π±ΠΈΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ΅ ΠΊΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠ»ΠΎΡ ΠΈΡ ΠΏΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΎΡΠΎΠ² Π½Π° ΡΠΎΡΠ±ΡΠΈΡ ΡΡΠ° Π½ΠΎΠ»Π° ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΎΠΌ.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- Haertle T. Probing the fatty acid binding site of p-lactoglobulins / D. Frapin, E. Dufour, T. Haertle // J. Prot Chem. — 1993. — V. 12. — P.443−449.
- Sawyer L. P-Lactoglobulin binds palmitate within its central cavity / S.-Y. Wu, M.D. Perez, P. Puyol, L. Sawyer // J. Biol. Chem. — 1999. — V.274. — P.170−174.
- Pevsner J. Odorant-binding protein, characterization of ligand binding / J. Pevsner, V. Hou, A.M. Snowman, S.H. Snyder // J. Biol. Chem — 1990. — V.265. -P.6118−6125.
- Allen K.N. An experimental approach to mapping the binding sites of crystalline proteins / K.N. Allen, C.R. Bellamacina, X. Ding, C.J. Jeffery, C. Mattos, G.A. Petsko, D. Ringe // J. Phys. Chem. -1996. — V.100, N7. — P.2605−2611.
- Fitzpatrick P.A. Enzyme crystal structure in a neat organic solvent / P.A. Fitz- patrick, A.C.U.Steinmetz, D. Ringe, A.M.Klibanov // Proc. Natl. Acad. Sci. USA. — 1993. — V.90, N18. — P.8653−8657.
- Fitzpatrick P.A. X-ray crystal structure of cross-linked subtilisin Carlsberg in water vs. acetonitrile / P.A. Fitzpatrick, D. Ringe, A.M. Klibanov // Biochem. Biophys. Res. Commun. — 1994. — V.198, N2. — P.675−681.
- Schmitke J.L. Organic solvent binding to crystalline subtilisin 1 in mostly aque ous media and in the neat solvents / J.L. Schmitke, L.J. Stern, A.M. Klibanov // Biochem. Biophys. Res. Commun. -1998. — V.248, N2. — P.273−277.
- Klibanov A.M. The crystal structure of subtilisin carlsberg in anhydrous diox- ane and its comparison with those in water and acetonitrile / J.L. Schmitke, L.J. Stern, A.M. Klibanov // Proc. Natl. Acad. Sci. USA — 1997. — V.94. — P.4250−4255.
- Wang Z. X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixtures / Z. Wang, G. Zhu, M. Qian, M. S hao, Y. Jia, Y. Tang // Biochim. Bio phys. Acta — 1998. — V. 1384. — P.335−344.
- Zhu G. X-ray studies on two forms of bovine p-trypsin crystals in neat cyclo- hexane / G. Zhu, Q. Huang, Z. Wang, M. Qian, Y. Jia, Y. Tang // Biochim. Bio phys. Acta. — 1998. -V.1429. -P.142−150.
- Yennawar N.H. X-ray crystal structure of y-chymotrypsin in hexane / N.H. Yennawar, H.P. Yennawar, G.K. Farber // Biochemistry — 1994. — V.33. -P.7326−7336.
- Yennawar H.P. A structural explanation for enzyme memory in nonaqueous solvents / H.P. Yennawar, N.H. Yennawar, G.K. Farber // J. Am. Chem. Soc. -1995.-V.117,N2.-P.577−585.
- Sellergen B. Polymer- and template-related factors influencing the efficiently in molecularly imprinted solid-phase extractions / B. Sellergen // Trends Anal. Chem. — 999. — V.18. -P.164−174.
- Haupt K. Molecularly imprinted polymers and their use in biomimetic sensors / K. Mosbach, K. Haupt // Chem. Rev. — 2000. — V.100. — P.2495−2504.
- Dickert F.L. Molecular imprints in chemical sensing — detection of aromatic and halogenated hydrocarbons as well as polar solvents / F.L. Dickert, P. Forth, P. 1. ieberzeit, M. Tortschanoff// J. Anal. Chem. — 1998. — V.360. — P.759−762.
- Dickert F.L. Molecular imprints as artificial antibodies — a new generation of chemical sensors / F.L. Dickert, P. Lieberzeit, M. Tortschanoff // Sensors and Actuators Π — 2000. — V.65. — P. 186−189.
- Kulkarni M.G. Molecularly imprinted polymers mimics of chymotrypsine. 1. Cooperative effect and substrate specificity / B.S. Lele, M.G. Kulkarni, R. A Mashelkar // React. Func. Polym. — 1999. — V.39. — P.37−52.
- Horkay F. Swelling behavior of emulsion polymer particles: comparison between fully cross-linked and partially cross-linked poly (acrylate) latexes / F. Horkay, D.H. Craig // Polym. Bull. — 1998. — V.41. — P.231−237.
- Dworak A. Polyglycidol-block-poly (ethylene oxide)-block-polyglycidol: synthesis and swelling properties / A. Dworak, G. Baran, B. Trzebicka, W. Walach // Reactive and Functional Polymers — 1999. — V.42. — P.31−36.
- Russell AJ. The role of hydration in enzyme activity and stability: 1. Water adsorption by alcohol dehydrogenase in a continuous gas phase reactor / F. Yang, A. J. Russell // Biotechnol. Bioeng. — 1996. — V.49. — P.700−708.
- Hnojewyj W.S. Further studies on the sorption of H20 and D20 vapors by ly- sozyme and the deuterium-hydrogen exchange effect / W.S. Hnojewyj, L.H. Reyerson // J. Phys. Chem. — 1961. — V.65. — P. 1694−1698.
- Brausse G. Water adsorption and dielectric properties of lyophilized hemoglobin / G. Braurse, A. Mayer, T. Nedetzka, P. Schlect, H. Vogel // J. Phys. Chem. — 1968. — V.72. — P.3098 — 3105.
- Bull H.B. Adsorption of water vapor by proteins / H.B. Bull // J. Am. Chem. Soc. — 1944. — V.66, N9. — P.1499−1507.
- Zografi G. Water vapor sorption by peptides, proteins and their formulations / S.L. Shamblin, B.C. Hancockb, G. Zografi // European Journal of Pharmaceutics and Biopharmaceutics — 1998. — V.45. — P.239−247.
- Gregory R.B. Protein hydration and glass transition behavior, in: R. B. Gregory (Ed.), Protein-Solvent Interactions / R.B. Gregory. — New York: Marcel Dekker Inc., 1995.-P.191−263.
- Brunauer S. Adsorption of gases in multimolecular layers / S. Brunauer, P.H. Emmett, E. Teller // J. Am. Chem. Soc. — 1938. — V.60, N2. — P.309−319.
- Boki K. Structural analysis of collagen fibers by nitrogen adsorption method / K. Boki, N. Kawasaki, K. Minami, H. Takahashi // J. Colloid Interface Sci. -1993.-V.157.-P.55−59.
- Boki K. Moisture sorption properties of collagen varied in polarity and porous structure by alkali-treatment. / K. Boki, N. Kawasaki, H. Takahashi // J. Colloid Interface Sci. — 1993. — V.161.-P.148−154.
- Vrentas J.S. Hysteresis effects for sorption in glassy polymers / J.S. Vrentas, CM. Vrentas // Macromolecules — 1991. — V.24. — P.2404−2412.
- Vrentas J.S. Sorption in glassy polymers / J.S. Vrentas, CM. Vrentas // Macromolecules — 1996. — V.29. — P.4391−4396.
- Dlubek G. Humidity-induced plasticization and antiplasticization of Polyamide 6: af) ositron lifetime study of thelocal free volume / G. Dlubek, F. Redmann, R. Krause-Rehberg // J. Appl. Polym. Sci. — 2002. — V.84. — P.244 — 255.
- McDowell C.C. Acetone sorption and uptake kinetic in poly (ethylene terephtha- late) / C. C McDowell, B.D. Freeman, G.W. McNeely // Polymer — 1999. -V.40.-P.3487−3499.
- Ogilby P.R. Oxygen diffusion in glassy polymer films: effect of other gases and changes in pressure / L. Poulsen, P.R. Ogilby // J. Phys. Chem. A — 2000. -V.104.-P.2573−2580.
- Stern S.A. Representation of gas solubility in glassy polymers by a concentration-temperature superposition principle / Y. Mi, S. Zhou, S.A. Stern // Macro-molecules — 1991. — V.24. — P.2361 -2367.
- Favre E. Sorption of organic solvents into dense silicone membranes / E. Favre, R. Clement, Q.T. Nguyen, P. Schaetzel, J. Neel // Chem. Soc. Faraday Trans. -1993.-V.89.-P.4347−4353.
- Sarti G.C. Solubility and diffusivity of ethanol in PTMSP: effects of activity and polymer aging / F. Doghieri, D. Biavati, G.C. Sarti // Ind. Eng. Chem. Res. — 1996 — V.35. — P.2420−2430.
- Benson S.W. Surface areas of proteins. II. Adsorption of non-polar gases / S.W. Benson, D.A. Ellis // J. Am. Chem. Soc. — 1950. — V.72. — P.2095−2102.
- Gorbatchuk V.V. Vapor sorption of organic compounds on human serum albumin / V.V. Gorbatchuk, M.A. Ziganshin, B.N. Solomonov, M.D. Borisover // J. Phys. Org. Chem. — 1997. — V.10. -P.901−907.
- Gorbatchuk V.V. Supramolecular interactions of solid human serum albumin with binary mixtures of solvent vapors / V.V. Gorbatchuk, M.A. Ziganshin, B.N. Solomonov // Biophys. Chem. — 1999. — V.81. — P.107−123.
- Castro G.R. Properties of soluble a-chymotrypsin in neat glycerol and water / G.R. Castro // Enzyme Microb. Technol. — 2000. — V.27. — P. 143−150.
- Nemat-Gorgani M. Effect of organic solvents on stability and activity of two related alfcohol dehydrogenases: a comparative study / M. Miroliaei, M. Nemat-Gorgani // Int. J. Biochem. Cell Biol. — 2002. — V.34. — P.169−175.
- ΠΡΡΠΎΠ»ΠΎΠ²ΡΠΊΠΈΠΉ Π.Π. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Π°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°Π»ΡΠ±ΡΠΌΠΈΠ½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° / Π. Π. ΠΡΡΠΎΠ»ΠΎΠ²ΡΠΊΠΈΠΉ, Π. Π. ΠΠΎΡΡΠ½ΡΠΊΠΈΠΉ, Π. ΠΠΎΡΠΈΡΠ΅Π½ΠΊΠΎ, Π. Π. Π’ΠΎΠ»ΠΊΠ°ΡΠ΅Π²Π° // ΠΠΈΠΎΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΡ ΠΈ ΠΊΠ»Π΅ΡΠΊΠ°. — 1990. — Π’.6, N5. — 59−64.
- Abundo M. A stochastic model for the sigmoidal behaviour of cooperative biological systems / M. Abundo, L. Accardi, A.F. Agro, G. Mei, N. Rosato // Bio-phys. Chem. — 1996. — V.58, N3. — P.313−323.
- ΠΠ΄ΡΠΎΠ»Π» ΠΠΆ. ΠΠΈΠΎΡΠ΅ΡΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ°. / ΠΠΆ. ΠΠ΄ΡΠΎΠ»Π», X. ΠΠ°ΡΡΡΠ΅Π½Π΄. — Π.: ΠΠΈΡ, 1986.-296 Ρ.
- Perutz M.F. Mechanism of the cooperative effects in hemoglobin revisited / M.F. Perutz, A.J. Wilkinson, M. Paoli, G.G. Dodson // Annu. Rev. Biophys. Biomol. Struct. — 1998. — V.27, N1. — P. 1−34.
- Bettati S. T state hemoglobin binds oxygen noncooperatively with allosteric effects of protons, inositol hexaphosphate, and cloride / S. Bettati, A. Mozzarelli // J. Biol. Chem. — 1997. — V.272, N51. — P.32 050−32 055.
- Mozzarelli A. Cooperative oxygen binding to Scapharca inaequivalvis hemoglobin in the crystal / A. Mozzarelli, S. Bettati, Π‘ Rivetti, G.L. Rossi, G. Colotti, E. Chiancone // J. Biol. Chem. — 1996. — V.271, N7. — P.3627−3632.
- Gorbatchuk V.V. Homotropic cooperative binding of organic solvent vapors by solid trypsin / V.V. Gorbatchuk, M.A. Ziganshin, N.A. Mironov, B.N. Solo-monov //Biochim. Biophys. Acta- 2001. — V.1545. — P.326−338.
- Xiwen H. Study of the nature of recognition in molecularly imprinted polymer selective for 2-aminopyridine / Z. Jie, H. Xiwen // Anal. Chim. Acta — 1999. V.381.-P.85−91.
- Mashelkar R.A. Enhancing adsorptive separations by molecularly imprinted polymers: Role of imprinting techniques and system parameters / V.P. Joshi, M.G. Kulkarni, R. A Mashelkar // Chem. Eng. Sci. — 2000. — V.55. — P.1509−522.
- Ladbury J.E. Just add water! The effect of water on the specificity of protein- ligand binding sites and its potential application to drug design / J.E. Ladbury // Chemistry & Biology — 1996. — V.3. — P.973−980.
- Ke T. On enzymatic activity in organic solvents as a function of enzyme history / T. Ke, A.M. Klibanov // Biotechnol. Bioeng. — 1998. — V.57, N6. — P.746−750.
- Orozco M. Theoretical methods for the description of the solvent effect in bio- molecular systems / M. Orozco, F.J. Luque // Chem. Rev. — 2000. — V.100, N11.-P.4187−4225.
- Hailing P.J. High-affinity binding of water by proteins is similar in air and in organic solvents / P.J. Hailing // Biochim. Biophys. Acta. — 1990. — V.1040. -P.225−228.
- Borisover M.D. Thermodynamics of water binding by human serum albumin suspended in acetonitrile / M.D. Borisover, V.A. Sirotkin, B.N. Solomonov // Thermochim. Acta. — 1995. — V.254, N1−2. — P.47−53.
- Borisover M.D. Interactions of human serum albumin suspended in water- organic mixtures / M.D. Borisover, V.A. Sirotkin, B.N. Solomonov // Thermo chim. Acta. — 1996. — V.284, N2. — P.263−277.
- Sirotkin V.A. Effect of chain length on interactions of aliphatic alcohols with suspended human serum albumin / V.A. Sirotkin, M.D. Borisover, B.N. Solo monov // Biophys. Chem. — 1997. — V.69. — P.239−248.
- Parker M.C. Measuring enzyme hydration in nonpolar organic solvents using NMR / M.C. Parker, B.D. Moore, A.J. Blacker // Biotechnol. Bioeng. — 1995. -V.46.-P.452−458.
- Gilli P. Enthalpy — entropy compensation in drug — receptor binding / P. Gilli, V. Ferretti, G. Gilli, P.A. Borea // J. Phys. Chem. — 1994. — V.98. — P.1515−1518.
- Setford SJ. Immunosensing in organic and mixed aqueous-organic phase envi ronments / S. J. Setford // Trends Anal. Chem. — 2000. — V. 19. — P.330−339.
- Klibanov A.M. Why are enzymes less active in organic solvents than in water? / A.M. Klibanov // Trends. Biotech. — 1997. — V.15. — P.97−101.
- Cerovsky V. Free chymotrypsin-catalyzed synthesis of peptide bond in aliphatic alcohols with low water content / V. Cerovsky, K. Martinek // Collect. Czech. Chem. Commun. — 1989. — V.54. — P.266−276.
- Partridge J. Activity and mobility of subtilisin in low water organic media: hy dration is more important than solvent dielectric / J. Partridge, P.R. Dennison, B.D. Moore, P.J. Hailing // Biochem. Biophys. Acta — 1998. — V.1386. — P.79−89.
- Hailing P.J. Thermodynamic predictions for biocatalysis in nonconventional media: theory, tests, and recommendations for experimental design and analysis / P.J. Hailing // Enzyme Microb. Technol. — 1994. — V.16. — P. 178−206.
- Yang F. The role of hydration in enzyme activity and stability: 2. Alcohol de hydrogenase activity and stability in a continuous gas phase reactor / F. Yang, A.J. Russell // Biotechnol. Bioeng. — 1996. — V.49, N6. — P.709−716.
- Barzana E. Enzyme-catalyzed, gas-phase reactions / E. Barzana, A.M. Kli banov, M. Karel // Apll. Biochem. Biotechnol. — 1987. — V.15, N1. — P.25−34.
- Parker M.C. In situ hydration of enzymes in non-polar organic media can increase the catalytic rate / M.C. Parker, B.D. Moore, A.J. Blacker // Biocatalysis. -1994.-V.10.-P.269−277.
- Russell A.J. Antibody-antigen binding in organic solvents / A.J. Russell, L.J. Trudel, P.L. Skipper, J.D. Groopman, S.R. Tannenbaum, A.M. Klibanov // Bio-chem. Biophys. Res. Commun. — 1989. — V.158, N1. — P.80−85.
- Giraudi G. Solvent effect testosterone-antitestosterone interaction / G. Giraudi, Π‘ Baggiani // Biochim. Biophys. Acta — 1993. — V. l 157. — P.211−216.
- Urry D.W. Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers / D.W. Urry // J. Phys. Chem. Π -1997. -V.101.-P.11 007−11 028.
- Galaev I.Y. 'Smart' polymers and what they could do in biotechnology and medicine / I.Y. Galaev, B. Mattiasson // TIBTECH — 1999. — V.17. — P.335−340.
- Urry D.W. Engineering protein-based machines to emulate key steps of metabolism (Biological energy conversion) / D.W. Urry, S.Q. Peng, L.C. Hayes, D. McPherson, J. Xu, T.C. Woods, D.C. Gowda, A. Pattanaik // Biotech. Bioeng. -1998.-V.58.-P.175−190.
- Barron A.E. Bioinspired polymeric materials: in-between proteins and plastics / A.E. Barron, R.N. Zuckermann // Curr. Opin. Chem. Biol. — 1999. — V.3. -P.681−687.
- Shibayama M. Thermal properties of copolymer gels containing N- isopropylacrylamide / M. Shibayama, S. Mizutani, S. Nomura // Macromole-cules — 1996. -V.29. — P.2019−2024.
- Mukae Π. Swelling of poly (N-isopropylacrylamide) gels in water-alcohol (d — C4) mixed solvents / K. Mukae, M. Sakurai, S. Sawamura, K. Makino, S.W. Kim, I. Ueda, K. Shirahama // J. Phys. Chem. — 1993. — V.97. — P.737−741.
- Chatterji P.R. Swelling and deswelling pathways in non-ionic poly (N— isopropylacrylamide) hydrogels in presence of additives / D. Dhara, P.R. Chatterji // Polymer — 2000. — V.41. — P.6133−6143.
- Koga S. Effect of hydrophobic substances on the volume-phase transition of N- isopropylacrylamide gels / S. Koga, S. Sasaki, H. Maeda // J. Phys. Chem. Π -2001.-V.105.-P.4105−4110.
- Chatterji P.R. Effect of hydrotropes on the volume phase transition in poly (N- isopropylacrylamide) hydrogel / D. Dhara, P.R. Chatterji // Langmuir — 1999. -V.15.-P.930−935.
- Yoshida M. Volume phase transitions of poly (acryloyl-L-proline methyl ester) gels in response to water-alcohol composition / A. Hiroki, Y. Maekawa, M. Yoshida, K. Kubota, R. Katakai // Polymer — 2001. — V.42. — P.1863−1867.
- Berliner L.J. Fatty acids and retinoids bind independently and simultaneously to (3-lactoglobulin / M. Narayan, L.J. Berliner // Biochemistry — 1997. — V.36. -P.1906−1911.
- Popot J.-L. Helical membrane protein folding, stability, and evolution / J.-L. Popot, D.M. Engelman // Annu. Rev. Biochem. — 2000. — V.69. — P.881−922.
- Creamer L.K. Effect of sodium dodecyl sulfate and palmitic acid on the equilibrium unfolding of bovine pMactoglobulin / L.K. Creamer // Biochemistry -1995.-V.34.-P.7170−7176.
- Pierre A. Principes pour un procede industriel de fractionnement des proteines du lactoserum. / A. Pierre, J. Fauquant // Le Lait — 1986. — V.66. — P.405−419.
- Perrin D.D. Purification of laboratory chemicals / D.D. Perrin, W.L.F. Ar- marego, D.R. Perrin. — Oxford: Pergamon Press, 1980.
- A.C. Π‘Π‘Π‘Π G 01/30/16 SU 1 567 973 Al. Π£ΡΡΡΠΎΠΉΡΡΠ²ΠΎ ΠΎΡΠ±ΠΎΡΠ° ΠΈ Π²Π²ΠΎΠ΄Π° ΠΏΡΠΎΠ± ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠ° Π² Π³Π°Π·ΠΎΠ²ΡΠΉ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°Ρ / Π. Π. ΠΠΎΡΠ±Π°ΡΡΠΊ, Π. Π‘ΠΌΠΈΡΠ½ΠΎΠ², Π. Π. ΠΠΈΡΠ½ΡΠΊΠΎΠ², Π. Π. Π‘ΠΎΠ»ΠΎΠΌΠΎΠ½ΠΎΠ², Π. Π. ΠΠΎΠ½ΠΎΠ²Π°Π»ΠΎΠ². — ΠΠΏΡΠ±Π». 1990, ΠΡΠ». N20.
- Lencka M. Verified vapor pressure data, vol. 1 / M. Lencka, A. Szafranski, A. Maczynski. Warszawa: PWN, 1984.
- Boublik T. The vapour pressures of pure substances / T. Boublik, E. Hala, V. Fried. -Amsterdam: Elsevier, 1973.
- Henderson S.M. A basic concept of equilibrium moisture / S.M. Henderson // Agr. Eng. — 1952. — V.33. — P.29−32.
- Avnir D. Chemistry in noninteger dimensions between two and three. II. Fractal surfaces of adsorbents / D. Avnir, D. Farity, P. Pfeifer // J. Chem. Phys. — 1983. -V.79,N7.-P.3566−3571.
- Burova T.V. Conformational stability and binding properties of porcine odorant binding protein / T.V. Burova, Y. Choiset, C.K. Jankowski, T. Haertle // Biochemistry-1999.-V.3 8. -P. 15 043−15 051.
- Akerstrom B. Lipocalins: unity in diversity / B. Akerstrom, D.R. Flower, J.-P. Salier // Biochim. Biophys. Acta. — 2000. — V. 1482. — P. 1−8.
- Crouzet J. Determination of apparent binding constants for aroma compounds with p-lactoglobulin by dynamic coupled column liquid chromatography / E. Jouenne, J. Crouzet // J. Agric. Food Chem. — 2000. — V.48. — P.5396−5400.
- Haertle T. p-Lactoglobulin binds retinol and protoporphyrin IX at two different binding sites / E. Dufour, M.C. Marden, T. Haertle // FEBS Letters — 1990. -V.277.-P.223−226.
- Eckert C.A. Compilation and correlation of limiting activity coefficient of nonelectrolytes in water / S.R. Sherman, D.B. Trampe, D.M. Bush, M. Schiller, C.A. Eckert, A.J. Dallas, J. Li, P.W. Carr // Ind. Eng. Chem. Res. — 1996. -V.35.-P.1044−1058.
- Carr P.E. Critical evaluation of predicted and measured gas-liquid partition coefficient in n-hexadecane / P.E. Carr, A.J. Dallas // J. Phys. Chem. — 1994. -V.98. — P.4927−4939.
- Bishop R. Designing new lattice inclusion hosts / R. Bishop // Chem. Soc. Rev. -1996.-V.25.-P.311−319.