Π‘ΠΈΠ½ΡΠ΅Π· ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π²Π½Π΅ΡΠ½Π΅ΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ
Π‘ ΡΠ΅Π»ΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ ΠΏΡΠΎΡΠΈΠ² ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π Π² ΡΠ°ΠΌΠΊΠ°Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»Π° ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Π° Π·Π°Π΄Π°ΡΠ° Π²ΡΠ±ΠΎΡΠ° ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΡΠ΅Ρ Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°: Π ΠΎΠ³Π, ΠΡΠ°Π ΠΈ NspA, Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½ΡΠ΅Π·Π° ΡΡΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ² ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ , Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ². ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ I. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π« Π ΠΠΠ¬ ΠΠΠΠΠΠ ΠΠΠ Π£ΠΠΠΠ ΠΠΠΠΠ ΠΠΠ« ΠΠΠΠ’ΠΠ ΠΠ NEISSERIA MENINGITIDIS Π Π€ΠΠ ΠΠΠ ΠΠΠΠΠΠ ΠΠΠΠ£ΠΠΠΠΠ ΠΠ’ΠΠΠ’Π
- 1. ΠΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
- 2. ΠΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ
- 3. Π£ΡΠ°ΡΡΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ Neisseria meningitidis Π² ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°
- 3. 1. ΠΠ΅Π»ΠΎΠΊ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 1 — Π ΠΎΠ³Π
- 3. 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π ΠΈ Π΅Π³ΠΎ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅
- 3. 1. ΠΠ΅Π»ΠΎΠΊ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 1 — Π ΠΎΠ³Π
- 3. 1. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π
- 3. 1. 3. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π-ΡΠΏΠΈΡΠΎΠΏΠΎΠ² Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π
- 3. 1. 4. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π’-Ρ Π΅Π»ΠΏΠ΅ΡΠ½ΡΡ ΡΠΏΠΈΡΠΎΠΏΠΎΠ² Π ΠΎΠ³Π
- 3. 1. 5. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 2. ΠΠ΅Π»ΠΊΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 2/3 — Π ΠΎΠ³Π
- 3. 2. 1. Π‘ΡΡΡΠΊΡΡΡΠ° Π±Π΅Π»ΠΊΠΎΠ² Π ΠΎΠ³Π ΠΈ ΠΈΡ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 2. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠΎΠ² Π ΠΎΠ³Π
- 3. 2. 3. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π’-ΡΠΏΠΈΡΠΎΠΏΠΎΠ² Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π
- 3. 3. ΠΠ΅Π»ΠΎΠΊ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 4 — Rmp
- 3. 3. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° Rmp Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 3. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° Rmp
- 3. 4. ΠΠ΅Π»ΠΊΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ°
- 3. 4. 1. Π‘Π΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Π±Π΅Π»ΠΊΠΎΠ² ΠΡΠ°
- 3. 4. 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ² ΠΡΠ° Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 4. 1. 2. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π-ΡΠΏΠΈΡΠΎΠΏΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² ΠΡΠ°
- 3. 4. 1. 3. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π’-Ρ Π΅Π»ΠΏΠ΅ΡΠ½ΡΡ ΡΠΏΠΈΡΠΎΠΏΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΠΡΠ°
- 3. 4. 2. ΠΠ΅Π»ΠΎΠΊ ΠΡΡ
- 3. 4. 2. 1. Π‘ΡΡΡΠΊΡΡΡΠ°, ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° ΠΡΡ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis ΠΈ Π΅Π³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΈ
- 3. 4. 2. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° ΠΡΡ
- 3. 5. ΠΠ΅Π»Π΅Π·ΠΎΡΠ΅Π³ΡΠ»ΠΈΡΡΠ΅ΠΌΡΠ΅ Π±Π΅Π»ΠΊΠΈ
- 3. 5. 1. ΠΠ΅Π»ΠΊΠΈ Π’Π¬Ρ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ°
- 3. 5. 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° Π±Π΅Π»ΠΊΠ° Π’ΠͺΡΠ ΠΈ Π΅Π³ΠΎ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 5. 1. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° Π’Π¬ΡΠ
- 3. 5. 1. 3. Π‘ΡΡΡΠΊΡΡΡΠ° Π±Π΅Π»ΠΊΠ° Π’Π¬ΡΠ ΠΈ Π΅Π³ΠΎ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 5. 1. 4. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° Π’Π¬ΡΠ
- 3. 5. 1. ΠΠ΅Π»ΠΊΠΈ Π’Π¬Ρ ΡΡΠ°Π½ΡΡΠ΅ΡΡΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ°
- 3. 6. 1. Π‘ΡΡΡΠΊΡΡΡΠ° Π±Π΅Π»ΠΊΠ° NspA ΠΈ Π΅Π³ΠΎ ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Neisseria meningitidis
- 3. 6. 2. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π΅Π»ΠΊΠ° NspA
- 3. 7. ΠΠ΅Π»ΠΎΠΊ GNA
- 1. ΠΡΠ±ΠΎΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ Neisseria meningitidis. I. ΠΡΠ±ΠΎΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³ Π
- 1. 2. ΠΡΠ±ΠΎΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° ΠΡΠ°Π
- 1. 3. ΠΡΠ±ΠΎΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° NspA
- 2. Π‘ΠΈΠ½ΡΠ΅Π· ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ PorA, ΠΡΠ°Π ΠΈ NspA Neisseria meningitidis
- 3. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ , Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° PorA
- 4. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ , Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° ΠΡΠ°Π Neisseria meningitidis
- 5. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ , Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° NspA Neisseria meningitidis
Π‘ΠΈΠ½ΡΠ΅Π· ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π²Π½Π΅ΡΠ½Π΅ΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°-ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
ΠΠ°ΠΊΡΠ΅ΡΠΈΡ Neisseria meningitidis Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ ΡΡΠ΅Π΄ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ Π»ΡΠ΄Π΅ΠΉ, Π° Π² ΡΠ»ΡΡΠ°Π΅ Π²ΡΠ·Π΄ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ — ΠΊ ΡΠ°ΡΡΡΠΌ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡΠΌ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠΌ Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡΠΌΠΈ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠ΅Π· ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ: ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΡ ΠΎΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π΄ΠΎΡΡΠΈΠ³Π°Π΅Ρ 80%. ΠΠ»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΡ ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ Π΄ΠΎ 10%, ΠΎΠ΄Π½Π°ΠΊΠΎ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΈ Ρ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΠΊΠΈ Π·ΡΠ΅Π½ΠΈΡ Π²ΡΠ³ΠΎΠ΄Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠΉ Π±ΠΎΡΡΠ±Ρ Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΡ.
ΠΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π½ΠΎΠΉ ΠΊΠ°ΠΏΡΡΠ»Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ² Π΄Π΅Π»ΡΡ Π½Π° Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏ, ΠΏΡΠΈΡΠ΅ΠΌ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΡΠ²Π»ΡΡΡΡΡ ΡΡΠΈ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ — Π, Π ΠΈ Π‘. ΠΡΠΎΡΠΈΠ² ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°ΠΌΠΈ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏ, Π ΠΈ Π‘, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ Π΄ΠΎΠ²ΠΎΠ»ΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π²Π°ΠΊΡΠΈΠ½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ°ΠΏΡΡΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π°, ΠΊΠΎΡΠΎΡΡΠ΅, ΠΎΠ΄Π½Π°ΠΊΠΎ, ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠΌΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠ°ΠΌΠΈ (Π½Π΅ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π½Π° ΠΌΠ°Π»ΠΎΠ»Π΅ΡΠ½ΠΈΡ Π΄Π΅ΡΡΡ ). ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π²Π°ΠΊΡΠΈΠ½Π° ΠΏΡΠΎΡΠΈΠ² ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° ΠΎΠ΄Π½ΠΎΠΉ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π½Π΅ ΠΌΠΎΠΆΠ΅Ρ Π·Π°ΡΠΈΡΠ°ΡΡ ΠΎΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠΌ Π΄ΡΡΠ³ΠΎΠΉ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ.
ΠΠ»Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° Π²Π°ΠΊΡΠΈΠ½Ρ ΠΏΡΠΎΡΠΈΠ² Π±Π°ΠΊΡΠ΅ΡΠΈΠΈ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄ Π½Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ ΠΏΠΎ ΠΏΡΠΈΡΠΈΠ½Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π°, ΠΊΠΎΡΠΎΡΡΠΉ ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠ»ΡΠΊΠΎ Π»ΠΈΡΡ IgM-Π°Π½ΡΠΈΡΠ΅Π» Π² ΠΌΠ°Π»ΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π°Ρ , Π½Π΅ Π·Π°ΡΠΈΡΠ°ΡΡΠΈΡ ΠΎΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π°Π½ΡΠΈΠ³Π΅Π½Π½ΠΎΠ΅ ΡΡ ΠΎΠ΄ΡΡΠ²ΠΎ Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌΠΈ ΡΡΡΡΠΊΡΡΡΠ°ΠΌΠΈ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ Π΄ΡΡΠ³ΠΈΡ ΡΠΊΠ°Π½Π΅ΠΉ Π΄Π΅Π»Π°Π΅Ρ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄ Π ΠΎΠΏΠ°ΡΠ½ΡΠΌ Π΄Π»Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² Π²Π°ΠΊΡΠΈΠ½Π΅ ΠΈΠ·-Π·Π° Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ.
Π Π½Π°ΡΡΠΎΡΡΠΈΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ Π·Π°Π΄Π°ΡΠ° ΠΏΠΎΠΈΡΠΊΠ° Π½ΠΎΠ²ΡΡ , ΠΎΡΠ»ΠΈΡΠ½ΡΡ ΠΎΡ ΠΏΠΎΠ»ΠΈΡΠ°Ρ Π°ΡΠΈΠ΄Π°, ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ² N. meningitidis Ρ ΡΠ΅Π»ΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠΌ-ΠΌΡΠ½ΠΎΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°, Π·Π°ΡΠΈΡΠ°ΡΡΠ΅Π³ΠΎ Π² ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΠΎΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΠΎΠΉ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠΌ ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π.
ΠΠ°ΡΡΠΆΠ½Π°Ρ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π° Π±Π°ΠΊΡΠ΅ΡΠΈΠΈ //, meningitidis ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²ΠΎ Π±Π΅Π»ΠΊΠΎΠ², ΠΊ ΠΊΠΎΡΠΎΡΡΠΌ: Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΠΎΠ±ΡΠ°Π·ΡΡΡΡΡ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈ ΠΎΠΏΡΠΎΠ½ΠΈΠ·ΠΈΡΡΡΡΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π°. Π§Π΅ΠΌ Π±ΠΎΠ»ΡΡΠ΅ ΡΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΡΠ΅ΠΌ ΠΌΠ΅Π½Π΅Π΅ ΠΎΠ½ Π²ΠΎΡΠΏΡΠΈΠΈΠΌΡΠΈΠ² ΠΊ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΠ΄Π΅Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° Π΄Π»Ρ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²-ΠΈΠΎΠ³ΠΎ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΏΡΠΎΡΠ½ΠΎ ΡΡΠ²Π΅ΡΠ΄ΠΈΠ»Π°ΡΡ Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ 30 Π»Π΅Ρ.
ΠΠΎΠ²ΡΠΉ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ ΠΊ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΠΈΠ½ΡΠ΅Π·Π΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° ΠΈ Π² ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π½Π° ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π²Π°ΠΊΡΠΈΠ½ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. Π’Π°ΠΊΠΎΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΡ «Π½Π΅ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ» Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ, ΠΈΠ½Π΄ΡΡΠΈΡΡΡΡΠΈΠΌΠΈ ΡΡΡΠΎΠ³ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΈΠΌΠΌΡΠ½Π½ΡΠΉ ΠΎΡΠ²Π΅Ρ.
Π‘ ΡΠ΅Π»ΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ ΠΏΡΠΎΡΠΈΠ² ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° ΡΠ΅ΡΠΎΠ³ΡΡΠΏΠΏΡ Π Π² ΡΠ°ΠΌΠΊΠ°Ρ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»Π° ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Π° Π·Π°Π΄Π°ΡΠ° Π²ΡΠ±ΠΎΡΠ° ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ ΡΡΠ°ΡΡΠΊΠΎΠ² ΡΡΠ΅Ρ Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°: Π ΠΎΠ³Π, ΠΡΠ°Π ΠΈ NspA, Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½ΡΠ΅Π·Π° ΡΡΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ² ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ , Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΡΠ²ΠΎΠΉΡΡΠ².
Π²ΡΠ²ΠΎΠ΄Ρ.
1. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π°Π½Π°Π»ΠΈΠ·Π° ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ Π²ΡΠ±ΠΎΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π½Π°ΡΡΠΆΠ½ΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ° ΠΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ ΡΠΈΠ½ΡΠ΅Π· 14 ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π, Π ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° ΠΡΠ°Π ΠΈ 4 ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠ° NspA Π²Π½Π΅ΡΠ½Π΅ΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠ°.
2. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π ΠΎΠ³Π, ΠΡΠ°Π ΠΈ NspA ΡΠΏΠΎΡΠΎΠ±Π½ΠΎ ΠΏΡΠΎΡΠ²Π»ΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π΅Π½Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΠΌ Π²ΠΈΠ΄Π΅, Π±Π΅Π· ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΈΠΈ Ρ Π±Π΅Π»ΠΊΠΎΠ²ΡΠΌ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ.
3. ΠΡΡΠ²Π»Π΅Π½Ρ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ 178−199, 306−332 Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π, ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΠ΅ΡΡ Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½-Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΡΠΌΠΈ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ , Π·Π°ΡΠ°ΠΆΠ΅Π½Π½ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΡΠΌΠΈ N. meningitidis, ΠΈ ΡΠ²Π»ΡΡΡΠΈΠ΅ΡΡ Π-ΡΠΏΠΈΡΠΎΠΏΠ°ΠΌΠΈ.
4. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ 32−51, 118−143, 178−199, 273−292, 306−332, 346−363 Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π, 30−51, 64−83, 74−93, 109−130 Π±Π΅Π»ΠΊΠ° ΠΡΠ°Π ΠΈ 40−62 Π±Π΅Π»ΠΊΠ° NspA ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ ΠΈΠ½Π΄ΡΠΊΡΠΈΡ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΏΡΠΈ ΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠΌ ΡΡΠ°ΠΌΠΌΠ° Π44/76.
5. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ 32−51, 273−292, 306−332, 346−363 Π±Π΅Π»ΠΊΠ° Π ΠΎΠ³Π, 30−51 ΠΡΠ°Π ΠΈ 40−62 Π±Π΅Π»ΠΊΠ° NspA Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΈΠ½Π΄ΡΡΠΈΡΡΡΡ Π·Π°ΡΠΈΡΡ ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠΌ ΡΡΠ°ΠΌΠΌΠ° Π2394.
6. ΠΡΡΠ²Π»Π΅Π½Π½ΡΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π ΠΎΠ³Π, ΠΡΠ°Π ΠΈ NspA ΡΠ²Π»ΡΡΡΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ ΡΠ°Π·ΡΠ°Π±Π°ΡΡΠ²Π°Π΅ΠΌΠΎΠΉ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΌΠ΅Π½ΠΈΠ½Π³ΠΎΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ.
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