Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
Π Π°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ Π¦ΠΠ‘-2 Π² ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΠ°Π½ ΠΌΠΈΡΠ° ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡ ΠΏΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π²ΠΈΡΡΡ-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° (ΠΠ€Π), Π½Π΅ΠΏΡΡΠΌΠΎΠΉ ΠΈΠΌΠΌΡ-Π½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ (Π ΠΠ€) ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π²ΠΈΡΡΡΠ°, Π²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΈΠ»ΠΈ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΠΠ Π² ΡΠΊΠ°Π½ΡΡ ΠΈ ΠΎΡΠ³Π°Π½Π°Ρ ΠΏΠΎΡΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ in situ, ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- 1. ΠΠΠΠΠΠΠΠ
- 2. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 2. 1. ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 2. 2. ΠΠ΅ΡΠΎΠ΄Ρ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΈ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π¦ΠΠ‘
- 2. 3. ΠΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΠ΅ Π¦ΠΠ‘ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ½ΡΠ΅ Π±ΠΎΠ»Π΅Π·Π½ΠΈ)
- 2. 4. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ° ΠΈ ΠΌΠ΅ΡΡ Π±ΠΎΡΡΠ±Ρ Ρ Π¦ΠΠ‘
- Π‘ΠΠΠ‘Π’ΠΠΠΠΠ«Π ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ―
- 3. ΠΠΠ’ΠΠ ΠΠΠΠ« Π ΠΠΠ’ΠΠΠ«
- 4. Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π« ΠΠ‘Π‘ΠΠΠΠΠΠΠΠΠ
- 4. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ORF2 Π¦ΠΠ‘
- 4. 1. 1. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π³Π΅Π½Π½ΠΎΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ Π΄Π»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π½ΡΠΊΠ»Π΅ΠΎΠΊΠ°ΠΏΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ORF
- 4. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ORF2 Π¦ΠΠ‘
- 4. 1. 2. ΠΡΠΈΡΡΠΊΠ° ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠ½ΠΎΠ³ΠΎ Π½ΡΠΊΠ»Π΅ΠΎΠΊΠ°ΠΏΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ORF2 Π±Π΅Π»ΠΊΠ°
- 4. 2. ΠΡΠ±ΠΎΡ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°
- 4. 3. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π½Π΅ΠΏΡΡΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΠ€Π Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°
- 4. 3. 1. ΠΡΡΠ°Π±ΠΎΡΠΊΠ° ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΠ€Π
- 4. 3. 2. ΠΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΠ€Π ΠΏΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ± Π² ΠΎΠ΄Π½ΠΎΠΌ ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΠΈ
- 4. 3. 3. ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ
- 4. 4. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° («Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’»)
- 4. 4. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΉ Π΄Π»Ρ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ°
- 4. 4. 2. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° ΠΏΡΠΈ Ρ ΡΠ°Π½Π΅Π½ΠΈΠΈ
- 4. 4. 3. ΠΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°ΡΠΈΠΈ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΠΏΠΎ Π΅Π³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
- 4. 4. 4. ΠΠΎΠ½ΡΡΠΎΠ»Ρ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’»
- 4. 5. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» Π΄Π»Ρ ΡΠΏΠΈΠ·ΠΎΠΎΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π² ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
Π¦ΠΈΡΠΊΠΎΠ²ΠΈΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (Π¦ΠΠ‘-2) ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΌ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠΎΡΠΎΡΡΡ, Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π² ΠΠ°Π½Π°Π΄Π΅ Π² 1991 Π³ΠΎΠ΄Ρ, ΠΈ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Π½Π°Π·Π²Π°Π½Π½ΠΎΠΉ «ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΡΡΠ΅ΠΌ-Π½ΠΎΠ³ΠΎ ΠΌΡΠ»ΡΡΠΈΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠΎΡΠ΅Π½ΠΈΡ» (Π‘ΠΠΠ). ΠΠΎΠ»Π΅Π·Π½Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ², Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΡ ΠΏΠΎΡΠ΅ΡΡ Π²Π΅ΡΠ°, ΠΎΡΡΡΠ°Π²Π°Π½ΠΈΠ΅ Π² ΡΠΎΡΡΠ΅, ΠΎΠ΄ΡΡΠΊΡ, Π΄ΠΈΠ°ΡΠ΅Ρ, ΠΆΠ΅Π»ΡΡΡ Ρ ΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡ. Π Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π‘ΠΠΠ ΡΠ°ΡΠ΅ ΠΎΡΠΌΠ΅ΡΠ°ΡΡ Ρ ΠΏΠΎΡΠΎΡΡΡ 6−15 Π½Π΅Π΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°, Ρ ΠΊΠΎΡΠΎΡΡΡ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ ΠΎΡΡ ΠΎΠ΄, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΠΈΠΊ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΡΠΈΡ ΠΎΠ΄ΠΈΡΡΡ Π½Π° 10-ΡΠΈ Π½Π΅Π΄Π΅Π»ΡΠ½ΡΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ. Π£ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ Π²ΠΈΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ (ΠΌΠ°ΠΊΡΠΎΡΠ°Π³Π°Ρ , Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°Ρ , Π’ΠΈ ΠΠ»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ ), ΡΠ²Π»ΡΡΡΠΈΡ ΡΡ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ-ΠΌΠΈΡΠ΅Π½ΡΠΌΠΈ Π΄Π»Ρ Π¦ΠΠ‘-2 (ΠΡΠ»ΡΠ½ΠΊΠΈΠ½ Π.Π. ΠΈ Π΄Ρ., 2002; Clarck E.G., 1997; Allan G.M. et al., 1998; Mankertz A. et al., 2000; O’Connor B. et a. l, 2001 ΠΈ Π΄Ρ.). ΠΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠ΅ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π²ΠΈΡΡΡΠ° Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΈΡ ΠΊ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ. Π£ ΡΠ°ΠΊΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΡΠΎΠ·Π΄Π°ΡΡΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡ Π΄Π»Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π²ΡΠΎΡΠΈΡΠ½ΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ, Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΡΡ ΡΡΠ»ΠΎΠ²Π½ΠΎ-ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΠΌΠΈ ΠΌΠΈΠΊΡΠΎΠ±Π°ΠΌΠΈ (Segales J. et al., 2004). Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π¦ΠΠ‘-2 ΡΠΈΡΠΎΠΊΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΠΎ Π²ΡΠ΅Ρ ΡΡΡΠ°Π½Π°Ρ ΠΌΠΈΡΠ° ΠΈ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠ°ΠΊ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ (ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ ) ΠΏΠ°ΡΠΎΠ³Π΅Π½ΠΎΠ², Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΡΠ²ΠΈΠ½Π΅ΠΉ (ΠΡΠ»ΡΠ½ΠΊΠΈΠ½ Π.Π. ΠΈ Π΄Ρ., 2005; Halbur R.G., 1998).
Π¦ΠΠ‘-2 ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΠΠ-ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΉ Π²ΠΈΡΡΡ, ΠΎΡΠ½ΠΎΡΡΡΠΈΠΉΡΡ ΠΊ ΡΠΎΠ΄Ρ Circovirus ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Circoviridae, ΠΊ ΠΊΠΎΡΠΎΡΠΎΠΌΡ ΠΏΡΠΈΠ½Π°Π΄Π»Π΅ΠΆΠ°Ρ Π²ΠΈΡΡΡ Π°Π½Π΅ΠΌΠΈΠΈ ΡΡΠΏΠ»ΡΡ (ΡΠΈΠΏΠΎΠ²ΠΎΠΉ Π²ΠΈΡΡΡ), Π¦ΠΠ‘ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (Π¦ΠΠ‘-1), ΡΠ²Π»ΡΡΡΠΈΠΉΡΡ Π½Π΅ΡΠΈΡΠΎΠΏΠ°ΡΠΎ-Π³Π΅Π½Π½ΡΠΌ ΠΊΠΎΠ½ΡΠ°ΠΌΠΈΠ½Π°Π½ΡΠΎΠΌ ΠΏΠ΅ΡΠ΅Π²ΠΈΠ²Π°Π΅ΠΌΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ΅ΠΊ ΠΏΠΎΡΠΎΡΡΡΠ° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΠΏΠΎΠΏΡΠ³Π°Π΅Π² ΠΈ Π³ΠΎΠ»ΡΠ±Π΅ΠΉ. Π 1999 Π³. ΡΠΎΠΎΠ±ΡΠ°Π»ΠΎΡΡ ΠΎ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΎΡ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΈΠ· Π―ΠΏΠΎΠ½ΠΈΠΈ ΠΈ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ ΠΡΡΠΈΠΊΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (Hironori Π. et al., 1999; Mushahwar I.K. et al., 1999).
ΠΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΠ΅ΡΠ±, Π½Π°Π½ΠΎΡΠΈΠΌΡΠΉ ΡΠ²ΠΈΠ½ΠΎΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°ΠΌ Π±ΠΎΠ»Π΅Π·Π½ΡΠΌΠΈ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Ρ Π¦ΠΠ‘-2, ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΌ, ΡΡΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΏΠΎΡΠ΅ΡΡΠΌΠΈ ΠΎΡ Π½Π΅Π΄ΠΎΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΠΈ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΡΡ ΠΏΠΎΡΠΎΡΡΡ ΠΏΠΎΡΠ»Π΅ΠΎΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° (Sato Π. et al., 2001; Harding J.C., 2004). ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π² ΡΠ²ΡΠ·ΠΈ Ρ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΠΈΠΌ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠΌ Π² ΠΏΠ»Π°Π½Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π΄ΠΎΠ½ΠΎΡΠΎΠ², Π¦ΠΠ‘-2 ΠΌΠΎΠΆΠ΅Ρ ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ ΡΠ³ΡΠΎΠ·Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π»ΡΠ΄Π΅ΠΉ ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠ΅ ΡΠ΅ΡΠ΅Π· ΠΎΡΠ³Π°Π½, ΡΠΊΠ°Π½Ρ ΠΈΠ»ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ (Π‘Π°ΡΠΈΠ½Π° Π’.Π., 2003).
Π Π°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ Π¦ΠΠ‘-2 Π² ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΠ°Π½ ΠΌΠΈΡΠ° ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡ ΠΏΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π²ΠΈΡΡΡ-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° (ΠΠ€Π), Π½Π΅ΠΏΡΡΠΌΠΎΠΉ ΠΈΠΌΠΌΡ-Π½ΠΎΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ (Π ΠΠ€) ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π²ΠΈΡΡΡΠ°, Π²ΠΈΡΡΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΈΠ»ΠΈ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΠΠ Π² ΡΠΊΠ°Π½ΡΡ ΠΈ ΠΎΡΠ³Π°Π½Π°Ρ ΠΏΠΎΡΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ in situ, ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ (ΠΠ¦Π ), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎ-Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈ (Onuki A. et al., 1999; Choi Π‘. et al., 2000; Larochelle R. et al., 2000; Sibila M. et al., 2004; Racine S. et al., 2004 ΠΈ Π΄Ρ.). Π Π½Π°ΡΠ΅ΠΉ ΡΡΡΠ°Π½Π΅ Π² ΠΠΠ «ΠΠΠ ΠΠΠ ΠΠΠ» ΠΈ Π² Π€ΠΠ£ «ΠΠΠΠΠΠ» Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π¦ΠΠ‘-2 ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΠΠ¦Π (ΠΡΠΊΡΡΠΊΠΈΠ½ Π‘.Π. ΠΈ Π΄Ρ., 2005), ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΡΠΎΡ ΠΌΠ΅ΡΠΎΠ΄ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΄ΠΎΠ΅ΠΌΠΎΠΊ, ΡΡΠ΅Π±ΡΠ΅Ρ Π΄ΠΎΡΠΎΠ³ΠΎΡΡΠΎΡΡΠ΅ΠΉ Π°ΠΏΠΏΠ°ΡΠ°ΡΡΡΡ ΠΈ ΠΊΠ²Π°Π»ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»Π°. Π ΡΡΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ€Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ Π Π€.
ΠΠ·Π²Π΅ΡΡΠ½ΠΎ, ΡΡΠΎ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎ-ΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΡ ΡΠ΅ΡΡ ΡΠΈΡΡΠ΅ΠΌ Π΄Π»Ρ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ² ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ². Π Π³Π΅Π½ΠΎΠΌΠ΅ Π¦ΠΠ‘-2 ΠΏΡΠΈΡΡΡΡΡΠ²ΡΡΡ Π΄Π²Π΅ Π±ΠΎΠ»ΡΡΠΈΠ΅ ΠΎΡΠΊΡΡΡΡΠ΅ ΡΠ°ΠΌΠΊΠΈ ΡΡΠΈΡΡΠ²Π°Π½ΠΈΡ ORF1 ΠΈ ORF2, ΠΏΡΠΈ ΡΡΠΎΠΌ ORF2 ΠΊΠΎΠ΄ΠΈΡΡΠ΅Ρ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ Π²ΠΈΡΠΈΠΎΠ½Π° Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΎΠΉ ΠΎΠΊΠΎΠ»ΠΎ 30 ΠΊΠ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΈΠ½Π΄ΡΡΠΈΡΡΠ΅Ρ ΡΠΈΠ½ΡΠ΅Π· ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΌΠ°ΡΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΏΡΠΈ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ (Meehan Π.Π. et al., 1997; Truong Π‘. et al., 2001). Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π΄Π°Π½Π½ΡΠΉ Π±Π΅Π»ΠΎΠΊ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΌΡΠΌ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ΡΡΠΈΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ Π΄Π»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΠ€Π.
Π ΠΌΠΈΡΠ΅ ΡΠΆΠ΅ ΡΡΡΠ΅ΡΡΠ²ΡΡΡ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΡ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌ (Walker I.W. et al, 2000; Nawagitgul P. et al, 2002; Blanchard P. et al., 2003; Changming L. et al., 2004), ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΊ Π½Π°ΡΠ°Π»Ρ Π½Π°ΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π½ΠΈ ΠΎΠ΄Π½Π° ΠΈΠ· Π½ΠΈΡ Π½Π΅ ΠΎΠ±ΡΠ΅Π»Π° ΡΠΎΡΠΌΡ Π·Π°Π²Π΅ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ°, Π²ΡΠΏΡΡΠΊΠ°Π΅ΠΌΠΎΠ³ΠΎ Π½Π° ΡΠ΅Π³ΡΠ»ΡΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ°Ρ ΠΊΡΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ:
1. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ, ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΈ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°ΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΉ Π½ΡΠΊΠ»Π΅ΠΎΠΊΠ°ΠΏΡΠΈΠ΄Π½ΡΠΉ Π±Π΅Π»ΠΎΠΊ ORF2 ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°.
2. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΡ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ, ΡΡΠ΅ΡΠ° ΠΈ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π΅ΠΏΡΡΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΠ€Π Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ°Ρ ΠΊΡΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ .
3. ΠΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅Π½Π½ΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2 Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΠΎΠΉ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΡΡΠΈ.
4. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΠ€Π-Π½Π°Π±ΠΎΡΠ°. ΠΠ»Ρ ΡΡΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π½Π°Π±ΠΎΡΠ° ΠΏΡΠΈ Ρ ΡΠ°Π½Π΅Π½ΠΈΠΈ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ Π΅Π³ΠΎ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°ΡΠΈΡ ΠΈ ΠΈΠ½ΡΡΡΡΠΊΡΠΈΡ ΠΏΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ.
5. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠ΅ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° ΠΏΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2 Π² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΎΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ Π³ΡΡΠΏΠΏ.
6. ΠΡΠΎΠ²Π΅ΡΡΠΈ ΡΠΏΠΈΠ·ΠΎΠΎΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³ Π¦ΠΠ‘-2 Π² ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ Π Π€.
ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΡΠ°Π±ΠΎΡΡ.
Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΈ ΠΎΡΠΈΡΡΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ORF2 ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡ ΠΈΠΌΠΈ-ΡΠ΅ΡΠΊΠΈ ΠΎΡ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΌΠ΅ΡΠΎΠ΄ Π½Π΅ΠΏΡΡΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΠ€Π Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ. ΠΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΠ€Π ΠΏΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ, Π²Π·ΡΡΡΡ Π² ΠΎΠ΄Π½ΠΎΠΌ ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΠΈ. Π ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠ€Π ΠΈ Π ΠΠ€.
ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°ΡΠΈΡ ΠΈ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΠ€Π-Π½Π°Π±ΠΎΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Ρ ΡΠ°Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° ΠΈ Π΅Π³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ , Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π½Π° Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2.
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ.
ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ Π² Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ Π ΠΎΡΡΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΠ€Π-Π½Π°Π±ΠΎΡ «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» ΠΊΠΎΡΠΎΡΡΠΉ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΌΠ°ΡΡΠΎΠ²ΡΡ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ΠΎΠ²ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ²ΠΈΠ½ΠΎΠΏΠΎΠ³ΠΎΠ»ΠΎΠ²ΡΡ Π΄Π»Ρ ΡΠΏΠΈΠ·ΠΎΠΎΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π¦ΠΠ‘-2. ΠΠ° ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎ-ΡΠ΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°ΡΠΈΡ, ΡΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½Π°Ρ Π² ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΏΠΎΡΡΠ΄ΠΊΠ΅ (Π’Π£ 9388−010−42 418 073−04).
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠΈ Π¦ΠΠ‘-2 Π² ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ Π Π€. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ, Π²ΡΠ½ΠΎΡΠΈΠΌΡΠ΅ Π½Π° Π·Π°ΡΠΈΡΡ.
ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π²ΡΠ½Π΅ΡΡΠΈ Π½Π° Π·Π°ΡΠΈΡΡ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ:
β’ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠΎ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ORF2 ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π½Π° Π΅Π΅ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2;
β’ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΉ ΠΠ€Π Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ ;
β’ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΏΠΈΠ·ΠΎΠΎΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π¦ΠΠ‘-2 Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ Π½Π° ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ.
ΠΠΏΡΠΎΠ±Π°ΡΠΈΡ ΡΠ°Π±ΠΎΡΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π΄ΠΎΠ»ΠΎΠΆΠ΅Π½Ρ Π½Π° 1-ΠΌ ΠΡΠ΅ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΌ ΡΠΎΠ²Π΅ΡΠ°Π½ΠΈΠΈ Π΄ΠΈΡΠ΅ΠΊΡΠΎΡΠΎΠ² Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΡΡ Π»Π°Π±ΠΎΡΠ°ΡΠΎ-I ΡΠΈΠΉ ΡΡΠ±ΡΠ΅ΠΊΡΠΎΠ² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ (Π³.ΠΡΡΠ½ΡΠΊ, 2004) — Π½Π°ΡΡΠ½ΠΎ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ²Π΅ΡΠ°Π½ΠΈΡΡ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² ΠΠΠ «ΠΠΠ ΠΠΠ ΠΠΠ» (Π³. ΠΠΎΡΠΊΠ²Π°, 2003 — 2005 Π³Π³.) — ΠΌΠ΅ΠΆΠ»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΌ ΡΠΎΠ²Π΅ΡΠ°Π½ΠΈΠΈ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² ΠΠ½ΡΡΠΈΡΡΡΠ° Π²ΠΈΡΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΌ. Π. Π. ΠΠ²Π°Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ Π ΠΠΠ (Π³. ΠΠΎΡΠΊΠ²Π°, 2006 Π³.).
ΠΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ. ΠΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½ΠΎ ΡΡΠΈ Π½Π°ΡΡΠ½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ ΠΈ ΠΎΠ΄Π½Π° ΠΏΡΠΈΠ½ΡΡΠ° Π² ΠΏΠ΅ΡΠ°ΡΡ.
ΠΠ±ΡΠ΅ΠΌ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ. ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Π° Π½Π° 118 ΡΡΡ. ΠΌΠ°ΡΠΈΠ½ΠΎΠΏΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΊΡΡΠ° ΠΈ ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· Π²Π²Π΅Π΄Π΅Π½ΠΈΡ, ΠΎΠ±Π·ΠΎΡΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ², Π²ΡΠ²ΠΎΠ΄ΠΎΠ², ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΈΠΉ, Ρ ΡΠΏΠΈΡΠΊΠ° ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΈΠ».
6. Π²ΡΠ²ΠΎΠ΄Ρ.
1. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ORF2 ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π³Π΅Π½Ρ Π½ΡΠΊΠ»Π΅ΠΎΠΊΠ°ΠΏΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° Π¦ΠΠ‘-2 ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ Π² ΡΡΠΊΠ°ΡΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ Π²ΡΡ ΠΎΠ΄ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° ΡΠΎΡΡΠ°Π²ΠΈΠ» 0,05−0,11% ΠΎΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π±ΠΈΠΎΠΌΠ°ΡΡΡ.
2. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΎΡΠΈΡΠ΅Π½Π½ΡΠΉ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ°ΡΡΠΈΠ½Π½ΠΎΠΉ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠ΅ΠΉ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ ORP2 ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌΠΈ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° Π² ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΠ΅.
3. Π‘ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° ORP2 ΠΈ ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Ρ — ΡΠ΅ΠΏΡΠΌ IgG ΡΠ²ΠΈΠ½ΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΌΠ΅ΡΠΎΠ΄ Π½Π΅ΠΏΡΡΠΌΠΎΠ³ΠΎ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΠ€Π, ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΡΠΉ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2. ΠΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π½Π΅ΠΏΡΡΠΌΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ»ΡΠΎ-ΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 96,2%, ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ — 95,4%. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΠ€Π ΠΈ Π ΠΠ€ ΡΠΎΠ²ΠΏΠ°Π΄Π°Π»ΠΈ Π² 95,7% ΡΠ»ΡΡΠ°Π΅Π², ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΎΡΡΠ°Π²ΠΈΠ» 0,88, Π < 0,05.
4. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» ΠΈ ΠΠ½ΡΡΡΡΠΊΡΠΈΡ ΠΏΠΎ Π΅Π³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΊΠ°Π·Π°Π½Π½ΡΠΉ Π½Π°Π±ΠΎΡ ΠΏΡΠΈΠ³ΠΎΠ΄Π΅Π½ Π΄Π»Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π³ΠΎΠ΄Π° ΠΏΡΠΈ Ρ ΡΠ°Π½Π΅Π½ΠΈΠΈ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ 4−8Β°Π‘.
5. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠ³ΠΎ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° * «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» ΠΏΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΌΠ°ΡΡΠΎΠ²ΡΡ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ΠΎΠ²ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΊΡΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π¦ΠΠ‘-2 Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ . ΠΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π°ΠΌΠΈ ΡΠΊΠ°Π·Π°Π½Π½ΠΎΠ³ΠΎ Π½Π°Π±ΠΎΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡ-Π½ΠΎΡΡΡ, Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² (Π³ = 0,9) ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ΅ΡΠ°.
6. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π² 20 ΡΠ²ΠΈΠ½ΠΎΠ²ΠΎΠ΄ΡΠ΅ΡΠΊΠΈΡ Ρ ΠΎΠ·ΡΠΉΡΡΠ²Π°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠ΅Π³ΠΈΠΎΠ½ΠΎΠ² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’», ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ Π¦ΠΠ‘-2 Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΡΠ²ΠΈΠ½Π΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ Π³ΡΡΠΏΠΏ. ΠΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ 26% ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΏΡΠΎΠ± ΡΠΎΠ΄Π΅ΡΠΆΠ°Π»ΠΈ ΡΠ°ΠΊΠΆΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π²ΠΈΡΡΡΡ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎ-ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΡΠ²ΠΈΠ½Π΅ΠΉ.
7. ΠΠ ΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠ ΠΠ ΠΠΠΠΠΠΠΠΠ―.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠ€Π-Π½Π°Π±ΠΎΡΠ° Π²ΠΎΡΠ»ΠΈ Π² ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠ΅ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΡ:
— Π’Π΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ (Π’Π£) № 9388−010−42 418 073−04 «ΠΠ°Π±ΠΎΡ ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (Π¦ΠΠ‘-2) ΠΈΠΌ-ΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’» «, ΡΠΎΠ³Π»Π°ΡΠΎΠ²Π°Π½Ρ Ρ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±ΠΎΠΉ ΠΏΠΎ Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΠΎΠΌΡ ΠΈ ΡΠΈΡΠΎΡΠ°Π½ΠΈΡΠ°ΡΠ½ΠΎΠΌΡ Π½Π°Π΄Π·ΠΎΡΡ Π Π€ 27.07.2005;
— ΠΠ½ΡΡΡΡΠΊΡΠΈΡ ΠΏΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½Π°Π±ΠΎΡΠ° ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΡΠΊΠΎΠ²ΠΈΡΡΡΡ ΡΠ²ΠΈΠ½Π΅ΠΉ Π²ΡΠΎΡΠΎΠ³ΠΎ ΡΠΈΠΏΠ° (Π¦ΠΠ‘-2) ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ «Π¦ΠΠ ΠΠ-Π‘ΠΠ ΠΠ’ΠΠ‘Π’», ΡΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±ΠΎΠΉ ΠΏΠΎ Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠ½ΠΎΠΌΡ ΠΈ ΡΠΈΡΠΎΡΠ°Π½ΠΈΡΠ°ΡΠ½ΠΎΠΌΡ Π½Π°Π΄Π·ΠΎΡΡ Π Π€ 27.07.2005.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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